Abstracts tagged "B cell"

Abstract Number: 884 • 2019 ACR/ARP Annual Meeting
Interferon-Alpha Disrupts Multiple B Cell Tolerance Mechanisms in 3H9 Mice
Dario Ferri ¹, Yuriy Baglaenko ², Kieran Manion ³, Carolina Munoz-Grajales ⁴ and Joan Wither⁵, ¹University Health Network, Toronto, ON, Canada, ²Brigham Woman's Hospital, Boston, ³Krembil Research Institute, Toronto, ON, Canada, ⁴University Health Network, Toronto, Canada, ⁵University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Interferon-alpha (IFNα) is elevated in Systemic Lupus Erythematosus (SLE) and is thought to play a central role in its pathogenesis. Amongst IFNα’s many effects…
Abstract Number: 968 • 2019 ACR/ARP Annual Meeting
Circulating PR3-Specific B Cells in Patients with Active ANCA-Associated Vasculitis
Alvise Berti¹, Sophie Hillion ², Amber Hummel ¹, Eva Carmona ¹, Tobias Peikert ¹, Carol Langford ³, Peter Merkel ⁴, Paul Monach ⁵, Philip Seo ⁶, Robert Spiera ⁷, E William St. Clair ⁸, Fernando Fervenza ¹, Kristina Harris ⁹, John Stone ¹⁰, Jacques-Olivier Pers ¹¹, Peter Heeringa ¹², Wayel Abdulahad ¹³, Ulrich Specks ¹⁴ and Divi Cornec ¹¹, ¹Mayo Clinic, Rochester, MN, ²Université de Bretagne Occidentale, Brest, Bretagne, France, ³Cleveland Clinic, Cleveland, OH, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Brigham and Women's Hospital, Boston, MA, ⁶Johns Hopkins Medicine, Baltimore, MD, ⁷Hospital for Special Surgery, New York, NY, ⁸Duke, Raleigh, ⁹Immune Tolerance Network, Bethesda, ¹⁰Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ¹¹Universite de Bretagne Occidentale, Brest, Bretagne, France, ¹²Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, ¹³Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, ¹⁴Mayo Clinic College of Medicine, Rochester, MN
Background/Purpose: We previously developed a method to recognize proteinase 3 (PR3)-specific B cells by flow cytometry. We reported that, in a small number of subjects,…

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