Abstracts tagged "B cells"

Abstract Number: 25 • 2018 ACR/ARHP Annual Meeting
Circulating CD24hiCD38hi Regulatory B-Cells Influence Th17-Cell Responses in Patients with Granulomatosis with Polyangiitis
Anouk von Borstel¹, Lucas L. Lintermans², P Heeringa³, Abraham Rutgers², Coen A. Stegeman¹, Jan-Stephan F. Sanders¹ and Wayel H. Abdulahad², ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: To investigate whether there is a direct relation between expanded proportions of Th17-effector memory (ThEM17) cells and diminished proportions of regulatory B-cells (Bregs) in…
Abstract Number: 1095 • 2018 ACR/ARHP Annual Meeting
IFN Gene Expression Correlates with Frequency of Circulating Switched Memory B-Cells in Patients with Incomplete Systemic Lupus Erythematosus
Wietske Lambers¹, Geert Lanting¹, Wayel H. Abdulahad², Hendrika Bootsma², Johanna Westra² and Karina de Leeuw³, ¹Rheumatology/Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Incomplete systemic lupus erythematosus (iSLE) includes patients with typical features of SLE, who do not meet classification criteria. Still, up to 50% will develop…
Abstract Number: 2885 • 2018 ACR/ARHP Annual Meeting
Expansion of Activated PD-1+ ICOS+ T Follicular and Peripheral Helper Cells in Primary Sjögren’s Syndrome Associates with Abnormalities in B Cell Compartment
Nida Meednu¹, Jennifer Albrecht², Madhu Ramaswamy³, Jeffrey Riggs⁴, Alex Rosenberg⁵, Jamie Biear⁶, Ralf G. Thiele⁷, Andreea Coca², Gianluca Carlesso³ and Jennifer Anolik², ¹Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY, ³MedImmune LLC, Gaithersburg, MD, ⁴Respiratory, Inflammation and Autoimmunity (RIA), MedImmune LLC, Gaithersburg, MD, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁷Division of Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by immune cell infiltration in the salivary glands resulting in ocular and oral dryness.…
Abstract Number: 1 • 2018 ACR/ARHP Annual Meeting
Profiling of B-Cell Related Factors and Its Decoy Receptors in Rheumatoid Arthritis: Potential Clues for Patient Stratification
Javier Rodríguez-Carrio^1,2, Mercedes Alperi-López³, Patricia López¹, Francisco Javier Ballina-García⁴ and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain, ³Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ⁴Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain
Background/Purpose: B-cell over-activation plays a key role in the pathogenesis of rheumatoid arthritis (RA), thus being recognized as a therapeutic target. However, the activation of…
Abstract Number: 26 • 2018 ACR/ARHP Annual Meeting
Hints for Catecholamine-Driven Autocrine Mechanisms to Regulate Regulatory B Cells
Nadine Honke¹, Torsten Lowin², Birgit Opgenoorth¹, Matthias Schneider¹, Georg Pongratz¹ and Katharina Krebber¹, ¹Rheumatology Policlinic & Hiller Research Unit, Medical Faculty, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany, ²Department and Hiller Research Center for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease affecting 1% of the worldwide population and characterized by synovial hypertrophy and chronic joint inflammation. In recent…
Abstract Number: 1582 • 2018 ACR/ARHP Annual Meeting
Clinical Correlations and Expression Pattern of the Autoimmunity Susceptibility Factor Diora-1 in Primary Sjögren’s Syndrome
Lauro Meneghel¹, Lara Aqrawi^1,2,3, Lara Mentlein¹, Albin Björk¹, Gudny Ella Thorlacius¹, Margarita Ivanchenko¹, Jorge Ramírez¹, Kathrine Skarstein^2,4, Marika Kvarnström¹, Susanna Brauner¹, Alexander Espinosa¹ and Marie Wahren-Herlenius¹, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²The Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Bergen, Norway, ³Department of Oral Surgery and Oral Medicine, Institute of Clinical Odontology, University of Oslo, Oslo, Norway, Oslo, Norway, ⁴Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway
Background/Purpose: Genome-wide association studies of multiple autoimmune diseases, including primary Sjögren’s syndrome (pSS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have revealed an association…
Abstract Number: 2946 • 2018 ACR/ARHP Annual Meeting
T Peripheral Helper Cells Are Expanded in the Circulation of Active SLE Patients and Correlate with CD21low B Cells
Deepak Rao¹, Alexandra Bocharnikov², Chamith Fonseka³, Joshua Keegan², Betty Diamond⁴, Jennifer Anolik⁵, Peter Nigrovic¹, Soumya Raychaudhuri^3,6, James A. Lederer⁷ and Michael Brenner⁸, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Autoimmune Musculoskeletal and Hematopoietic Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ⁵Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁶Program in Medical and Population Genetics, Broad Institute of Massachusetts Technical Institute, Harvard University, Cambridge, MA, ⁷Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Pathologic T cell-B cell interactions and production of autoantibodies are hallmark features of SLE. T follicular helper (Tfh) cells are generally considered the principal…
Abstract Number: 38 • 2017 ACR/ARHP Annual Meeting
Cytokine Production By CpG-Activated B Cells Require Glutaminolysis to Drive mTOR Activation, Aerobic Glycolysis and Mitochondrial Respiration
Matthew Cheung¹, Dongyue Huang¹, Emily Liu², Jennifer Ra² and Alfred Kim³, ¹Rheumatology, Washington University School of Medicine, Saint Louis, MO, ²IM/Rheumatology, Washington University School of Medicine, Saint Louis, MO, ³IM/Rheumatology, Washington University School of Medicine, St. Louis, MO
Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine secretion. A wide variety of stimuli can activate B cells to produce cytokines…
Abstract Number: 1466 • 2017 ACR/ARHP Annual Meeting
The Effects of Rituximab and B-Cells Depletion on the Inflammatory and Pro-Thrombotic Profile of Leucocytes of Rheumatoid Arthritis Patients and on the Vascular Endothelium
Irene Cecchi¹, Carlos Perez-Sanchez², Patricia Ruiz-Limon³, Ivan Arias de la Rosa³, Maria Carmen Abalos-Aguilera³, Yolanda Jiménez-Gómez², Rafaela Ortega-Castro², Eduardo Collantes-Estévez², Alejandro Escudero-Contreras³, Massimo Radin⁴, Nuria Barbarroja², Dario Roccatello⁵, Savino Sciascia⁶ and Chary Lopez-Pedrera⁷, ¹Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁵Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy, ⁷IMIBIC/Reina Sofia Hospital/ University of Cordoba, Cordoba, Spain
Background/Purpose: Cardiovascular disease (CVD) constitutes a relevant cause of morbidity and mortality in Rheumatoid Arthritis (RA) patients. Rituximab (RTX) has been proved to be effective…
Abstract Number: 40 • 2017 ACR/ARHP Annual Meeting
B-Cell Attracting Chemokine-1 (BCA-1) and Macrophage Inflammatory Protein-3 Alpha (MIP-3α) Act Synergistically in the Recruitment of B Cells in the Rheumatoid Synovium
Estefanía Armas-González¹, María Jesús Domínguez-Luis², María Teresa Arce-Franco³, Javier Castro-Hernández³, Vanesa Hernandez⁴, Sagrario Bustabad⁵, Alberto Cantabrana-Alutiz⁶ and Federico Díaz-González⁷, ¹Universidad de La Laguna, Departamento de Medicina Física y Farmacología, Facultad de Medicina, La Laguna, Tenerife, Spain, ²Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Spain, ³Laboratorio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁴Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, S/C Tenerife, Spain, ⁵Rheumatology, Servicio de Reumatología. Hospital Universitario de Canarias, La Laguna, Tenerife, Spain, ⁶Servicio de Reumatología. Hospital Universitario Nuestra Señora de Candelaria, La Laguna, Tenerife, Spain, ⁷Servicio de Reumatología. Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Background/Purpose: B cells are recognized as key players in the pathogenesis of rheumatoid arthritis (AR) through the production of autoantibodies, the local production of proinflammatory…
Abstract Number: 1748 • 2017 ACR/ARHP Annual Meeting
Cbl-b Associates with Bcl-6 and Is Differentially Expressed in Circulating Follicular T Helper Cells of Patients with Systemic Lupus Erythematosus
Jeffrey Hampton¹, Giancarlo R. Valiente², Armin Munir³, Takuma Tsuzuki Wada³, William Willis³, Nicholas A. Young³, Lai-Chu Wu⁴, Jian Zhang⁵ and Wael Jarjour³, ¹Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Microbial Infection and Immunity, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Activation of polyclonal CD4+ T cells and B cells is a hallmark of human and murine lupus, which suggests a global defect in the…
Abstract Number: 42 • 2017 ACR/ARHP Annual Meeting
Resveratrol Regulates Sirt1 to Control B Cells Activation and Plasma B Cells Differentiation
Ting Wang¹, Xing Song², Xiaofang Luo², Mengtao Li² and Xiaofeng Zeng¹, ¹Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-systemic autoimmune disease characterized by B cell hyperactivation and the production of autoantibodies. Histone deacetylase, Sirtuin1 (Sirt1) has…
Abstract Number: 1782 • 2017 ACR/ARHP Annual Meeting
Mycophenolic Acid Decreases IL-10 and IL-6 Production By B Cells of Granulomatosis with Polyangiitis Patients and Healthy Controls in Vitro
Anouk von Borstel¹, Wayel H. Abdulahad², Abraham Rutgers², Judith Land², Coen A. Stegeman¹, Peter Heeringa³ and Jan-Stephan F. Sanders¹, ¹Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Granulomatosis with polyangiitis (GPA) is a relapsing autoimmune disease affecting small- to medium-sized blood vessels. B cells are thought to play an important antibody-independent…
Abstract Number: 43 • 2017 ACR/ARHP Annual Meeting
Regulation of TLR7 Signalling By UBE2L3 Dependent Linear Ubiquitination Explains Dimethyl Fumarate Suppression of Autoreactive B Cell Development in SLE
Daniele Mauro¹, Victoria Tsang², Isabelle A. Clayton-Lucey³, Sara Pagani², Farah Alam², Elena Pontarini², Alessandra Nerviani², Angela Pakozdi⁴, Andrea Cove-Smith⁴, Ravindra Rajakariar⁴, Debasish Pyne⁴, Timothy J Vyse⁵, Costantino Pitzalis² and Myles J. Lewis^4,6, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ²Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, ³Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, United Kingdom, ⁴Barts Lupus Centre, Barts Health NHS Trust, London, United Kingdom, ⁵Division of Genetics and Molecular Medicine, King's College London, Guy's Hospital, London, United Kingdom, ⁶Rheumatology, Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: A single risk haplotype spanning UBE2L3 is strongly associated with SLE and multiple autoimmune diseases. The E2 ubiquitin-conjugating enzyme UBE2L3 regulates TNFα and CD40…
Abstract Number: 1834 • 2017 ACR/ARHP Annual Meeting
Selective Inhibitors of Nuclear Export Prevent Lupus Progression By Targeting Germinal Center Formation and Autoreactive Antibody Secreting Cells
Javier Rangel-Moreno¹, Jennifer Barnard², Shelton Cochran³, Margaret Lee³, Sharon Tamir³ and Jennifer H. Anolik⁴, ¹Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Medicine-Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ³Karyopharm Therapeutics, Newton, MA, ⁴Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: There is great interest in developing new treatment approaches for systemic lupus erythematosus (SLE), but the biologic therapies under investigation over the past several…

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