B cell targeting and rheumatoid arthritis (RA) Archives

Abstract Number: 997 • ACR/ARHP Annual Meeting 2014
Explore Translational Pharmacokinetics/Pharmacodynamics Response/Efficacy Relationship of a Novel Bruton’s Tyrosine Kinase Inhibitor in Rat Collagen-Induced Arthritis Model
Jie Zhang-Hoover¹, Erica Leccese¹, Kalyan Chakravarthy², Ian Knemeyer², Jos Lommerse², Marianne Spatz², Francois Gervais³, Raquel Sevilla⁴, Jian Liu⁵, Ronald Kim⁵, Sachin Lohani⁵, Kevin Matthew Maloney⁵, Joseph Kozlowski⁵ and Alexandra Hicks², ¹Pharmacology, Merck Research Laboratories, Boston, MA, ²Merck Research Laboratories, Boston, MA, ³Cell Pathways and Proteins, Merck & Co., Boston, MA, ⁴Imaging Group, Merck Research Laboratories, Boston, MA, ⁵Merck Research Laboratories, Rahway, NJ
Background/Purpose: Abnormal B cell activation is an essential part of autoimmune inflammation. B cell depletion is proven to be an efficacious treatment in patients as…

Abstracts tagged "B cell targeting and rheumatoid arthritis (RA)"