Abstracts tagged "B cells and SLE"

Abstract Number: 12 • 2018 ACR/ARHP Annual Meeting
Protein Phosphatase 2A, a Serine/Threonine Phosphatase, Is Essential for Optimal B Cell Function
Esra Meidan¹, Hao Li², Christina Ioannidis³, Wenliang Pan³, Noe Rodriguez Rodriguez⁴, Jose Crispin⁴, Sokratis Apostolidis⁵, John Manis⁶, Amir Sharabi⁷, Maria G. Tsokos³ and George C Tsokos⁸, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico, ⁵Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Boston Children's Hospital, Boston, MA, ⁷Department of Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ⁸Division of Rheumatology, Department of Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, Boston, MA
Background/Purpose: Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase ubiquitously expressed in eukaryotic cells. PP2A levels and activity are increased in T cells from patients…
Abstract Number: 2644 • 2017 ACR/ARHP Annual Meeting
Increased Toll-like Receptor 7 Expression Promotes B Cell Abnormalities and Skewing of Cytokine and Autoantibody Profiles in SLE Patients
Ting Wang^1,2, John Marken², Van Tran², Mengtao Li³, Karen Cerosaletti⁴, Keith B. Elkon², Xiaofeng Zeng⁵ and Natalia V. Giltiay², ¹Department of Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, WA, China, ²Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ³Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China, ⁴Translational Research Program Benaroya Research Institute at Virginia Mason, Seattle, WA, USA, Seattle, WA, ⁵Rheumatology, Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Toll-like receptor 7 (TLR7) is implicated in the production of type I IFNs and the activation of B cells in systemic lupus erythematosus (SLE).…
Abstract Number: 35 • 2013 ACR/ARHP Annual Meeting
Defective Regulatory Function Of Granzyme B-Producing B Cells In Patients With Systemic Lupus Erythematosus
Naoko Ueki, Hiroaki Niiro, Shun-ichiro Ota, Hirofumi Tsuzuki, Siamak Jabbarzadeh-Tabrizi, Yuri Hirosaki, Kumiko Noda, Naoyasu Ueda, Atsushi Tanaka, Masahiro Ayano, Sho Ueda, Satomi Hisamoto, Daisuke Oryoji, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroshi Tsukamoto, Takahiko Horiuchi and Koichi Akashi, Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: The efficacy of B-cell depletion therapy highlights a pathogenic role of B cells in autoimmune diseases. In certain conditions, elimination of B cells can…

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