Abstract Number: 78 • 2018 ACR/ARHP Annual Meeting
Decreased B Cell Ataxia-Telangiectasia Mutated Expression and Receptor Diversity Identify a Subset of Rheumatoid Arthritis Patients with Increased Joint Erosion Prevalence
Background/Purpose: A skewed B cell receptor (BCR) repertoire was observed in some RA patients. In these patients, BCR κ light chains contain a higher percentage…Abstract Number: 835 • 2018 ACR/ARHP Annual Meeting
Identifying Individuals with High Risk for Imminent Onset of Rheumatoid Arthritis
Background/Purpose: A phase characterized by the presence of specific autoantibodies and arthralgias in the absence of clinically evident synovial inflammation often precedes the onset of…Abstract Number: 836 • 2017 ACR/ARHP Annual Meeting
B Cell Receptor Sequencing of Anti-Citrullinated Protein Antibody Expressing B Cells Indicates a Selective Advantage for the Introduction of N-Glycosylation Sites during Somatic Hypermutation
Background/Purpose: The vast majority (>90%) of anti-citrullinated protein antibodies (ACPA) of the IgG isotype in serum and synovial fluid of patients with rheumatoid arthritis carry…Abstract Number: 2111 • 2016 ACR/ARHP Annual Meeting
Generation and Characterization of Anti-Citrullinated Protein Antibody-Producing B-Cell Clones
Background/Purpose: Rheumatoid arthritis (RA) is the most frequent form of autoimmune arthritis with a prevalence of almost 1% worldwide. Anti-citrullinated protein antibodies (ACPA) are the…Abstract Number: 2408 • 2013 ACR/ARHP Annual Meeting
Secretory Leukocyte Protease Inhibitor Released By Rheumatoid Synovial Fibroblasts Exerts a Negative Control Of BAFF-Dependent B Cell Activation In Vitro and In Vivo In The Collagen-Induced and Chimeric RA/SCID Arthritis Models
Background/Purpose: Rheumatoid arthritis (RA) is characterized by the formation of synovial niches of autoreactive B cells which are favored by the autocrine production of B…Abstract Number: 1276 • 2012 ACR/ARHP Annual Meeting
Changes in B Cell Populations and Serum Immunoglobulins and Their Relationship to Infections in a One Year, Uncontrolled Open Label Study of Tabalumab
Background/Purpose: B cell activating factor (BAFF) is an important modulator of B cell development and proliferation and is secreted by neutrophils, monocytes, macrophages and dendritic…Abstract Number: 2667 • 2012 ACR/ARHP Annual Meeting
Activated Memory B Cell Compartment in Rheumatoid Arthritis: Impact of B Cell Depletion Therapy
Background/Purpose: B cells are critical players in the orchestration of properly regulated immune responses. This is achieved through the finely regulated participation of multiple B…
ACR Meeting Abstracts