ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstracts tagged "B cells and rheumatoid arthritis (RA)"

  • Abstract Number: 78 • 2018 ACR/ARHP Annual Meeting

    Decreased B Cell Ataxia-Telangiectasia Mutated Expression and Receptor Diversity Identify a Subset of Rheumatoid Arthritis Patients with Increased Joint Erosion Prevalence

    Kofi Mensah1, Jean-Nicolas Schickel2, Isabel Isnardi2 and Eric Meffre2, 1Section of Rheumatology, Yale University School of Medicine, New Haven, CT, 2Department of Immunobiology, Yale University School of Medicine, New Haven, CT

    Background/Purpose: A skewed B cell receptor (BCR) repertoire was observed in some RA patients. In these patients, BCR κ light chains contain a higher percentage…
  • Abstract Number: 835 • 2018 ACR/ARHP Annual Meeting

    Identifying Individuals with High Risk for Imminent Onset of Rheumatoid Arthritis

    Anne Musters1, Marian van Beers-Tas2, Marieke E. Doorenspleet1, Paul L. Klarenbeek3, Barbera C.D. van Schaik4, Antoine H.C. van Kampen4, Frank Baas5, Dirkjan van Schaardenburg6 and Niek de Vries1, 1Amsterdam Rheumatology and immunology Center | Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rheumatology and Immunology Center | Reade, Amsterdam, Netherlands, 3Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 4Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Genome Analysis, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6Amsterdam Rheumatology and immunology Center, Reade, Amsterdam, Netherlands

    Background/Purpose: A phase characterized by the presence of specific autoantibodies and arthralgias in the absence of clinically evident synovial inflammation often precedes the onset of…
  • Abstract Number: 836 • 2017 ACR/ARHP Annual Meeting

    B Cell Receptor Sequencing of Anti-Citrullinated Protein Antibody Expressing B Cells Indicates a Selective Advantage for the Introduction of N-Glycosylation Sites during Somatic Hypermutation

    Rochelle D. Vergroesen1, Linda Slot1, Lise Hafkenscheid1, Marvyn T. Koning2, Ellen I.H. van der Voort3, Christine A. Grooff1, George Zervakis2, Tom W.J. Huizinga1, Theo Rispens4, Hendrik Veelken2, Rene E.M. Toes1 and Hans U. Scherer3, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Hematology, Leiden University Medical Center, Leiden, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Immunopathology, Sanquin Research, Amsterdam, Netherlands

    Background/Purpose: The vast majority (>90%) of anti-citrullinated protein antibodies (ACPA) of the IgG isotype in serum and synovial fluid of patients with rheumatoid arthritis carry…
  • Abstract Number: 2111 • 2016 ACR/ARHP Annual Meeting

    Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B-Cell Clones

    Kristine Germar1,2, Mark Kwakkenbos3, Sabrina Pollastro1,2, Nathalie van Uden1,2,4, Priscilla Kerkman5, Ellen I.H. van der Voort6, Evan Reed7, Karin Lundberg7, Niek de Vries1,8, Lars Klareskog7, Hans U. Scherer5, René E.M. Toes5, Arjen Bakker3, Hergen Spits3,9,10 and Dominique Baeten1,2,10, 1Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rheumatology and immunology Center, Amsterdam, Netherlands, 3AIMM Therapeutics, Amsterdam, Netherlands, 4Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 7Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 8Clinical Immunology and Rheumatology F4-105, Amsterdam Rheumatology and immunology Center, location AMC, Amsterdam, Netherlands, 9Department of Cell Biology and Histology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 10These authors contributed equally to this work, Amsterdam, Netherlands

    Background/Purpose:  Rheumatoid arthritis (RA) is the most frequent form of autoimmune arthritis with a prevalence of almost 1% worldwide. Anti-citrullinated protein antibodies (ACPA) are the…
  • Abstract Number: 2408 • 2013 ACR/ARHP Annual Meeting

    Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models

    Yvonne NW Kam1, Andrew Filer2, Christopher D. Buckley3, Costantino Pitzalis4 and Michele Bombardieri5, 1William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, QMUL, London, United Kingdom, 2Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, 3Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, 4Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, 5Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by the formation of synovial niches of autoreactive B cells which are favored by the autocrine production of B…
  • Abstract Number: 1276 • 2012 ACR/ARHP Annual Meeting

    Changes in B Cell Populations and Serum Immunoglobulins and Their Relationship to Infections in a One Year, Uncontrolled Open Label Study of Tabalumab

    Maria W. Greenwald1, Melissa Veenhuizen2, Wendy Komocsar3, Rebecca Jones-Taha4, Chin H. Lee3 and Pierre-Yves Berclaz3, 1Desert Medical Advances, Palm Desert, CA, 2Eli Lilly and Company, Indianapolis, IN, 3Eli Lilly & Company, Indianapolis, IN, 4PharmaNet/i3, Blue Bell, PA

    Background/Purpose: B cell activating factor (BAFF) is an important modulator of B cell development and proliferation and is secreted by neutrophils, monocytes, macrophages and dendritic…
  • Abstract Number: 2667 • 2012 ACR/ARHP Annual Meeting

    Activated Memory B Cell Compartment in Rheumatoid Arthritis: Impact of B Cell Depletion Therapy

    Diana G. Adlowitz1, Jennifer Hossler1, Jamie Biear2, Christopher A. Cistrone1, Teresa Owen1, Wensheng Wang1, Arumugam Palanichamy1, Ignacio Sanz3 and Jennifer H. Anolik1, 1Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, 2Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 3Allergy, Immunology and Rheumatology, Emory University School of Medicine, Atlanta, GA

    Background/Purpose: B cells are critical players in the orchestration of properly regulated immune responses.  This is achieved through the finely regulated participation of multiple B…
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
This site uses cookies: Find out more.