Abstracts tagged "B cells and Wegener’s granulomatosis"

Abstract Number: 925 • 2013 ACR/ARHP Annual Meeting
B Cell Subset Phenotypes In Patients With Granulomatosis With Polyangiitis (Wegener’s)
Atul A. Khasnis¹, Carol A. Langford², Leonard H. Calabrese³, Julia M. Sugalski⁴, Michael Lederman⁵ and Donald D. Anthony⁶, ¹Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, ²Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH, ⁴Medicine/infectious disease, Case Western Reserve University, Cleveland, OH, ⁵Infectious Diseases, Case Western Reserve University, Cleveland, OH, ⁶Medicine, Case Western Reserve University, Cleveland, OH
Background/Purpose: B cells are pathogenic in granulomatosis with polyangiitis (Wegener’s) (GPA). Rituximab (RTX), an anti-CD20 monoclonal antibody, is effective therapy however B cell reconstitution patterns…
Abstract Number: 732 • 2013 ACR/ARHP Annual Meeting
Expansion Of IgA-Plasma Cells As a Sign For Ear-Nose-Throat-Involvment In Granulomatosis With Polyangiitis?
Bimba F. Hoyer^1,2, Adriano Taddeo³, Qingyu Cheng², Laleh Khodadadi², Gerd Burmester² and Falk Hiepe², ¹Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, ²Charité University Medicine, Department of Medicine/Rheumatology and Clinical Immunology and German Rheumatism Research Centre Berlin (DRFZ), Germany, Berlin, Germany, ³Deutsches Rheumaforschungszentrum, Berlin, Germany
Background/Purpose: B cells are playing a major role in granulomatosis with polyangiitis (GPA, formarly known as Wegener’s disease). This is reflected by the presence of…

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