Abstracts tagged "B cells and lupus nephritis"

Abstract Number: 85 • 2019 ACR/ARP Annual Meeting
Selective Inhibition of the Immunoproteasome with KZR-616 Blocks Multiple Cell Signaling Pathways, Plasma Cell Signatures and Myeloid Cell Associated Damage in the NZB/W Lupus Nephritis Model
Tony Muchamuel¹, Janet Anderl ¹, R Andrea Fan ¹, Henry Johnson ¹, Dustin McMinn ¹ and Christopher Kirk ¹, ¹Kezar Life Sciences, South San Francisco, CA
Background/Purpose: The immunoproteasome is a distinct class of proteasome found predominantly in immune effector cells and has been shown to play a distinct role in…

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Abstracts tagged "B cells and lupus nephritis"

Selective Inhibition of the Immunoproteasome with KZR-616 Blocks Multiple Cell Signaling Pathways, Plasma Cell Signatures and Myeloid Cell Associated Damage in the NZB/W Lupus Nephritis Model