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Abstracts tagged "B cell targeting and B cells"

  • Abstract Number: 1952 • ACR/ARHP Annual Meeting 2016

    Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

    Judith Land1, Lucas L. Lintermans1, Coen A. Stegeman2, Ernesto J. Muñoz-Elías3, Peter Heeringa4, Abraham Rutgers1 and Wayel H. Abdulahad1, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Kineta Inc, Seattle, WA, 4Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Granulomatosis with polyangiitis (GPA) patients are often treated with immunesuppressives or B cell depleting therapy. While B cells are involved in GPA pathogenesis as…

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