Abstracts tagged "B cell tolerance"

Abstract Number: 1117 • 2015 ACR/ARHP Annual Meeting
The B Cell Survival Cytokine BAFF Promotes Systemic Lupus Erythematosus Via Activation of TACI, Not BAFF Receptor
Holly Jacobs¹, Christopher Thouvenel¹, Tanvi Arkatkar¹, Nicole Scharping¹, David Rawlings² and Shaun Jackson¹, ¹Seattle Children's Research Institute, Seattle, WA, ²Pediatrics/Immunology, Washington, Seattle, WA
Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by polyclonal B cell activation and production of class-switched antinuclear antibodies (ANA). Transgenic mice…
Abstract Number: 1121 • 2015 ACR/ARHP Annual Meeting
Breach of B Cell Anergy in New Zealand Black Congenic Mice
Kieran Manion^1,2, Yuriy Baglaenko^1,2, Nan-Hua Chang³ and Joan Wither³, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ³University Health Network, Toronto, ON, Canada
Background/Purpose: Anti-DNA B cells are a primary cause of pathology in individuals with systemic lupus erythematosus (SLE), producing autoantibodies that deposit in diverse tissues and…
Abstract Number: 2793 • 2015 ACR/ARHP Annual Meeting
IL35 Serum Level Is Decreased in Patients with Primary Sjogren Syndrome, Essentially in Patients with the More Active Disease Data from the French Prospective Assess Cohort
Olivier Fogel¹, Raphaèle Seror², Gaetane Nocturne³, Elodie Rivière⁴, Saida Boudaoud⁵, Jacques Gottenberg⁶, Véronique Le Guern⁷, Xavier Mariette⁸, Jean-Jacques Dubost⁹ and Corinne Miceli-Richard¹⁰, ¹INSERM U1012, Paris Sud University, Le Kremlin Bicêtre, France, ²Rheumatology, AP-HP Bicêtre Hospital / Paris-Sud University, Le Kremlin-Bicêtre, France, ³INSERM U1012, Université Paris Sud, Le Kremlin Bicêtre, France, ⁴Unité INSERM 1184 Université Paris Sud, le Kremlin Bicetre, France, ⁵INSERM U1012 - Université Paris XI, Le Kremlin Bicêtre, France, ⁶Hautepierre, Strasbourg, France, ⁷National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ⁹Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ¹⁰Rheumatology, Hôpitaux Paris Sud & INSERM U1184, Le Kremlin Bicêtre, France
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is an autoimmune disease mediated by B-cells as evidenced by the occurrence of non-Hodgkin lymphoma and increased B-cell markers in…
Abstract Number: 3156 • 2015 ACR/ARHP Annual Meeting
IL17 Promotes Development of Autoreactive Early Stage B Cells in Distinct Regions of the Spleen Follicle
Jennie Hamilton¹, Qi Wu², PingAr Yang³, Jun Li⁴, Yanna Ding¹, Bao Luo⁵, John Mountz⁶ and Hui-Chen Hsu², ¹University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The early stage transitional B cell has been shown to be the key peripheral B-cell tolerance control point defect in SLE patients. Anti-RNP Abs can…
Abstract Number: 2869 • 2014 ACR/ARHP Annual Meeting
TLR7 Influences Autoreactive B Cell Selection in the Germinal Center
Weiqing Huang¹, Megan Woods¹, Alexis Boneparth², Ramalingam Bethunaickan¹, Ranjit Sahu¹ and Anne Davidson¹, ¹Autoimmunity and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY, ²Pediatric Rheumatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ
Background/Purpose: TLR7 is required for the generation of anti-RNA antibodies and excess TLR7 confers a SLE-like phenotype in mice. Recent studies have shown that TLR7…
Abstract Number: 2871 • 2014 ACR/ARHP Annual Meeting
Break of Anergy in Human Autoreactive B Cells By T Helper Signals Restores B Cell Receptor Signaling Capacity and Is Dependent on Upregulation of CD45 Phosphatase Activity-a Possible Novel Mechanism of Breech of B Cell Tolerance in Rheumatic Diseases
Peter Szodoray¹, Stephanie M. Stanford², Nunzio Bottini² and Britt Nakken¹, ¹Institute of immunology, Rikshospitalet, Oslo University Hospital, Oslo, Norway, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA
Background/Purpose : We recently identified a human B cell population, which is naturally autoreactive and tolerized by functional anergy. This population was naïve, fully mature,…
Abstract Number: 656 • 2014 ACR/ARHP Annual Meeting
Breach of B Cell Tolerance in New Zealand Black Chromosome 1 Congenic Mice
Kieran Manion^1,2, Nan-Hua Chang³, Yuriy Baglaenko^1,2 and Joan Wither^1,3, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ³Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Mapping studies in the lupus-prone New Zealand Black (NZB) mouse strain identified an interval from 170.8-181 Mb on chromosome 1 sufficient to induce B…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].