Abstracts tagged "BAFF and cytokines"

Abstract Number: 1109 • ACR/ARHP Annual Meeting 2015
Co-Crystal Structure of TACI and APRIL-BAFF-BAFF Heteromer Suggests That Charged Residues in APRIL and BAFF Dictate Their Receptor Binding Affinities
Xuliang Jiang¹, Thomas Tan², Klaus Maskos³, Alfred Lammens³, Pascal Schneider⁴ and Wolf Palinksy⁵, ¹Research and Development Institute, EMD Serono, Billerica, MA, ²EMD Serono Research, Billerica, MD, ³Proteros Biostructures GmbH, Planegg, Germany, ⁴Biochemistry, University of Lausanne, Epalinges, Switzerland, ⁵Global Biotech Development, Merck Serono, Aubonne, Switzerland
Background/Purpose: The human B cell survival factor, B cell activation factor (BAFF), and its closely related homologue, a proliferation-inducing ligand (APRIL), modulate B cell functions…