Abstracts tagged "basic calcium phosphate"

Abstract Number: 847 • 2018 ACR/ARHP Annual Meeting
Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of Calcium/Calmodulin Kinase 2
Jing Rong¹, Bregina Pool², Mark Zhu³, Jacob Munro⁴, Geraldine M. McCarthy⁵, Jillian Cornish², Nicola Dalbeth¹ and Raewyn Poulsen³, ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Medicine, University of Auckland, Auckland, New Zealand, ⁴Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁵Mater Misericordiae University Hospital, Dublin, Ireland
Background/Purpose: Basic calcium phosphate crystals (BCP) are frequently found in osteoarthritic joints. Whether BCP crystal deposition is a cause or consequence of osteoarthritis (OA) pathology…
Abstract Number: 214 • 2015 ACR/ARHP Annual Meeting
Basic Calcium Phosphate Crystal Interactions with Tenocytes: An in Vitro Model of Calcific Tendinitis
Nicola Dalbeth^1,2, Bregina Pool¹, Ashika Chhana³, Karen E. Callon², Dorit Naot³, Ryan Gao², Brendan Coleman⁴, Jillian Cornish¹ and Geraldine M. McCarthy⁵, ¹Department of Medicine, University of Auckland, Auckland, New Zealand, ²University of Auckland, Auckland, New Zealand, ³Medicine, University of Auckland, Auckland, New Zealand, ⁴Orthopedic Surgery, Middlemore Hospital, Auckland, New Zealand, ⁵University College Dublin, Dublin, Ireland
Background/Purpose: Basic calcium phosphate (BCP) crystals frequently deposit in tendons and may cause an acute inflammatory syndrome of calcific tendinitis. Tenocytes are the stromal cells…
Abstract Number: 1050 • 2014 ACR/ARHP Annual Meeting
A Role for Purinergic Receptor Signalling in Basic Calcium Phosphate Crystal-Induced Inflammation
Clare C. Cunningham¹, Emma M. Corr¹, Geraldine M. McCarthy² and Aisling Dunne¹, ¹School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland, ²Medicine/Rheumatology, Mater Misericordiae University Hospital, Dublin 7, Ireland
Background/Purpose: Basic calcium phosphate (BCP) crystals are uniquely associated with osteoarthritis (OA). They are found in the majority of affected joints and closely correlate with…
Abstract Number: 50 • 2013 ACR/ARHP Annual Meeting
Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice
Jessica Bertrand¹, Tabea Kräft², Yvonne Nitschke³, Thelonius Hawellek⁴, Jan Hubert⁴, Lars Godmann⁵ and Thomas Pap⁵, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ²Inst, University Hospital Münster, Muenster, Germany, ³University Hospital Münster, Muenster, Germany, ⁴University Hospital Hamburg, Hamburg, Germany, ⁵Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…

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