Abstracts tagged "B cells and autoimmune diseases"

Abstract Number: 1122 • ACR/ARHP Annual Meeting 2015
B Cell Phenotypic Changes in Anti-Nuclear Antibody Positive Individuals Prior to the Onset of Systemic Autoimmune Rheumatic Disease
Joan Wither¹, Nan-Hua Chang¹, Babak Noamani², Dennisse Bonilla¹, Sindhu R. Johnson³, Larissa Lisnevskaia⁴, Earl Silverman⁵, Arthur Bookman¹ and Carolina Landolt-Marticorena¹, ¹University Health Network, Toronto, ON, Canada, ²Genetics and developmental biology, University Health Network, Toronto, ON, Canada, ³Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada, ⁴Lakeridge Health Services, Oshawa, ON, Canada, ⁵The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Patients with systemic autoimmune rheumatic diseases (SARD) often have a prolonged pre-clinical phase during which they are anti-nuclear antibody (ANA)+ but lack clinical symptoms. …
Abstract Number: 40 • ACR/ARHP Annual Meeting 2013
Preclinical Characterization Of a Humanized Antagonistic Anti-CD40 Mab
Kerry Ralph, Amy Nicoletti, Eunice Musvasva, Susan Cannan, Susan VanTongeren, Diann Blanset, Scott Brodeur, Jennifer Ahlberg, Hua Li, Steve Fogal, Sudha Desai, Kathy O'Shea, Rachel Kroe-Barrett, Gerald Nabozny, Helen Wu, Gale Hansen, Keith Canada, Sanjaya Singh, Meera Ramanujam and Christine Grimaldi, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: CD40-CD40L interactions play a central role in T-B cell costimulation. Targeting this pathway has generated great interest; however early attempts to target CD40L failed…