Abstracts tagged "B cell targeting and BAFF"

Abstract Number: 1076 • 2016 ACR/ARHP Annual Meeting
BAFF Receptor Antagonists Suppress Differentiation of B Cells in Vitro and Are Drug Candidates for Primary SjöGren’s Syndrome
Keiko Yoshimoto¹, Noriyasu Seki², Katsuya Suzuki³, Kunio Sugahara⁴ and Tsutomu Takeuchi³, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²3) Research Unit/Frontier Therapeutic Sciences, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, ³Keio University School of Medcine, Division of Rheumatology, Department of Internal Medicine, Tokyo, Japan, ⁴Department I, Immunology, Pharmacology Research laboratories I, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
Background/Purpose: We have reported that soluble BAFF (sBAFF) robustly increases IL-6 production in vitro by peripheral monocytes of patients with primary Sjögren’s syndrome (pSS) as…