ACR Meeting Abstracts

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Abstracts tagged "B cell targeting and BAFF"

  • Abstract Number: 1076 • 2016 ACR/ARHP Annual Meeting

    BAFF Receptor Antagonists Suppress Differentiation of B Cells in Vitro and Are Drug Candidates for Primary SjöGren’s Syndrome

    Keiko Yoshimoto1, Noriyasu Seki2, Katsuya Suzuki3, Kunio Sugahara4 and Tsutomu Takeuchi3, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 23) Research Unit/Frontier Therapeutic Sciences, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 3Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, 4Department I, Immunology, Pharmacology Research laboratories I, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan

    Background/Purpose:  We have reported that soluble BAFF (sBAFF) robustly increases IL-6 production in vitro by peripheral monocytes of patients with primary Sjögren’s syndrome (pSS) as…
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