Abstracts tagged "B cell tolerance and SLE"

Abstract Number: 816 • 2015 ACR/ARHP Annual Meeting
Incomplete Tolerance in Anergic B Cells in SLE: T Helper Signals Restore B Cell Receptor Signaling in Autoreactive Anergic B Cells By Upregulating CD45 Phosphatase Activity
Peter Szodoray¹, Stephanie M. Stanford², Oyvind Molberg³, Nunzio Bottini² and Britt Nakken¹, ¹Institute of immunology, Rikshospitalet, Oslo University Hospital, Oslo, Norway, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Department of Rheumatology, Rikshospitalet, Oslo University Hospital, Oslo, Norway
Background/Purpose: We recently identified a human B cell population, which is naturally autoreactive and tolerized by functional anergy. This population was naïve, fully mature, negative…

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Abstracts tagged "B cell tolerance and SLE"

Incomplete Tolerance in Anergic B Cells in SLE: T Helper Signals Restore B Cell Receptor Signaling in Autoreactive Anergic B Cells By Upregulating CD45 Phosphatase Activity