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Abstracts tagged "basic calcium phosphate"

  • Abstract Number: 847 • ACR/ARHP Annual Meeting 2018

    Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of Calcium/Calmodulin Kinase 2

    Jing Rong1, Bregina Pool2, Mark Zhu3, Jacob Munro4, Geraldine M. McCarthy5, Jillian Cornish2, Nicola Dalbeth1 and Raewyn Poulsen3, 1University of Auckland, Auckland, New Zealand, 2Department of Medicine, University of Auckland, Auckland, New Zealand, 3Medicine, University of Auckland, Auckland, New Zealand, 4Orthopaedics, Auckland City Hospital, Auckland, New Zealand, 5Mater Misericordiae University Hospital, Dublin, Ireland

    Background/Purpose: Basic calcium phosphate crystals (BCP) are frequently found in osteoarthritic joints. Whether BCP crystal deposition is a cause or consequence of osteoarthritis (OA) pathology…
  • Abstract Number: 214 • ACR/ARHP Annual Meeting 2015

    Basic Calcium Phosphate Crystal Interactions with Tenocytes: An in Vitro Model of Calcific Tendinitis

    Nicola Dalbeth1,2, Bregina Pool1, Ashika Chhana3, Karen E. Callon2, Dorit Naot3, Ryan Gao2, Brendan Coleman4, Jillian Cornish1 and Geraldine M. McCarthy5, 1Department of Medicine, University of Auckland, Auckland, New Zealand, 2University of Auckland, Auckland, New Zealand, 3Medicine, University of Auckland, Auckland, New Zealand, 4Orthopedic Surgery, Middlemore Hospital, Auckland, New Zealand, 5University College Dublin, Dublin, Ireland

    Background/Purpose: Basic calcium phosphate (BCP) crystals frequently deposit in tendons and may cause an acute inflammatory syndrome of calcific tendinitis. Tenocytes are the stromal cells…
  • Abstract Number: 1050 • ACR/ARHP Annual Meeting 2014

    A Role for Purinergic Receptor Signalling in Basic Calcium Phosphate Crystal-Induced Inflammation

    Clare C. Cunningham1, Emma M. Corr1, Geraldine M. McCarthy2 and Aisling Dunne1, 1School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, 2Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland

    Background/Purpose: Basic calcium phosphate (BCP) crystals are uniquely associated with osteoarthritis (OA). They are found in the majority of affected joints and closely correlate with…
  • Abstract Number: 50 • ACR/ARHP Annual Meeting 2013

    Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice

    Jessica Bertrand1, Tabea Kräft2, Yvonne Nitschke3, Thelonius Hawellek4, Jan Hubert4, Lars Godmann5 and Thomas Pap5, 1Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, 2Inst, University Hospital Münster, Muenster, Germany, 3University Hospital Münster, Muenster, Germany, 4University Hospital Hamburg, Hamburg, Germany, 5Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany

    Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…

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