ACR Meeting Abstracts

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Abstracts tagged "Behçet’s Syndrome"

  • Abstract Number: 1562 • ACR Convergence 2023

    Behcet’s Disease Coagulopathy in a Racially Diverse Patient Population

    Sundus Mian1, Talia Meisel2, Hussain Md1, Xianhong Xie3, Tamara Tanner1, Anand Kumthekar4 and Bibi Ayesha4, 1Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, 2Montefiore Medical Center, Bronx, NY, 3Albert Einstein College of Medicine, Bronx, NY, 4Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY

    Background/Purpose: Behcet's disease (BD) is a vasculitis with both thrombotic and bleeding complications which can make management challenging. Thrombosis is due to direct vascular inflammation,…
  • Abstract Number: 0258 • ACR Convergence 2023

    Understanding Monogenic Behçet’s Disease Pathophysiology: Impact of Pathogenic Variant L227X Associated with Autoinflammatory A20 Haploinsufficiency on Cellular Survival and Proliferation

    Patricia Aires1, Daniela Pioto1, Maria Teresa TErreri2 and Sandro Perazzio3, 1Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil, 2UNIFESP, São Paulo, Brazil, 3Universidade de Sao Paulo (Unifesp); Universidade de São Paulo (USP); Fleury Laboratories, São Paulo, Brazil

    Background/Purpose: A20, encoded by TNFAIP3, plays a critical role in NF-κB pathway regulation. A20 haploinsufficiency is a monogenic disorder form of Behçet's disease with a…
  • Abstract Number: 1563 • ACR Convergence 2023

    Methotrexate: A Safe and Effective Therapeutic Alternative in Behçet´s Disease

    Miriam Retuerto-Guerrero1, Elvira Díez Álvarez1, Javier Narvaez2, Rosa Fornons Servent3, Carlos Moreno Vilchez3, Jenaro Graña Gil4, Uxía Couto Lareo5, Carmen San José-Méndez4 and Clara Moriano Morales1, 1Rheumatology, Hospital Universitario de León, León, Spain, 2Hospital Universitario de Bellvitge, Barcelona, Spain, 3Dermatology, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Spain, 4Rheumatology, Hospital A Coruña, A Coruña, Spain, 5Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain

    Background/Purpose: Behçet's disease (BD) is characterized by great clinical heterogeneity. The therapeutic strategy for BD could be tailored to the specific needs of the patient,…
  • Abstract Number: 0692 • ACR Convergence 2023

    Behçet’s Disease-Associated TCR in the Eye Points to HLA Class I-Restricted Autoimmunity

    Johannes Nowatzky1, Ziyan Lin2, Yesim Ozguler3, Alireza Khodadadi-Jamayran2, Didar Ucar4, Aristotelis Tsirigos5, Gulen Hatemi6 and Olivier Manches7, 1NYU Grossman School of Medicine, Department of Medicine, Department of Pathology, Division of Rheumatology, NYU Behçet's Disease Program, NYU Ocular Rheumatology Program, New York, NY, 2NYU Grossman School of Medicine, Applied Bioinformatics Laboratories, New York, NY, 3NYU Grossman School of Medicine, Department of Medicine, Division of Rheumatology and Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, New York, NY, 4Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Ophthalmology, Istanbul, Turkey, 5NYU Grossman School of Medicine, Department of Pathology, Department of Medicine, Institute for Computational Medicine, New York, NY, 6Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 7EFS, Recherche et Développement, Department of Pulmonology and Physiology, CHU Grenoble-Alpes, Université Grenoble-Alpes, INSERM U1209, CNRS UMR, Institute for Advanced Biosciences, Grenoble, France

    Background/Purpose: Behçet's disease (BD) is an HLA class I-associated disorder, given its strong link to HLA-B*51. However, evidence of HLA class I restriction is lacking,…
  • Abstract Number: 1564 • ACR Convergence 2023

    Common Femoral Vein Wall Thickness Measurement as a Diagnostic Test in Suspected Behçet’s Disease

    fatma Alibaz-Öner1, Rabia Ergelen2, Seda Kutluğ Ağaçkıran3, Fatma Temiz4, Tulin Ergun5 and Haner Direskeneli6, 1Marmara University, School of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Marmara University, School of Medicine, Department of Radiology, Istanbul, Turkey, 3Marmara University, School of Medicine, Division of Rheumatology, Istanbul, Turkey, 4Marmara University, School of Medicine, Department of Internal Medicine, Istanbul, Turkey, 5Marmara University, School of Medicine, Department of Dermatology, Istanbul, Turkey, 6Division of Rheumatology, Medical School, Marmara University, Istanbul, Turkey

    Background/Purpose: The diagnosis of Behçet's disease (BD) is mainly based on multi-systemic clinical manifestations after ruling out other potential causes. There is no specific diagnostic…
  • Abstract Number: 0701 • ACR Convergence 2023

    Incidence of Neurobehçet Disease in Northern Spain 1999-2019. a Population-based Study

    Fabricio Benavides1, Alba Herrero-Morant2, Jose Luis Martin-Varillas3, Carmen Alvarez Reguera1, Lara Sanchez-Bilbao4, David Martinez-Lopez5, Raul Fernandez1, Ivan Ferraz Amaro6, Jose Luis Hernandez1 and Ricardo Blanco7, 1Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, Ontinyent, Spain, 3Hospital de Laredo, Laredo, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Spain, 5Hospital de Sierrallana, Santander, Spain, 6Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 7Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Behçet’s Disease (BD) incidence varies widely worldwide. Neurobehcet’s disease (NBD) is one of the most severe manifestations of BD. Data on NBD incidence is…
  • Abstract Number: 2517 • ACR Convergence 2023

    The Relationship Between the NETosis Findings and Disease Activity in Behcet Disease

    Erdem Bektas1, Rabia Deniz2, Zeliha Emrence3, Sema Sırma Ekmekci3, Neslihan Abacı3, Shirkhan Amikishiyev4, Yasemin Yalçınkaya4, Bahar Artim Esen4, Murat Inanç5 and Ahmet Gul6, 1Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey, 2University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Department of Rheumatology, Istanbul, Turkey, 3Istanbul University, Aziz Sancar Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey, 4Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 5Istanbul University, Istanbul, Turkey, 6Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Background/Purpose: Behcet disease (BD) is a multisystemic inflammatory disease of unknown etiology. BD has been classified among the neutrophilic dermatosis, and neutrophil extracellular traps (NETs)…
  • Abstract Number: 0801 • ACR Convergence 2023

    LncRNA PIGL-217 Regulates Th17 Differentiation by Targeting miR-5008-5p and Suppressing FoxO1 in Behçet’s Disease

    Zhimian Wang, Xin Yu, Hua Chen and Wenjie Zheng, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: Dysregulated Th17 cells are implicated in Behçet's disease (BD). However, the underlying mechanism remains unclear. Here we aim to elucidate the mechanism of forkhead…
  • Abstract Number: 2519 • ACR Convergence 2023

    A Phase II Clinical Study to Investigate the Efficacy and Safety of Hemay005 Tablets in Patients with Active Behçet`sDisease

    Charles Jones1, Zhanguo Li2, Zhuoli Zhang3, Jian Wu4, Guixiu Shi5, Wenjie Zheng6, Jianping Tang7, Xiaobing Wang8, Lie Dai9, Lin Chen10, Yasong Li11, Ling Wu12, Yongfu Wang13, Shengyun Liu14, Yao Ke15, Jin Lin16, Zhenchun Zhang17, Jiankang Hu18, Wantai Dang19, Songlou Yin20, Xin Tang21, Mingfei Zhu22, Jinfeng Lin22, Richard Jones22, Weiguo Wan23 and xianjun Hu22, 1Hemay Pharmaceuticals, Tianjin, China, 2Peking University Health Science Center, Department of Rheumatology and Immunology, People's Hospital, Beijing, China, 3Peking University First Hospital, Rheumatology and Immunology Department, Beijing, China, 4Suzhou University Affiliated First Hospital, Suzhou, China, 5the First Affiliated Hospital of Xiamen University, Xiamen, China, 6Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, 7Shanghai Tongji Hospital, Shanghai, China, 8The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, 9Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 10Jilin Provincial People's Hospital, Changchun, China, 1111Zhejiang Provincial People's Hospital, Hangzhou, China, 12University of Hong Kong Shenzhen Hospital, Shenzhen, China, 13The First Affiliated Hospital of Baotou Medical College, Baotou, China, 14The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 15Jiangsu Provincial People's Hospital, Nanjing, China, 16The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 17Linyi People's Hospital, Linyi, China, 18Pingxiang People’s Hospital, PingXiang, China, 19The First Affiliated Hospital of Chengdu Medical College, Chengdu, China, 20Xuzhou Medical University Affiliated Hospital, Xuzhou, China, 21Bestudy (Shanghai) Medical Technology Co., Ltd, Shanghai, China, 22Clinical Department, Tianjin Hemay Pharmaceutical Co., Ltd., Tianjin, China, 23Huashan Hospital Affiliated to Fudan University, Shanghai, China

    Background/Purpose: Behçet's disease (BD) is a chronic and recurrent vascular inflammatory disease with major manifestations including oral ulcers, genital ulcers, skin damage and ophthalmitis, and…
  • Abstract Number: 1126 • ACR Convergence 2023

    Identification of Clinical Phenotypes in Behçet’s Disease Using a Cluster Analysis

    Ana Serrano-Combarro1, Jose Luis Martin-Varillas2, Raul Fernandez-Ramon3, Lara Sanchez-Bilbao4, Carmen Alvarez Reguera3, ELENA Aurrecoechea5 and Ricardo Blanco6, 1Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain, 2Hospital de Laredo, Laredo, Spain, 3Hospital Universitario Marqués de Valdecilla, Santander, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Spain, 5HOSPITAL SIERRALLANA, Cantabria, Spain, 6Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

    Background/Purpose: Behcet's disease (BD) is a variable-vessel vasculitis with a high variability of clinical manifestations. The objective of our study was to identify clinical phenotypes…
  • Abstract Number: 1228 • ACR Convergence 2023

    Validation of the PEDiatric Behçet’s Disease Classification Criteria (PEDBD): An International Consensus-based Approach

    Caterina Matucci-Cerinic1, helene Palluy2, Sulaiman Al-Mayouf3, Paul Brogan4, Luca Cantarini5, Ahmet Gul6, Ozgur Kasapcopur7, Jasmin B. Kuemmerle-Deschner8, Seza Ozen9, david saadoun10, Farhad Shahram11, Francesca Bovis12, Eugenia mosci13, Nicolino Ruperto14, Marco Gattorno15 and Isabelle Kone-Paut16, 1DINOGMI, University of Genoa; IRCCS Istituto Giannina Gaslini, UOC Rheumatology and autoinflammatory diseases, Genova, Italy, 2Pediatric rheumatology and CEREMAIA, Bicêtre hospital, APHP, University of Paris Saclay, Paris, France, 3King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia, 4UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 5Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, 6Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 7Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, 8med.uni-tuebingen, Tübingen, Germany, 9Hacettepe University Medical Faculty, Ankara, Turkey, 10Sorbonne Universités, Department of Internal Medicine and Clinical Immunology, Centre de Référence des Maladies Auto-Inflammatoires et de l’Amylose inflammatoire, F-75013, Paris, France; AP-HP, Groupe Hospitalier Pitié-Salpêtrière., Neuilly sur Seine, France, 11Rheumatology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran, 12Dept of Health Sciences (DISSAL), University of Genoa, Genova, Italy, 13UOC Servizio di Sperimentazioni Cliniche Pediatriche, PRINTO, IRCCS Istituto Giannina Gaslini, Genova, Italy, 14IRCCS Istituto Giannina Gaslini, UOSID Centro Trial, Genova, Italy, 15UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy, 16Department of Pediatric Rheumatology, Reference Centre for Autoinflammatory Disorders CEREMAIA, Bicêtre Hospital, APHP, University of Paris Saclay, Paris, France

    Background/Purpose: Behçet's disease (BD) is an autoinflammatory disease characterized by a variable vessel vasculitis. In the past, several criteria have been created for adult BD…
  • Abstract Number: 1248 • ACR Convergence 2023

    Thrombotic Manifestations in Pediatric Behçet Disease Patients: A Multicentre Comparative Study from EUROFEVER Registry

    Maria Vincenza Mastrolia1, Caterina Matucci-Cerinic2, Seza Ozen3, Ozgur Kasapcopur4, Carla Gaggiano5, Isabelle Kone-Paut6, Luca Cantarini5, Perrine Dusser7, Ümmüşen Kaya-Akça8, Mehmet Yildiz9, Juergen Brunner10, Giovanni Filocamo11, Romina Gallizzi12, Antonella Insalaco13, Serena Pastore14, Donato Rigante15, Judith Sanchez-Manubens16, Elena Tsitsami17, Marco Gattorno18 and Gabriele Simonini19, 1NEUROFARBA Department, University of Florence, Florence, Italy, 2DINOGMI, University of Genoa; IRCCS Istituto Giannina Gaslini, UOC Rheumatology and autoinflammatory diseases, Genova, Italy, 3Hacettepe University Medical Faculty, Ankara, Turkey, 4Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, 5Department of Medical Sciences, Surgery and Neurosciences, Rheumatology Unit, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Siena, Italy, 6Department of Pediatric Rheumatology, Reference Centre for Autoinflammatory Disorders CEREMAIA, Bicêtre Hospital, APHP, University of Paris Saclay, Paris, France, 7Department of Pediatric Rheumatology, Reference Centre for Autoinflammatory Disorders CEREMAI, Bicêtre Hospital, University of Paris SUD, Paris, France, 8Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey, 9Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Instanbul, Turkey, 10Medical University Innsbruck; Department of Pediatrics, Pediatric Rheumatology, Innsbruck, Austria, 11Pediatric Immunorheumatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, MIlan, Italy, 12Department of Medical of Health Sciences, Magna Graecia University, Catanzaro, Italy, 13Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, 14Institute for Maternal and Child Health, RCCS “Burlo Garofolo", Trieste, Italy, 15Department of Life Sciences and Public Health, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy, 16Pediatric Rheumatology, Section Pediatric Service, Parc Taulí Sabadell University Hospital, Institute for Research and Innovation I3PT, Sant Joan de Deu Hospital, Autonomous University of Barcelona, Barcelona, Spain, 17Pediatric Rheumatology Unit, 1st Department of Pediatrics, Children's Hospital "Aghia Sophia", University of Athens, Athens, Greece, 18UOC Reumatologia e Malattie Autoinfiammatorie, Genoa, Italy, 19Rheumatology Unit, ERN ReConnet Center, Meyer Children's Hospital IRCCS, Florence Italy. NeuroFARBA Department, University of Florence, Florence, Italy

    Background/Purpose: Arterial and venous thrombosis occurs in 6.6 to 38.4% of pediatric Behçet disease (BD) and cerebral sinus is one of the most involved districts.…
  • Abstract Number: 1554 • ACR Convergence 2023

    Therapeutic Approaches and Predictive Factors of Relapse in Severe Ocular Involvement in Behçet’s Disease: A Multicentre Retrospective Study

    Audrey Hermant1, Yann Nguyen2, Fleur Cohen3, Antoine Baudet4, Alban DEROUX5, Vincent Poindron6, Cécile-Audrey Durel7, Nicolas Girszyn8, Noémie Le Gouellec9, Benedicte Rouviere10, Helder Gil11, Francois Maurier12, Nicolas Noel13, Loic Raffray14, Hubert De Boysson15, Benoit Faucher16, Bertrand Godeau17, Pierre Lozach18, Claude Bachmeyer19, Alice Berezne4, Gilles Blaison20, Brice Castel21, Guillaume Gondran22, Matthieu Groh23, Stéphane Giorgiutti24, Jeremy Keraen25, Julie Magnant26, Sebastien Monnier27, Philippe Blanche28, Dominique Monnet29, Antoine Brezin29 and Benjamin Terrier30, 1Hopital Cochin, Paris, France, 2Department of Internal Medicine, Hôpital Beaujon, AP-HP, Clichy, France., Montmorency, France, 3Sorbonne Université, Paris, France, 4CH Annecy, Annecy, France, 5CHU de Grenoble, Grenoble, France, 6Strasbourg, Strasbourg, France, 7CHU Lyon, Lyon, France, 8Rouen, Rouen, France, 9CH Valenciennes, Valenciennes, France, 10CHU Brest, Brest, France, 11CHU Besancon, Besançon, France, 12CH Metz, Metz, France, 13CHU Bicetre, Le Kremlin-Bicêtre, France, 14CHU la Réunion, La Réunion, France, 15CHU Caen, Caen, France, 16CHU Marseille, Marseille, France, 17CHU Henri Mondor, Créteil, France, 18CH Le Mans, Le Mans, France, 19CHU Tenon, Paris, France, 20Hôpital Louis PASTEUR, Colmar, France, 21CH Tarbes, Tarbes, France, 22CHU Limoges, Limoges, France, 23National Referral Center for Hypereosinophilic Syndrome (CEREO), Hôpital Foch, Suresnes, France, 24CHRU Strasbourg, Strasbourg, France, 25CH Quimper, Quimper, France, 26CHU Tours, Tours, France, 27CH Versailles, Versailles, France, 28Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 29CHU Cochin, Paris, France, 30Department of Internal Medicine, Hôpital Cochin, AP-HP, Paris, France

    Background/Purpose: The management of severe ocular involvement in Behçet's disease (BD) is an important issue with major functional implications due to the risk of blindness.…
  • Abstract Number: 1555 • ACR Convergence 2023

    Axial Spondyloarthritis in Patients with Gastrointestinal Involvement of Behçet Syndrome

    Musab Ozturk1, Sinem Nihal Esatoglu2, Ibrahim Hatemi3, Aykut Ferhat Celik3, Osman Aykan Kargin4, Ahmet Oz4, Erkan Yilmaz5, Didar Ucar6, Melike Melikoglu2, Hasan Yazici7, Ibrahim Adaletli4 and Gulen Hatemi2, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Istanbul, Turkey, 2Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 3Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey, 4Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Radiology, Istanbul, Turkey, 5Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Tissue Typing Laboratory, Istanbul, Turkey, 6Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Ophthalmology, Istanbul, Turkey, 7Academic Hospital, Istanbul, Turkey

    Background/Purpose: Controlled studies have shown that radiographic sacroiliitis was not increased in Behçet syndrome (BS), compared to other inflammatory diseases. However, gastrointestinal involvement of Behçet…
  • Abstract Number: 1556 • ACR Convergence 2023

    Abdominal Surgical Interventions Among Patients with Gastrointestinal Involvement of Behçet Syndrome

    Sinem Nihal Esatoglu1, Sabriye Guner1, Sevim Guler2, Gulen Hatemi1, Nuray Kepil3, Yusuf Ziya Erzin4, Aykut Ferhat Celik4 and Ibrahim Hatemi4, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Istanbul, Turkey, 3Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Pathology, Istanbul, Turkey, 4Istanbul University-Cerrahpasa, Cerrahpasa Medical School, Department of Internal Medicine, Division of Gastroenterology, Istanbul, Turkey

    Background/Purpose: Gastrointestinal involvement of Behçet's syndrome (GIBS) may require surgery in up to one third of the patients. We aimed to investigate the clinical characteristics,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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