Abstracts tagged "BAFF"

Abstract Number: 2610 • 2013 ACR/ARHP Annual Meeting
A New Pathogenic Role Of BAFF As a Critical Mediator Of Skin and Lung Fibrosis In Experimental Bleomycin-Induced Pulmonary Fibrosis, Systemic Sclerosis and Idiopathic Pulmonary Fibrosis
Antoine Francois¹, Pascal Schneider², Anne Davidson³, Emmanuel Chatelus⁴, Jérôme Avouac⁵, Yannick Allanore⁶, Bérengère Villeret⁷, Aurélie Gombault⁷, Paméla Gasse⁸, Sylvain Marchand Adam⁹, Bernhard Ryffel¹⁰, Siamak Bahram¹¹, Philippe Georgel¹², Jean Sibilia¹³, Isabelle Couillin⁸ and Jacques-Eric Gottenberg¹⁴, ¹Laboratory of Physiopathology of Arthritises, University of Strasbourg, Illkirch-Strasbourg, France, ²Department of Biochemistry, University of Lausanne, Lausanne, Switzerland, ³Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ⁴Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁵Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁶Rheumatology, Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁷Molecular Immunology and Embryology, University of Orleans and National Center for Scientific Research, Orléans, France, ⁸Molecular Immunology and Embryology, University of Orleans and National Center for Scientific Research, Orleans, France, ⁹Francois Rabelais University, National institute of the health and the medical research, Tours, France, ¹⁰UMR6218, Molecular Immunology, University and CNRS, 3b rue de la Ferollerie, Orleans, France, ¹¹Fédération of Translational Medicine of Strasbourg (FMTS), Immunorhumatology Molécular, Strasbourg, France, ¹²Université de Strasbourg, Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France, ¹³Rheumatology, CHU Hautepierre, Strasbourg, France, ¹⁴Strasbourg University Hospital, Strasbourg, France
Background/Purpose: Interstitial pneumonitis and lung fibrosis are frequent systemic complications of inflammatory arthritides, including systemic sclerosis (SSc), rheumatoid arthritis, or primary Sjögren’s syndrome. B lymphocytes…
Abstract Number: 2518 • 2013 ACR/ARHP Annual Meeting
Only BAFF mRNA, Not BAFF Protein Level In Blood, Is Associated With SLE Activity Over One Year
Eric Zollars¹, Hong Fang², Jadwiga Bienkowska³, Julie Czerkowicz⁴, Ann Ranger⁴, Norm Allaire⁵, Alice Thai⁴, Jeff Browning⁶, Laurence S. Magder⁷ and Michelle Petri², ¹Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Translational Medicine, Biogen Idec Inc., Cambridge, MA, ⁴Biogen Idec Inc, Cambridge, MA, ⁵Biogen Idec Inc., Cambridge, MA, ⁶Boston University School of Medicine, Boston, MA, ⁷Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD
Background/Purpose: B-cell–activating factor (BAFF; also known as B lymphocyte stimulator or BLyS) is a prominent factor in the selection and survival of B cells. BAFF…
Abstract Number: 1840 • 2013 ACR/ARHP Annual Meeting
Increased Expression of BAFF Receptor On Monocytes Is a Contributory Factor of Hypergammaglobulinemia in Patients With Primary Sjögren’s Syndrome
Keiko Yoshimoto¹, Maiko Tanaka², Masako Kojima², Hideko Ogata², Eriko Ishioka³, Ayumi Nishikawa², Katsuya Suzuki¹, Hideto Kameda¹, Tohru Abe⁴ and Tsutomu Takeuchi⁵, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ⁴Dept Int Med Saitama Med Ctr, Saitama Medical School, Kawagoe-shi Saitama, Japan, ⁵Keio University School of Medicine, Tokyo, Japan
Background/Purpose: BAFF (B cell stimulation factor belonging to TNF family) is a cytokine which is mainly produced by monocytes, dendritic cells and T cells. We…
Abstract Number: 2555 • 2012 ACR/ARHP Annual Meeting
Results of the Beliss Study, the First Open Phase 2 Study of Belimumab in Primary Sjogren’s Syndrome
Xavier Mariette¹, Luca Quartuccio², Raphaèle Seror³, Sara Salvin⁴, Frederic Desmoulins¹, Martina Fabris⁵, Sara Villeneuve⁶, Philippe Ravaud⁷ and Salvatore De Vita², ¹Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France, ²Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ³Rheumatology, Bicetre university hospital, LE Kremlin-Bicetre, France, ⁴Rheumatology Clinic, DSMB, University of Udine, Italy, Udine, Italy, ⁵Institute of Clinical Pathology, Udine, Italy, ⁶Epidemiology departement, Hospital Hotel dieu, Paris, France, ⁷Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France
Background/Purpose: The BAFF (or BLyS) cytokine plays a key role in pathogenesis of primary Sjogren’s syndrome (pSS). Belimumab, the first biological treatment inhibiting soluble BAFF,…
Abstract Number: 1785 • 2012 ACR/ARHP Annual Meeting
MiR-30* Family Negatively Regulates B-Cell Activating Factor (BAFF) Synthesis in Rheumatoid Synoviocytes
Ghada Alsaleh¹, Antoine Francois², Lucas Philippe¹, Jean Sibilia¹, Jacques-Eric Gottenberg¹, Philippe Georgel³ and Dominique Wachsmann¹, ¹Université de Strasbourg, EA4438 Laboratoire Physiopathologie des Arthrites, Illkirch-Strasbourg, France, ²Laboratory of Physiopathology of Arthritises, University of Strasbourg, Illkirch-Strasbourg, France, ³Université de Strasbourg, Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France
Background/Purpose: In rheumatoid arthritis (RA) resident cells of the joint, fibroblast-like synoviocytes (RA FLS) acquire an aggressive phenotype in response to extrinsic factors such as…
Abstract Number: 1758 • 2012 ACR/ARHP Annual Meeting
Serum BAFF Levels and Relationship with BAFF Binding Receptors in Patients with Rheumatoid Arthritis Relapsing After B Cell Depletion Therapy
Elena Becerra¹, Inmaculada de la Torre², Maria J. Leandro³ and Geraldine Cambridge³, ¹Rheumatology, University College London, London, United Kingdom, ²Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ³Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom
Background/Purpose: B-cell-activating-factor (BAFF) coordinates differentiation of B cells into immunoglobulin secreting cells (ISC) by binding to 3 different receptors (BBRs), namely BAFF-R, transmembrane activator and…
Abstract Number: 1757 • 2012 ACR/ARHP Annual Meeting
B Cell Activating Factor Receptor Expression After Rituximab: Comparison of Patients with Rheumatoid Arthritis and Thrombotic Thrombocytopenic Purpura
Elena Becerra¹, Maria J. Leandro¹, Edward O. Heelas², John P. Westwood², Inmaculada de la Torre³, Marie A. Scully² and Geraldine Cambridge¹, ¹Rheumatology, Rheumatology, University College London, London, United Kingdom, ²Hematology, Hematology, University College London, London, United Kingdom, ³Rheumatology, Rheumatology, Gregorio Marañón Hospital, Madrid, Spain
Background/Purpose: B cell depletion therapy based on rituximab (RTX) is an effective therapy for Rheumatoid Arthritis (RA) and for Thrombotic Thrombocytopenic Purpura (TTP). Serum B…
Abstract Number: 1438 • 2012 ACR/ARHP Annual Meeting
Development of Systemic Lupus Erythematosus (SLE) in NZM 2328 Mice in the Absence of Any Single BAFF Receptor
Chaim O. Jacob¹, Ning Yu¹, Shunhua Guo¹, Noam Jacob¹, William J. Quinn III², Michael P. Cancro², Beatrice Goilav³, Chaim Putterman⁴, Thi-Sau Migone⁵ and William Stohl¹, ¹Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, ³Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁴Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵Human Genome Sciences, Rockville, MD
Background/Purpose: To determine the necessity for any individual BAFF receptor in the development of SLE. Methods: NZM 2328 wild-type (WT), NZM.Bcma-/-, NZM.Taci-/-, and NZM.Br3-/-mice were…
Abstract Number: 987 • 2012 ACR/ARHP Annual Meeting
Autoimmune Susceptibility Genes Are Regulators of Gene Expression Response to ER Stress
William E. Bernal¹, Michael P. Morley² and Vivian G. Cheung³, ¹Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pediatrics & Genetics, Howard Hughes Medical Institute, Chevy Chase, MD; University of Pennsylvania, Philadelphia, PA
Background/Purpose: Endoplasmic recticulum (ER) stress is caused by excessive demands on the protein-processing capacity of the ER; inefficiencies in response to ER stress lead to…
Abstract Number: 877 • 2012 ACR/ARHP Annual Meeting
Aberrant Expression of BAFF Receptor (BR3) in Peripheral Monocytes of Patients with Primary Sjögren’s Syndrome Impacts Abnormal Activation of BAFF Signaling Through IKK-Alphaand IKK-Beta
Keiko Yoshimoto¹, Maiko Tanaka², Masako Kojima², Hideko Ogata², Hideto Kameda¹, Katsuya Suzuki¹, Tohru Abe³ and Tsutomu Takeuchi⁴, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Dept Int Med Saitama Med Ctr, Saitama Medical School, Kawagoe-shi Saitama, Japan, ⁴Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: B cell activating factor belonging to the TNF superfamily (BAFF) regulates proliferation, differentiation and survival of B cells and plays a pivotal role in…
Abstract Number: L6 • 2012 ACR/ARHP Annual Meeting
Blisibimod, an Inhibitor of B Cell Activating Factor, in Patients with Moderate-to-Severe Systemic Lupus Erythematosus
Richard A. Furie¹, Morton A. Scheinberg², Gustavo Leon³, Edgar B. Ramiterre⁴, Matthew Thomas⁵, Renee S. Martin⁶ and Michelle Petri⁷, ¹The Feinstein Institute for Medical Research and North Shore-Long Island Jewish Health System, Lake Success, NY, ²Rheumatology Hospital Abreu Sodre Pesquisa Clínica, São Paulo, Brazil, ³Instituto De Ginecologia Y Reproduccion, Lima, Peru, ⁴Brokenshire Memorial Hospital, Davao City, Philippines, ⁵Health and Research Centre, Trivandrum, Kerala, India, ⁶Anthera Pharmaceuticals Inc, Hayward, CA, ⁷Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: To evaluate the efficacy, safety, and tolerability of subcutaneously-administered blisibimod (A-623, AMG 623), an inhibitor of soluble- and membrane-bound B-cell activating factor (BAFF), in patients…

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