Abstracts tagged "B cells and Sjogren’s syndrome"

Abstract Number: 1078 • 2016 ACR/ARHP Annual Meeting
Elevated Proportion of CD38highIgD+ b Cells in Peripheral Blood Is Related to Disease Activity in Patients with Primary SjöGren’s Syndrome
Eriko Ishioka¹, Keiko Yoshimoto², Katsuya Suzuki³, Ayumi Nishikawa², Hidekata Yasuoka⁴, Kunihiro Yamaoka⁵ and Tsutomu Takeuchi⁴, ¹Connective tissue disease, National Tokyo Medical Center, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ⁴Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan, ⁵Keio University, Tokyo, Japan
Background/Purpose: Primary Sjögren’s syndrome (pSS) is well recognized as an autoimmune disease accompanied by hypergammaglobulinemia and production of autoantibodies such as anti-Ro/SSA and anti-La/SSB antibodies.…
Abstract Number: 2666 • 2016 ACR/ARHP Annual Meeting
Therapeutic Efficacy of Iguratimod in Patients with Primary Sjogren’s Syndrome
Lingshu Zhang¹, Wei Jiang², Cong-Qiu Chu³, Yi Liu⁴ and Yi Liu, ¹Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, China, ²The Ninth People's Hospital of Chongqing, Chongqing, China, ³Rheumatology, Oregon Health & Science University, Portland, OR, ⁴Department of Rheumatology and Immunology, West China Hospital of Sichuan University, Chengdu, China
Background/Purpose: Iguratimod (IGU), a methanesulfonanilide, has been used as a novel disease-modifying antirheumatic drug for treatment of rheumatoid arthritis in Japan and China. IGU displayed significantly inhibition…
Abstract Number: 1125 • 2015 ACR/ARHP Annual Meeting
Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren’s Syndrome
William Murray-Brown¹, Emanuela Carlotti¹, Anwar Tappuni², Nurhan Sutcliffe³, Costantino Pitzalis⁴ and Michele Bombardieri⁵, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ²Oral Medicine Department, Institute of Dentistry, QMUL, London, United Kingdom, ³Rheumatology, Barts Health NHS Trust, London, United Kingdom, ⁴Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, ⁵Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom
Background/Purpose: B cells play a central role in Sjogren’s syndrome (SS) pathogenesis whereby autoreactive B-cells populate ectopic germinal centres (eGC) in SS-salivary glands (SG) and…
Abstract Number: 1495 • 2013 ACR/ARHP Annual Meeting
Lesional Intereukin-21 Expression Correlates With Functional Germinal Center Formation and T Follicular Helper Cell Infiltration In The Salivary Glands Of Sjogren’s Syndrome
William Murray-Brown¹, Cristina Croia¹, Nurhan Sutcliffe², Anwar Tappuni³, Costantino Pitzalis¹ and Michele Bombardieri⁴, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ²Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ³Department of Oral Medicine,, Institute of Dentistry, Queen Mary University of London, London, United Kingdom, ⁴Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom
Background/Purpose: IL-21 is a pro-inflammatory cytokine that plays a key role in the activation and differentiation of B cells. B cells infiltrate the salivary glands…
Abstract Number: 1772 • 2012 ACR/ARHP Annual Meeting
Expansion of Autoreactive Unresponsive CD21^-/Low B Cells in Sjögren’s Syndrome Associated Lymphoproliferation
David Saadoun¹, Benjamin Terrier², J. Bannock Sr.³, T. Vazquez Sr.⁴, C. Massad Sr.³, Florence Joly Sr.⁵, Michelle Rosenzwajg Sr.⁶, Damien Sene Sr.⁷, Philippe Benech Sr.⁵, David Klatzmann Sr.⁶, Eric Meffre Sr.³ and Patrice Cacoub Sr.⁸, ¹Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ²Internal Medicine, Cochin University Hospital, Paris, France, ³Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ⁴I3 “Immunology, Immunopathology, Immunotherapy” laboratory, CNRS UMR 7211 and INSERM U959, Paris, France, ⁵Prediguard, Marseille, France, ⁶Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Paris, France, ⁷Department of Internal Medicine; 5 P3S post-genomic plateform, Groupe Hospitalier Pitié-Salpétrière, Université Pierre et Marie Curie, Paris, France, ⁸Department of Internal Medicine 2., CHU Pitié-Salpêtrière, Paris, France
Background/Purpose: Primary Sjögren's syndrome (pSS) is the autoimmune disease associated with the higher risk of developing non-Hodgkin lymphoma. Objective: To determine the nature of B…
Abstract Number: 512 • 2012 ACR/ARHP Annual Meeting
Memory B Cell Phenotypic and Gene Expression Profiling in Primary Sjogren’s Syndrome: Implications for Disease Diagnosis
Mustimbo E. P. Roberts¹, Craig Maguire¹, Alex Rosenberg², Andreea Coca³, Jennifer H. Anolik⁴ and Inaki Sanz⁵, ¹University of Rochester School of Medicine and Dentistry, Rochester, NY, ²University of Rochester, Rochester, NY, ³Univ of Rochester, Rochester, NY, ⁴Medicine- Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵Medicine/Rheumatology, Rochester, Rochester, NY
Background/Purpose: A paucity of known causative mechanisms in primary Sjögren’s Syndrome (pSS) contributes to inadequate classification criteria. However, known memory-phenotype B cell aberrations could enrich…
Abstract Number: 513 • 2012 ACR/ARHP Annual Meeting
Regulatory B Cells in Primary Sjögren’s Syndrome
Gabriela Hernandez-Molina¹, Janette Furusawa-Carballeda¹, Guadalupe Lima², Yahaira Rivera¹ and Luis Llorente³, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, ³Immunology and Rheumatology Department, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico
Background/Purpose: B cells have traditionally been considered as positive regulators of humoral immune response, however their negative regulatory role has recently being recognized. Objective. To…

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