Abstracts tagged "B cell memory and Sjogren’s syndrome"

Abstract Number: 1077 • 2016 ACR/ARHP Annual Meeting
Increased Expression of B-Cell Lipid Rafts in Patients with Primary Sjogren’s Syndrome Correlated Positively with Disease Activity Score, Suggesting a B Cell Activated State Potentially Relevant for the Disease Pathogenesis and Response to Biologic Therapies
Nicolyn Thompson¹, Akash Gandhi², Rebecca Radmore², Su Cho², David A. Isenberg³, Elizabeth Jury⁴ and Coziana Ciurtin⁵, ¹Inflammation, University College London, London, United Kingdom, ²Medical School, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom, ⁵Rheumatology Department, University College London, London, United Kingdom
Background/Purpose: Recent research indicates that lipid rafts play an important role during B-cell activation and could be defective in patients with primary Sjӧgren’s syndrome (pSS).…

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