ACR Meeting Abstracts

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Abstracts tagged "B cell targeting and Macrophage"

  • Abstract Number: 2413 • 2019 ACR/ARP Annual Meeting

    LOU064: A Highly Selective and Potent Covalent Oral BTK Inhibitor with Promising Pharmacodynamic Efficacy on B Cells for Sjoegren’s Syndrome

    Bruno Cenni1, Peter End 1, Maciej Cabanski 1, Annamaria Jakab 1, Enrico Funhoff 1, Magdalena Kistowska 1, Arvind Kinhikar 2, Alessio Maiolica 1, Masaru Hirano 3, Barbara Nuesslein-Hildesheim 1, Amanda Littlewood-Evans 1, Daniela Angst 1, Robert Pulz 4 and Martin Kaul 1, 1Novartis Institutes for BioMedical Research, Basel, Switzerland, 2Novartis Institutes for BioMedical Research, Cambridge, MA, 3Novartis Institutes for BioMedical Research, Tokyo, Japan, 4Novartis Institues for BioMedical Research, Basel, Switzerland

    Background/Purpose: Bruton’s Tyrosine Kinase (BTK) is a cytoplasmic tyrosine kinase selectively expressed in B cells, macrophages, mast cells and basophils. The essential role of BTK…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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