Abstracts tagged "B cells"

Abstract Number: 38 • 2017 ACR/ARHP Annual Meeting
Cytokine Production By CpG-Activated B Cells Require Glutaminolysis to Drive mTOR Activation, Aerobic Glycolysis and Mitochondrial Respiration
Matthew Cheung¹, Dongyue Huang¹, Emily Liu², Jennifer Ra² and Alfred Kim³, ¹Rheumatology, Washington University School of Medicine, Saint Louis, MO, ²IM/Rheumatology, Washington University School of Medicine, Saint Louis, MO, ³IM/Rheumatology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine secretion. A wide variety of stimuli can activate B cells to produce cytokines…
Abstract Number: 1466 • 2017 ACR/ARHP Annual Meeting
The Effects of Rituximab and B-Cells Depletion on the Inflammatory and Pro-Thrombotic Profile of Leucocytes of Rheumatoid Arthritis Patients and on the Vascular Endothelium
Irene Cecchi¹, Carlos Perez-Sanchez², Patricia Ruiz-Limon³, Ivan Arias de la Rosa³, Maria Carmen Abalos-Aguilera³, Yolanda Jiménez-Gómez², Rafaela Ortega-Castro², Eduardo Collantes-Estévez², Alejandro Escudero-Contreras³, Massimo Radin⁴, Nuria Barbarroja², Dario Roccatello⁵, Savino Sciascia⁶ and Chary Lopez-Pedrera⁷, ¹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁵Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, ⁷IMIBIC/Reina Sofia Hospital/ University of Cordoba, Cordoba, Spain
Background/Purpose: Cardiovascular disease (CVD) constitutes a relevant cause of morbidity and mortality in Rheumatoid Arthritis (RA) patients. Rituximab (RTX) has been proved to be effective…
Abstract Number: 40 • 2017 ACR/ARHP Annual Meeting
B-Cell Attracting Chemokine-1 (BCA-1) and Macrophage Inflammatory Protein-3 Alpha (MIP-3α) Act Synergistically in the Recruitment of B Cells in the Rheumatoid Synovium
Estefanía Armas-González¹, María Jesús Domínguez-Luis², María Teresa Arce-Franco³, Javier Castro-Hernández³, Vanesa Hernandez⁴, Sagrario Bustabad⁵, Alberto Cantabrana-Alutiz⁶ and Federico Díaz-González⁷, ¹Universidad de La Laguna, Departamento de Medicina Física y Farmacología, Facultad de Medicina, La Laguna, Tenerife, Spain, ²Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Spain, ³Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁴Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, S/C Tenerife, Spain, ⁵Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁶Servicio de Reumatología. Hospital Universitario Nuestra Señora de Candelaria, La Laguna, Tenerife, Spain, ⁷Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Background/Purpose: B cells are recognized as key players in the pathogenesis of rheumatoid arthritis (AR) through the production of autoantibodies, the local production of proinflammatory…
Abstract Number: 1748 • 2017 ACR/ARHP Annual Meeting
Cbl-b Associates with Bcl-6 and Is Differentially Expressed in Circulating Follicular T Helper Cells of Patients with Systemic Lupus Erythematosus
Jeffrey Hampton¹, Giancarlo R. Valiente², Armin Munir³, Takuma Tsuzuki Wada³, William Willis³, Nicholas A. Young³, Lai-Chu Wu⁴, Jian Zhang⁵ and Wael Jarjour³, ¹Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Activation of polyclonal CD4+ T cells and B cells is a hallmark of human and murine lupus, which suggests a global defect in the…
Abstract Number: 42 • 2017 ACR/ARHP Annual Meeting
Resveratrol Regulates Sirt1 to Control B Cells Activation and Plasma B Cells Differentiation
Ting Wang¹, Xing Song², Xiaofang Luo², Mengtao Li² and Xiaofeng Zeng¹, ¹Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-systemic autoimmune disease characterized by B cell hyperactivation and the production of autoantibodies. Histone deacetylase, Sirtuin1 (Sirt1) has…
Abstract Number: 1782 • 2017 ACR/ARHP Annual Meeting
Mycophenolic Acid Decreases IL-10 and IL-6 Production By B Cells of Granulomatosis with Polyangiitis Patients and Healthy Controls in Vitro
Anouk von Borstel¹, Wayel H. Abdulahad², Abraham Rutgers², Judith Land², Coen A. Stegeman¹, Peter Heeringa³ and Jan-Stephan F. Sanders¹, ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Granulomatosis with polyangiitis (GPA) is a relapsing autoimmune disease affecting small- to medium-sized blood vessels. B cells are thought to play an important antibody-independent…
Abstract Number: 43 • 2017 ACR/ARHP Annual Meeting
Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE
Daniele Mauro¹, Victoria Tsang², Isabelle A. Clayton-Lucey³, Sara Pagani², Farah Alam², Elena Pontarini², Alessandra Nerviani², Angela Pakozdi⁴, Andrea Cove-Smith⁴, Ravindra Rajakariar⁴, Debasish Pyne⁴, Timothy J Vyse⁵, Costantino Pitzalis² and Myles J. Lewis^4,6, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ²Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, United Kingdom, ⁴Barts Lupus Centre, Barts Health NHS Trust, London, United Kingdom, ⁵Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom, ⁶Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: A single risk haplotype spanning UBE2L3 is strongly associated with SLE and multiple autoimmune diseases. The E2 ubiquitin-conjugating enzyme UBE2L3 regulates TNFα and CD40…
Abstract Number: 1834 • 2017 ACR/ARHP Annual Meeting
Selective Inhibitors of Nuclear Export Prevent Lupus Progression By Targeting Germinal Center Formation and Autoreactive Antibody Secreting Cells
Javier Rangel-Moreno¹, Jennifer Barnard², Shelton Cochran³, Margaret Lee³, Sharon Tamir³ and Jennifer H. Anolik⁴, ¹Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Medicine-Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ³Karyopharm Therapeutics, Newton, MA, ⁴Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: There is great interest in developing new treatment approaches for systemic lupus erythematosus (SLE), but the biologic therapies under investigation over the past several…
Abstract Number: 19 • 2017 ACR/ARHP Annual Meeting
The Transcription Factor Specificity Protein 1 up-Regulates IL-21 Receptor Expression on B Cells in Rheumatoid Arthritis Leading to Altered Cytokine Production and Maturation
Elizabeth Dam¹, Alison Maier¹, Anne Hocking¹, Jeffrey Carlin² and Jane H. Buckner¹, ¹Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Rheumatology, Virginia Mason Medical Center, Seattle, WA
Background/Purpose: Growing evidence suggests that IL-21 has a role in B cell dysfunction in rheumatoid arthritis (RA). Previous studies have reported that IL-21 levels are…
Abstract Number: 44 • 2017 ACR/ARHP Annual Meeting
Characterization of Novel Stromal-Derived Autoantigens Recognized By RA Synovial Monoclonal Antibodies
Elisa Corsiero¹, Lucas Jagemann¹, Costantino Pitzalis² and Michele Bombardieri³, ¹Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ³Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: We previously showed that up to 40% of RA synovial recombinant monoclonal antibodies (RA-rmAbs) generated from germinal center-like structure (GC-LS+) RA synovium recognize citrullinated…
Abstract Number: 1837 • 2017 ACR/ARHP Annual Meeting
Development of Murine SLE in the Absence of BAFF
William Stohl¹, Ning Yu¹, Samantha Chalmers², Chaim Putterman³ and Chaim O. Jacob¹, ¹Division of Rheumatology, Keck School of Medicine of University of Southern California, Los Angeles, CA, ²Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: BAFF is a vital survival and differentiation factor for B cells. In human SLE, clinical efficacy with any of 4 different BAFF antagonists is…
Abstract Number: 21 • 2017 ACR/ARHP Annual Meeting
Reciprocal Regulation of B Cells on Bleomycin-Induced Scleroderma Model: IL-6-Producing Effector B Cells Play a Pathogenic Role, While IL-10-Producing Regulatory B Cells Play a Protective Role
Takashi Matsushita¹, Yasuhito Hamaguchi¹, Minoru Hasegawa², Manabu Fujimoto³ and Kazuhiko Takehara⁴, ¹Department of Dermatology, Kanazawa University, kanazawa, Japan, ²Department of Dermatology, University of Fukui, Fukui, Japan, ³Department of Dermatology, University of Tsukuba, Tsukuba, Japan, ⁴Department of Dermatology, Kanazawa University, Kanazawa, Japan
Background/Purpose: IL-10-producing regulatory B (Breg) cells negatively regulate autoimmune diseases. We reported that Breg cells play a protective role in a mouse model of systemic…
Abstract Number: 46 • 2017 ACR/ARHP Annual Meeting
Secondary Light Chain Editing and Allelic Inclusion in Antibody Secreting Cells from the Minor Salivary Gland
Kristi A. Koelsch¹, Kenneth Smith², Astrid Rasmussen³, C. Erick Kaufman⁴, David M. Lewis⁵, Lida Radfar⁶, Christopher J Lessard², Biji T Kurien², Judith A. James³, Kathy L. Sivils³, A. Darise Farris⁷ and R. Hal Scofield⁸, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Okalahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ⁵Department of Oral Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁶Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Heavy and light chain gene usage and mutational analyses of the Ig variable regions (V-regions) enable the identification of gene usage within B cell…
Abstract Number: 1846 • 2017 ACR/ARHP Annual Meeting
Increased CD38hiCD27+ Plasmablast Frequency in Remission Predicts Relapsing Disease in Granulomatosis with Polyangiitis Patients
Anouk von Borstel¹, Wayel H. Abdulahad², Abraham Rutgers², Judith Land², Coen A. Stegeman¹, Peter Heeringa³ and Jan-Stephan F. Sanders¹, ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Patients with granulomatosis with polyangiitis (GPA) are prone to disease relapse. Changes in anti-neutrophil cytoplasmic autoantibodies (ANCA) levels can predict relapses in individual patients…
Abstract Number: 22 • 2017 ACR/ARHP Annual Meeting
Bone Regulatory Cytokine Production By B Cells in Rheumatoid Arthritis Is Dependent on NF-κb Activation and Autophagy Pathways
Jason Glanzman¹, Nida Meednu¹, Victor Wang¹, Wen Sun², Lianping Xing³ and Jennifer H. Anolik¹, ¹Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Nanjing Medical University, Nanjing, China, ³Pathology & Lab Medicine, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease that often leads to joint damage, a process mediated by an imbalance between bone resorption and…

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