Abstracts tagged "B cell tolerance and autoimmune diseases"

Abstract Number: 919 • 2016 ACR/ARHP Annual Meeting
IL-17 Receptor a Signaling Impedes NF-ĸB p50/p50 Repressor and Subverts B-Cell Anergy in BXD2 Mice
Jennie Hamilton¹, Qi Wu², PingAr Yang³, Bao Luo⁴, Woongjai Won⁵, Shanrun Liu⁶, Jun Li⁷, Hui-Chen Hsu² and John D. Mountz^8,9, ¹Medicine/Division of Clinical Immunology and Rhematology, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL, ⁹Department of Medicine, University of Alabama at Birmingham, birmingham, AL
Background/Purpose: In autoimmune prone BXD2 mice, abnormally upregulated IL-17 acts through NF-ĸB p65 role to promote the spontaneous germinal center response and autoantibody production. Recently,…

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