Abstracts tagged "B cells and immunoglobulin (IG)"

Abstract Number: 83 • 2019 ACR/ARP Annual Meeting
Dysfunction of TRIM21 Promotes Aberrant Plasmablast Differentiation in Systemic Lupus Erythematosus Due to the Reduction of TRIM21-mediated Ubiquitylation of IRF5
Yosuke Kunishita¹, Ryusuke Yoshimi ¹, Reikou Kamiyama ¹, Daiga Kishimoto ¹, Koji Yoshida ¹, Eijin Hashimoto ¹, Yumiko Sugiyama ², Takaaki Komiya ¹, Natsuki Sakurai ¹, Yohei Kirino ³ and Hideaki Nakajima ³, ¹Department of Stem Cell and Immune Regulation / Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatic Diseases / Yokohama City University Medical Center, Yokohama, Japan, ³Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: TRIM21 is a member of the tripartite motif family proteins and is one of the autoantigens which react with anti-SS-A antibody (Ab) present in…

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Abstracts tagged "B cells and immunoglobulin (IG)"

Dysfunction of TRIM21 Promotes Aberrant Plasmablast Differentiation in Systemic Lupus Erythematosus Due to the Reduction of TRIM21-mediated Ubiquitylation of IRF5