Abstract Number: 1949 • ACR/ARHP Annual Meeting 2014
Defective PTEN Regulation and Function Contributes to B Cell Hyper-Responsiveness in Systemic Lupus Erythematosus
Xiangni Wu1, Yanxia Ye2, Jingwen Niu1, Yang Li1, Xin Li1, Xin You3, Hua Chen1, Lidan Zhao1, Xiaofeng Zeng4, Fengchun Zhang1, Fulin Tang1, Wei He1, Xuetao Cao5, Xuan Zhang6 and Peter E. Lipsky7, 1Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 2Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 3Division of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 4Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 5School of Basic Medicine, Peking Union Medical College, and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China, 6Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 7NIH, Charlottesville, VA
Background/Purpose: PTEN regulates normal signaling through the B cell receptor (BCR). In systemic lupus erythematosus(SLE), enhanced BCR signaling contributes to increased B cell activity. We, therefore,…
ACR Meeting Abstracts