Abstracts tagged "BAFF and IL-6"

Abstract Number: 1958 • 2014 ACR/ARHP Annual Meeting
Pyrrolopyrimidine Derivatives That Inhibit Binding of BAFF to Its Receptor, BR3, Are Drug Candidates for Primary Sjögren’s Syndrome
Keiko Yoshimoto¹, Eriko Ishioka², Katsuya Suzuki¹, Takahiro Itou³, Tomohiro Sugano³, Hajime Yamada³, Ayumu Okuda³, Hiroyuki Ishiwata³, Takeshi Doi³, Takatsugu Hirokawa⁴ and Tsutomu Takeuchi⁵, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ³Tokyo New Drug Research Laboratories, Kowa Co., Ltd., Higashimurayama-City, Japan, ⁴Molecular Profiling Research Center for Drug Discovery (molprof), National Institute of Advanced Industrial Science and Technology (AIST), Koto-ku, Japan, ⁵Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose: We have been investigating the possible involvement of BAFF (B cell activating factor of TNF family) in the pathogenesis of primary Sjögren's syndrome (pSS).…

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