Abstracts tagged "BAFF"

Abstract Number: 1741 • 2013 ACR/ARHP Annual Meeting
Correlation Of The Interferon Gene Signature With Systemic Lupus Erythematosus Disease Activity Is Dependent On The Associated Level Of The BAFF Gene Transcript
Michelle Petri¹, Laurence S. Magder², Hong Fang¹, Julie Czerkowicz³, Andrea Dearth³, Jadwiga Bienkowska⁴, Norm Allaire⁵, Patrick Cullen³, Alice Thai³ and Ann Ranger³, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Biogen Idec Inc, Cambridge, MA, ⁴Translational Medicine, Biogen Idec Inc., Cambridge, MA, ⁵Biogen Idec Inc., Cambridge, MA
Background/Purpose: The interferon alpha (IFN) gene signature is frequent in SLE (~50% of patients) and important in pathogenesis. However, multiple studies have found that the…
Abstract Number: 1742 • 2013 ACR/ARHP Annual Meeting
Effects Of Blisibimod, An Inhibitor Of B Cell Activating Factor, On Serum Immunoglobulins and Infection Risk In Patients With Systemic Lupus Erythematosus: Observations From The Placebo-Controlled Pearl-SC and Open-Label Extension Studies
Richard A. Furie¹, Matthew Thomas², Alvina Chu³, Renee S. Martin³, Colin Hislop³ and Morton A. Scheinberg⁴, ¹The Feinstein Institute for Medical Research and North Shore-Long Island Jewish Health System, Lake Success, NY, ²Health and Research Centre, Trivandrum, Kerala, India, ³Anthera Pharmaceuticals Inc, Hayward, CA, ⁴Rheumatology Hospital Abreu Sodre Pesquisa Clínica, São Paulo, Brazil
Background/Purpose: To evaluate the effects of subcutaneously-administered blisibimod (A-623, AMG 623), an inhibitor of B-cell activating factor (BAFF), on IgG, IgM and infection risk in patients…
Abstract Number: 1665 • 2013 ACR/ARHP Annual Meeting
B Cells Revisited In Giant Cell Arteritis
Kornelis S.M. van der Geest¹, Wayel H. Abdulahad², Gerda Horst², Caroline Roozendaal³, Abraham Rutgers², Annemieke M.H. Boots² and Elisabeth Brouwer², ¹Dept. of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Giant cell arteritis (GCA) is a primary vasculitis affecting large to medium-sized arteries. Ample evidence suggests that dendritic cells, T cells and monocytes/macrophages contribute…
Abstract Number: 2555 • 2012 ACR/ARHP Annual Meeting
Results of the Beliss Study, the First Open Phase 2 Study of Belimumab in Primary Sjogren’s Syndrome
Xavier Mariette¹, Luca Quartuccio², Raphaèle Seror³, Sara Salvin⁴, Frederic Desmoulins¹, Martina Fabris⁵, Sara Villeneuve⁶, Philippe Ravaud⁷ and Salvatore De Vita², ¹Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France, ²Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ³Rheumatology, Bicetre university hospital, LE Kremlin-Bicetre, France, ⁴Rheumatology Clinic, DSMB, University of Udine, Italy, Udine, Italy, ⁵Institute of Clinical Pathology, Udine, Italy, ⁶Epidemiology departement, Hospital Hotel dieu, Paris, France, ⁷Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France
Background/Purpose: The BAFF (or BLyS) cytokine plays a key role in pathogenesis of primary Sjogren’s syndrome (pSS). Belimumab, the first biological treatment inhibiting soluble BAFF,…
Abstract Number: 1785 • 2012 ACR/ARHP Annual Meeting
MiR-30* Family Negatively Regulates B-Cell Activating Factor (BAFF) Synthesis in Rheumatoid Synoviocytes
Ghada Alsaleh¹, Antoine Francois², Lucas Philippe¹, Jean Sibilia¹, Jacques-Eric Gottenberg¹, Philippe Georgel³ and Dominique Wachsmann¹, ¹Université de Strasbourg, EA4438 Laboratoire Physiopathologie des Arthrites, Illkirch-Strasbourg, France, ²Laboratory of Physiopathology of Arthritises, University of Strasbourg, Illkirch-Strasbourg, France, ³Université de Strasbourg, Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France
Background/Purpose: In rheumatoid arthritis (RA) resident cells of the joint, fibroblast-like synoviocytes (RA FLS) acquire an aggressive phenotype in response to extrinsic factors such as…
Abstract Number: 1758 • 2012 ACR/ARHP Annual Meeting
Serum BAFF Levels and Relationship with BAFF Binding Receptors in Patients with Rheumatoid Arthritis Relapsing After B Cell Depletion Therapy
Elena Becerra¹, Inmaculada de la Torre², Maria J. Leandro³ and Geraldine Cambridge³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ³Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom
Background/Purpose: B-cell-activating-factor (BAFF) coordinates differentiation of B cells into immunoglobulin secreting cells (ISC) by binding to 3 different receptors (BBRs), namely BAFF-R, transmembrane activator and…
Abstract Number: 1757 • 2012 ACR/ARHP Annual Meeting
B Cell Activating Factor Receptor Expression After Rituximab: Comparison of Patients with Rheumatoid Arthritis and Thrombotic Thrombocytopenic Purpura
Elena Becerra¹, Maria J. Leandro¹, Edward O. Heelas², John P. Westwood², Inmaculada de la Torre³, Marie A. Scully² and Geraldine Cambridge¹, ¹Rheumatology, Rheumatology, University College London, London, United Kingdom, ²Hematology, Hematology, University College London, London, United Kingdom, ³Rheumatology, Rheumatology, Gregorio Marañón Hospital, Madrid, Spain
Background/Purpose: B cell depletion therapy based on rituximab (RTX) is an effective therapy for Rheumatoid Arthritis (RA) and for Thrombotic Thrombocytopenic Purpura (TTP). Serum B…
Abstract Number: 1438 • 2012 ACR/ARHP Annual Meeting
Development of Systemic Lupus Erythematosus (SLE) in NZM 2328 Mice in the Absence of Any Single BAFF Receptor
Chaim O. Jacob¹, Ning Yu¹, Shunhua Guo¹, Noam Jacob¹, William J. Quinn III², Michael P. Cancro², Beatrice Goilav³, Chaim Putterman⁴, Thi-Sau Migone⁵ and William Stohl¹, ¹Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, ³Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵Human Genome Sciences, Rockville, MD
Background/Purpose: To determine the necessity for any individual BAFF receptor in the development of SLE. Methods: NZM 2328 wild-type (WT), NZM.Bcma-/-, NZM.Taci-/-, and NZM.Br3-/-mice were…
Abstract Number: 987 • 2012 ACR/ARHP Annual Meeting
Autoimmune Susceptibility Genes Are Regulators of Gene Expression Response to ER Stress
William E. Bernal¹, Michael P. Morley² and Vivian G. Cheung³, ¹Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pediatrics & Genetics, Howard Hughes Medical Institute, Chevy Chase, MD; University of Pennsylvania, Philadelphia, PA
Background/Purpose: Endoplasmic recticulum (ER) stress is caused by excessive demands on the protein-processing capacity of the ER; inefficiencies in response to ER stress lead to…
Abstract Number: 877 • 2012 ACR/ARHP Annual Meeting
Aberrant Expression of BAFF Receptor (BR3) in Peripheral Monocytes of Patients with Primary Sjögren’s Syndrome Impacts Abnormal Activation of BAFF Signaling Through IKK-Alphaand IKK-Beta
Keiko Yoshimoto¹, Maiko Tanaka², Masako Kojima², Hideko Ogata², Hideto Kameda¹, Katsuya Suzuki¹, Tohru Abe³ and Tsutomu Takeuchi⁴, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Dept Int Med Saitama Med Ctr, Saitama Medical School, Kawagoe-shi Saitama, Japan, ⁴Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: B cell activating factor belonging to the TNF superfamily (BAFF) regulates proliferation, differentiation and survival of B cells and plays a pivotal role in…
Abstract Number: L6 • 2012 ACR/ARHP Annual Meeting
Blisibimod, an Inhibitor of B Cell Activating Factor, in Patients with Moderate-to-Severe Systemic Lupus Erythematosus
Richard A. Furie¹, Morton A. Scheinberg², Gustavo Leon³, Edgar B. Ramiterre⁴, Matthew Thomas⁵, Renee S. Martin⁶ and Michelle Petri⁷, ¹The Feinstein Institute for Medical Research and North Shore-Long Island Jewish Health System, Lake Success, NY, ²Rheumatology Hospital Abreu Sodre Pesquisa Clínica, São Paulo, Brazil, ³Instituto De Ginecologia Y Reproduccion, Lima, Peru, ⁴Brokenshire Memorial Hospital, Davao City, Philippines, ⁵Health and Research Centre, Trivandrum, Kerala, India, ⁶Anthera Pharmaceuticals Inc, Hayward, CA, ⁷Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: To evaluate the efficacy, safety, and tolerability of subcutaneously-administered blisibimod (A-623, AMG 623), an inhibitor of soluble- and membrane-bound B-cell activating factor (BAFF), in patients…

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