Abstracts tagged "B cells"

Abstract Number: 3105 • 2015 ACR/ARHP Annual Meeting
The RA Immune System Recreated in Immunodeficient Mice By Thymic Differentiation from RA Patients’ Hematopoietic Stem Cells Exhibits Marked CD4 T Cell Activation and Differentiation
Robert Winchester¹, Chiara Borsotti², Nichole Danzl², Jon Giles³, Joan M. Bathon⁴ and Megan Sykes², ¹Dept of Pediatrics & Medicine, Columbia University, New York, NY, ²Medicine, Columbia University, New York, NY, ³Rheumatology, Columbia University Medical Center, NY, NY, ⁴Medicine, Columbia University, College, New York, NY
Background/Purpose: We recently reported an advance in modeling the human immune system in mice, (Kalscheuer et al. Sci Transl Med 2012) involving maturation of patient…
Abstract Number: 1099 • 2015 ACR/ARHP Annual Meeting
Single Cell RNA-Seq Analysis of Citrullinated Alpha-Enolase Peptide-Specific B Cells in RA
Yogita Ghodke-Puranik¹, Na Zhang², Jessica M. Dorschner¹, Anna Shmagel³, Zhongbo Jin¹, Philip Titcombe⁴, Timothy B. Niewold¹ and Daniel Mueller⁵, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Medicine, University of Minnesota Medical School, Minneapolis, MN, ³Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ⁴University of Minnesota Medical School, Minneapolis, MN, ⁵Medicine/Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: The high prevalence of citrullinated protein antibodies and improvement following rituximab anti-CD20 therapy both suggest that B cells are important in the pathogenesis of…
Abstract Number: 1124 • 2015 ACR/ARHP Annual Meeting
Bruton’s Tyrosine Kinase Levels Are Increased in B Cells from Patients with Primary Sjögren’s Syndrome
Odilia B.J. Corneth¹, Gwenny Verstappen², Marjolein de Bruijn¹, Erlin A. Haacke³, Arjan Vissink⁴, Hendrika Bootsma⁵, Frans G.M. Kroese² and Rudi W. Hendriks¹, ¹Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Pathology, University Medical Center Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Upon B cell receptor stimulation, B cells increase protein expression levels of the key downstream signaling molecule Bruton’s tyrosine kinase (BTK). BTK-transgenic mice that…
Abstract Number: 3152 • 2015 ACR/ARHP Annual Meeting
The IL-21 Signaling Pathway Is Enhanced in RA B Cells and Has the Potential to Alter Development and Cytokine Production in RA B Cells
Jane H. Buckner¹ and Elizabeth Samuelson², ¹Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: B cells have been implicated in the development of rheumatoid arthritis (RA) based on their production of autoantibodies and cytokines as well as the…
Abstract Number: 1100 • 2015 ACR/ARHP Annual Meeting
Citrullinated Antigen-Specific B Cells in Peripheral Blood and Synovial Fluid of Patients with Rheumatoid Arthritis: Identification and Phenotypic Characterization
Priscilla Kerkman¹, Ellen I.H. van der Voort¹, Arnaud Zaldumbide², Emeline Fabre¹, Yoann Rombouts¹, Theo Rispens³, Gertjan Wolbink⁴, Rob Hoeben², Hergen Spits⁵, Dominique Baeten⁶, T. W. J. Huizinga¹, René E. M. Toes¹ and Hans Ulrich Scherer¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands, ³Sanquin Research, Amsterdam, Netherlands, ⁴Immunopathology, Sanquin Research, Amsterdam, Netherlands, ⁵Department of Cell Biology and Histology, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ⁶Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the presence of anti-citrullinated protein antibodies (ACPA) in the majority of patients. ACPA represent highly disease-specific biomarkers that…
Abstract Number: 1249 • 2015 ACR/ARHP Annual Meeting
Differential Expression of SLE Susceptibility Genes By Interferon-Alpha and the HLA-DRB1*03:01 Haplotype in Ex Vivo B Cells
Carolina Duarte¹, Lora Boteva², Timothy Vyse¹ and Michelle Fernando¹, ¹Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ²MRC Human Genetics Unit, University of Edinburgh, Edinburgh, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex genetic autoimmune disease characterized by autoantibody production and up-regulation of type 1 interferons (IFNs). The strongest genetic association…
Abstract Number: 3153 • 2015 ACR/ARHP Annual Meeting
Microrna-155/PU.1 Axis As an Epigenetic Regulator of B-Cells in Rheumatoid Arthritis
Stefano Alivernini¹, Barbara Tolusso¹, Mariola Kurowska-Stolarska², Roberta Benvenuto³, Antonella Mangoni³, Silvia Canestri¹, Luca Petricca¹, Anna Laura Fedele¹, Maria Rita Gigante¹, Clara Di Mario¹, Elisa Gremese¹, Iain B. McInnes² and Gianfranco Ferraccioli¹, ¹Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, ²Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Division of Pathology - Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: MicroRNA-155(miR-155) has been shown to be a key regulator of B cell biology by PU.1 regulation. However, the role of miR-155 in the activation…
Abstract Number: 1102 • 2015 ACR/ARHP Annual Meeting
CD19+CD24-CD38hi B-Cell Subset: A Potential Biomarker for IgG4-Related Disease
Wen Zhang^1,2, Wei Lin³, Yu Chen⁴, Yunjiao Yang⁴, Hua Chen⁴, QingJun Wu⁴, Yunyun Fei⁴, Chaojun Hu⁴, Yongzhe Li³, Xuan Zhang³, Yan Zhao⁴, Fengchun Zhang³, Xiaofeng Zeng⁴ and Peter E. Lipsky⁵, ¹Rheuamtology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, ³Peking Union Medical College Hospital, Beijing, China, ⁴Rheumatology, Peking Union Medical College Hospital, Beijing, China, ⁵Bldg 10 Rm 6d47c, National Institutes of Health, Bethesda, MD
Background/Purpose: To investigate a B-cell subpopulation, exhibiting CD19+CD24-CD38hi phenotype, can be a biomarker for diagnosis and disease activity in IgG4 related disease (IgG4-RD). Methods: Circulating…
Abstract Number: 1380 • 2015 ACR/ARHP Annual Meeting
Characterization of Lymphocytes Subsets in Peripheral Blood of Untreated IgG4-Related Disease Patients
Aurélie Grados¹, Mikael Ebbo¹, Christelle Piperoglou², Matthieu Groh³, Alexis Regent⁴, Maxime Samson⁵, Benjamin Terrier⁶, Nathalie Morel⁷, Sylvain Audia⁵, Francois Maurier⁸, Julie Graveleau⁹, Mohamed Hamidou¹⁰, Amandine Forestier¹¹, Sylvain Palat¹², Emanuelle Bernit¹, Gilles Kaplanski¹³, Frederique Retornaz¹⁴, Bernard Bonotte⁵, Catherine Farnarier¹⁵, Jean-Robert Harle¹⁶, Nathalie Costedoat-Chalumeau⁷, Frederic Vely¹⁷ and Nicolas Schleinitz¹, ¹Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ²Immunology, CIML, AP-HM, Marseille, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁴Service de médecine interne, Hôpital Cochin, Paris, France, ⁵Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ⁶Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁸HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁹Medecine Interne Hotel Dieu Nantes, Nantes, France, ¹⁰Internal Medicine Department, Nantes University Hospital, Nantes, France, ¹¹Internal Medicine, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France, ¹²Service de Medecine Interne, CHU limoges, Limoges, France, ¹³Internal Medicine hopital conception, Aix-Marseille Université, Marseille, France, ¹⁴Conseil General 13 cellule recherche, Marseille, France, ¹⁵Laboratoire d'immunologie, Hopital de la Conception, Marseille, France, ¹⁶Internal Medicine, Aix-Marseille Université, APHM, Marseille, France, ¹⁷CIML, Laboratoire d'Immunologie Conception AP-HM, Aix-Marseille université, Marseille, France
Background/Purpose: IgG4-related disease (IgG4-RD) is associated with characteristic pathological changes including lymphoplasmocytic infiltration with abundant IgG4 positive plasma cells, storiform fibrosis and obliterative phlebitis. The…
Abstract Number: 3155 • 2015 ACR/ARHP Annual Meeting
Bob1 Expression Is Elevated in Rheumatoid Synovium and Its Expression in B Cells Is Required for Development of Collagen-Induced Arthritis
Maartje Levels^1,2,3, Melissa van Tok^2,3,4, Tineke Cantaert^2,3, Frans G.M. Kroese⁵, Hergen Spits⁶, Dominique Baeten^2,3,4 and Nataliya Yeremenko^1,2,3, ¹Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, ²Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Laboratory of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁶Department of Cell Biology and Histology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a prototypic autoimmune disease characterized by a prominent humoral autoimmunity. Of particular relevance is the local production of autoantibodies and…
Abstract Number: 1103 • 2015 ACR/ARHP Annual Meeting
Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion By Human Regulatory B Cells
Charlotte Hua¹, Rachel Audo², Michael Hahne², Bernard Combe³, Jacques Morel³ and Claire I. Daien³, ¹Department of Rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ²IGMM-CNRS UMR5535, Montpellier, France, ³Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France
Background/Purpose: B cells can have a negative regulatory role, mainly mediated by interleukin 10 (IL-10) and we recently showed that IL-10 producing B cells (B10…
Abstract Number: 1641 • 2015 ACR/ARHP Annual Meeting
B Cell Depletion with Rituximab in Patients with Rheumatoid Arthritis: Multiplex Bead Array Reveals Kinetics of IgG and IgA Autoantibodies to Citrullinated Antigens
Geraldine Cambridge¹, Lauren J. Lahey², Maria J. Leandro¹, William H. Robinson³ and Jeremy Sokolove⁴, ¹Rheumatology, University College London, London, United Kingdom, ²Medicine, VA Palo Alto HealthCare System and Stanford University, Palo Alto, CA, ³VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁴Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA
Background/Purpose: Seropositivity for rheumatoid factors and anti-citrullinated (Cit) protein antibodies (ACPA) are the strongest predictor for clinical response to rituximab (RTX) in rheumatoid arthritis (RA).…
Abstract Number: 3157 • 2015 ACR/ARHP Annual Meeting
B Cell Profile As a Biomarker of Disease Segmentation and Flare Prognosis in SLE
Chungwen Wei¹, Bridget Neary², Jamie Biear³, Jennifer Barnard^3,4, Michelle Petri⁵, Alex Rosenberg⁶, Jennifer H. Anolik⁷ and Ignacio Sanz¹, ¹Rheumatology, Emory University, Atlanta, GA, ²Emory University, Atlanta, GA, ³Rheumatology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁶University of Rochester, Rochester, NY, ⁷University of Rochester Medical Center, Rochester, NY
Background/Purpose: B cell abnormalities in SLE are well-established contributors to disease pathogenesis. Perturbation of B cell homeostasis in SLE is often described separately for each…
Abstract Number: 1104 • 2015 ACR/ARHP Annual Meeting
Mouse B Cells Require Glucose and Free Fatty Acids As Carbon Sources for Cytokine and Chemokine Secretion
Doujiao Wu¹, Dongyue Huang², Edward Pearce¹ and Alfred Kim², ¹Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, ²Rheumatology, Washington University School of Medicine, Saint Louis, MO
Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine and chemokine secretion. A wide variety of stimuli can activate B cells including…
Abstract Number: 1667 • 2015 ACR/ARHP Annual Meeting
Clinical Parameters and B Cell Subsets As Biomarkers of Response to Tocilizumab in Rheumatoid Arthritis
Anna Laura Fedele, Barbara Tolusso, Elisa Gremese, Silvia Canestri, Clara Di Mario, Marcin Nowik and Gianfranco Ferraccioli, Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Tocilizumab (TCZ) is an effective treatment for Rheumatoid Arthritis (RA) and it is a modifier of B cell subsets in vivo, inducing changes in…

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