Abstracts tagged "axial spondyloarthritis"

Abstract Number: 580 • 2019 ACR/ARP Annual Meeting
Association of Comorbidities with Disease Activity and Functional Impairment in Axial Spondyloarthritis: Results from a Nationwide Population-Based Study
Imke Redeker¹, Johanna Callhoff ², Falk Hoffmann ³, Hildrun Haibel ⁴, Joachim Sieper ⁴, Angela Zink ⁵ and Denis Poddubnyy ⁶, ¹Charité – Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³Carl von Ossietzky University, Oldenburg, Germany, ⁴Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ⁵German Rheumatism Research Centre and Charité University medicine, Berlin, Germany, ⁶Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany
Background/Purpose: Data on the prevalence of comorbidities and their association with disease activity and functional impairment in axial spondyloarthritis (axSpA) are scarce. The aim of…
Abstract Number: 615 • 2019 ACR/ARP Annual Meeting
Effects of NSAIDs and TNF Inhibitors on Cardiovascular Events in Ankylosing Spondylitis: A Systematic Review and Meta-Analysis
Paras Karmacharya¹, Ravi Shahukhal ², Cynthia Crowson ³, M.Hassan Murad ⁴, Pragya shrestha ⁵, Delamo Bekele ⁶, Kerry Wright ⁴, John Davis ⁴ and Maureen Dubreuil ⁷, ¹Reading Hospital, Mayo Clinic, Rochester, ²Lakes Regional General Hospital, Laconia, NH, ³Mayo Clinic Rochester, Rochester, ⁴Mayo Clinic, Rochester, MN, ⁵Mayo Clinic. Rochester, MN, Rochester, MN, ⁶Mayo Clinic Rochester, Rochester, MN, ⁷Boston University School of Medicine, Boston, MA
Background/Purpose: Most studies show a significantly higher risk of myocardial infarction [MI] (odds ratio [OR] = 1.60) and stroke (OR = 1.50) in ankylosing spondylitis (AS)…
Abstract Number: 938 • 2019 ACR/ARP Annual Meeting
TNF Inhibitors Reduce Spinal Radiographic Progression in Axial Spondyloarthritis by Mechanisms Associated with but Also Independent of Disease Activity
Alexandre Sepriano¹, Sofia Ramiro ², Stephanie Wichuk ³, Praveena Chiowchanwisawakit ⁴, Terrie MacCosham ³, Joel Paschke ⁵, Désirée van der Heijde ¹, Robert B.M. Landewé ⁶ and Walter Maksymowych ⁷, ¹Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center and Zuyderland Medical Centre, Leiden, Netherlands, ³University of Alberta, Edmonton, Canada, ⁴Mahidol University, Bangkok, Thailand, ⁵CARE Arthritis, Edmonton, Canada, ⁶Amsterdam University Medical Center, Amsterdam, Netherlands, ⁷University of Alberta and CARE Arthritis, Edmonton, Canada
Background/Purpose: Recent observational data suggest that TNFi reduce spinal radiographic progression in radiographic axial spondyloarthritis (r-axSpA) mostly by inhibiting disease activity1. Yet, resolution on the…
Abstract Number: 1507 • 2019 ACR/ARP Annual Meeting
Certolizumab Pegol Improves Work and Household Productivity and Social Participation over 1 Year of Treatment in Patients with Non-Radiographic Axial Spondyloarthritis
Atul Deodhar¹, Lianne Gensler ², Jonathan Kay ³, Walter P. Maksymowych ⁴, Nigil Haroon ⁵, Robert B.M. Landewé ⁶, Martin Rudwaleit ⁷, Stephen Hall ⁸, Lars Bauer ⁹, Bengt Hoepken ⁹, Natasha de Peyrecave ¹⁰, Thomas Kumke ¹¹ and Désirée van der Heijde ¹², ¹Oregon Health & Science University, Portland, OR, ²University San Francisco California, San Francisco, CA, ³UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ⁴University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ⁵Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada, ⁶Amsterdam University Medical Center, Amsterdam, Netherlands, ⁷Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ⁸Monash University and Emeritus Research, Melbourne, Australia, ⁹UCB Pharma, Monheim am Rhein, Germany, ¹⁰UCB Pharma, Slough, United Kingdom, ¹¹UCB Pharma, Monheim, Germany, ¹²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Patients (pts) with non-radiographic axial spondyloarthritis (nr-axSpA) report substantial impairment of productivity and daily activities due to the burden of their disease, similar to…
Abstract Number: 1854 • 2019 ACR/ARP Annual Meeting
The Utility of Fat Lesions in Close Relation to Other Structural MRI Lesions in the Sacroiliac Joints for Diagnosing Patients with Axial Spondyloarthritis
Sengül Seven¹, Mikkel Østergaard ², Lone Morsel-Carlsen ³, inge Juul Sørensen ¹, Birthe Bonde ⁴, Gorm Thamsborg ⁵, Jens Jørgen Lykkegaard ¹, Oliver Hendricks ⁶, Niklas Rye Jørgensen ⁷ and Susanne Juhl Pedersen ⁸, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, ²Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, ³Department of Radiology, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, ⁴The Birthe Bonde Clinic of Physioterapy, Copenhagen, Denmark, Glostrup, Denmark, ⁵Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark, ⁶Danish Hospital for Rheumatic Diseases, Sønderborg, Denmark, Sønderborg, Denmark, ⁷Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Denmark, Glostrup, Denmark, ⁸Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Hovedstaden, Denmark
Background/Purpose: Bone marrow edema on MRI of the sacroiliac joints (SIJ) plays an important role in the ASAS (Assessment of Spondyloarthritis International Society) classification criteria…
Abstract Number: 582 • 2019 ACR/ARP Annual Meeting
Rheumacheck – Spondyloarthritis: Comprehensive Fast-track Diagnosis Program. What Benefits Does It Offer in a Developing Country?
Einer Sanchez Prado¹, Alvaro Ruta ², Jessica Torres Chichande ², Santiago Ruta ³, Sebastian Magri ², Facundo Salvatori ² and Rodrigo Garcia Salinas ², ¹Hospital Italiano de La Plata, La Plata, ²Hospital Italiano de La Plata, La plata, Buenos Aires, Argentina, ³Rheumatology Department, Hospital San Martín de La Plata and Rheumatology Unit, Hospital Italiano de La Plata, Argentina., La Plata, Argentina
Background/Purpose: In our region, the lack of knowledge, timely referral and access to laboratory tests and images are the main causes in the diagnostic delay…
Abstract Number: 616 • 2019 ACR/ARP Annual Meeting
Association of Clinical and Radiographic Phenotype of Axial Spondyloarthritis and Skin Psoriasis: Results from the German Spondyloarthritis Inception Cohort
Mikhail Protopopov¹, Fabian Proft ², Joachim Sieper ², Hildrun Haibel ², Martin Rudwaleit ³ and Denis Poddubnyy ⁴, ¹Charité Universitätsmedizin Berlin, Germany, Berlin, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Germany, Berlin, Germany, ³Klinikum Bielefeld, Charité Berlin, Gent University, Bielefeld, Germany, ⁴Charité - Universitätsmedizin Berlin and German Rheumatism Research Centre, Berlin, Germany, Berlin, Germany
Background/Purpose: Psoriasis is a common feature of axial spondyloarthritis (axSpA) occuring in approximately 10% of patients with axSpA. It has been presumed that such an…
Abstract Number: 1006 • 2019 ACR/ARP Annual Meeting
Vaspin rs35262691 Is Associated with Atherosclerotic Disease in Axial Spondyloarthritis Patients
Fernanda Genre¹, Javier Rueda-Gotor ¹, Sara Remuzgo-Martinez ¹, Veronica Pulito-Cueto ¹, Alfonso Corrales ¹, Veronica Mijares ¹, Leticia Lera-Gomez ¹, Virginia Portilla ¹, Rosa Expósito ², Cristina Mata ², Iván Ferraz-Amaro ³, Vanesa Hernández-Hernández ³, Santos Castañeda ⁴, Esther Vicente-Rabaneda ⁵, Cristina Fernández-Carballido ⁶, M. Paz Martínez-Vidal ⁷, David Castro-Corredor ⁸, Joaquín Anino-Fernández ⁸, Juan Quevedo-Abeledo ⁹, Carlos Rodríguez-Lozano ⁹, Ricardo Blanco ¹⁰, María Luz García-Vivar ¹¹, Eva Galíndez-Agirregoikoa ¹¹, Javier Llorca ¹², Raquel López-Mejías ¹ and Miguel Angel González-Gay ¹³, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Rheumatology Division, Hospital Comarcal de Laredo, Laredo, Spain, Laredo, Spain, ³Rheumatology Division, Hospital Universitario de Canarias, Tenerife, Spain, Tenerife, Spain, ⁴Rheumatology Department, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain, Madrid, Spain, ⁵Rheumatology Department, Hospital Universitario La Princesa, Madrid, Spain, ⁶Rheumatology Division, Hospital Universitario San Juan de Alicante, Alicante, Spain, Alicante, Spain, ⁷Rheumatology Division, Hospital General Universitario de Alicante, Alicante, Spain, Alicante, Spain, ⁸Rheumatology Division, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, Ciudad Real, Spain, ⁹Rheumatology Division, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain, Las Palmas de Gran Canaria, Spain, ¹⁰Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, ¹¹Rheumatology Unit, Basurto University Hospital, Bilbao, Spain, Bilbao, Spain, ¹²School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, Santander, Spain, ¹³Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Background/Purpose: Vaspin is a novel adipokine with insulin-sensitizing functions that exerts anti-inflammatory actions1,2. It has been associated with cardiovascular (CV) disease, CV risk factors and…
Abstract Number: 1509 • 2019 ACR/ARP Annual Meeting
Impact of Age and Disease Duration on the Response to IL-17A Inhibitor (Secukinumab) Treatment in Ankylosing Spondylitis: Pooled Results from the Phase 3 MEASURE Studies
Atul Deodhar¹, Philip Mease ², Paula Machado ³, Xiangyi Meng ³, Vibeke Strand ⁴ and Marina Magrey ⁵, ¹Oregon Health & Science University, Portland, OR, ²Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, ³Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁴Division of Immunology/Rheumatology, Stanford University, Stanford, CA, ⁵Division of Rheumatology, The MetroHealth System and School of Medicine, Case Western Reserve University, Cleveland, OH
Background/Purpose: Ankylosing spondylitis (AS), a chronic inflammatory disease involving the sacroiliac joints and spine, is associated with pain, stiffness, disability, and reduced quality of life.1,2…
Abstract Number: 2212 • 2019 ACR/ARP Annual Meeting
Patients with Axial Spondyloarthritis Have Abnormal Microarchitecture Despite Normal Areal Bone Mineral Density and Trabecular Bone Score by DXA
Dalit Ashany¹, Susan Goodman ², Haley Tornberg ¹, Donald McMahon ³, Douglas Mintz ⁴, Linda Russell ⁵ and Emily Stein ¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ³Donald J.McMahon Statistical Consulting, South Nyack, NY, ⁴Hospital for Special Surgery, Division of Radiology and Imaging, New York, ⁵Hospital for Special Surgery, New York
Background/Purpose: Axial Spondyloarthritis (axSpA) is characterized by abnormal bone formation that produces syndesmophytes, while paradoxically, inflammation causes increased bone resorption and skeletal fragility. Detection of…
Abstract Number: 14 • 2019 ACR/ARP Annual Meeting
Sec16A Abnormalities Affect the Intracellular Trafficking of HLA-B27 in the Pathogenesis of Axial Spondyloarthritis
Ayantika Talukdar¹, Fanxing Zeng ², Zhenbo Zhang ¹ and Nigil Haroon ³, ¹University Health Network, Toronto, ON, Canada, ²University Health Network, Toronto, Canada, ³Toronto Western Hospital, Krembil Research Institute, University of Toronto, Toronto, ON, Canada
Background/Purpose: Axial Spondyloarthritis (AxSpA) is a chronic inflammatory arthritis, mainly affecting the axial skeleton. HLA-B27 confers the greatest genetic association in AxSpA. Exome sequencing in…
Abstract Number: 590 • 2019 ACR/ARP Annual Meeting
What Is the Impact of MRI on the Performance of the ASAS Classification Criteria in Patients Presenting with Undiagnosed Back Pain?
Walter P. Maksymowych¹, Raj Carmona ², Jonathan Chan ³, James Yeung ⁴, Sibel Zehra Aydin ⁵, Liam Martin ⁶, Ariel Masetto ⁷, Dianne Mosher ⁸, Olga Ziouzina ⁶, Stephanie Keeling ⁹, Sherry Rohekar ¹⁰, Rana Dadashova ¹¹, Joel Paschke ¹¹, Amanda Carapellucci ¹¹ and Robert Lambert ¹², ¹University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada, ²McMaster University, Hamilton, Canada, ³Artus Health Clinic, Vancouver, BC, Canada, ⁴Yeung Rheumatology, Vancouver, Canada, ⁵University of Ottawa Faculty of Medicine, Rheumatology,Ottawa Hospital Research Institute, 1967 Riverside Drive, Ottawa, ON, K1H 7W9, CANADA, Ottawa, Canada, ⁶University of Calgary, Calgary, Canada, ⁷Université de Sherbrooke, Sherbrooke, QC, Canada, ⁸University of Calgary, Calgary, AB, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Western University, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, Canada, ¹²University of Alberta, Edmonton, Canada
Background/Purpose: Classification criteria for axSpA comprise an imaging and a clinical arm, the former requiring radiographic or MRI evidence of sacroiliitis. Several cohorts have reported…
Abstract Number: 660 • 2018 ACR/ARHP Annual Meeting
Progression of Radiographic Sacroiliitis in Patients with Axial Spondyloarthritis from the Assessment of Spondyloarthritis International Society Cohort on Central Reading – Five-Year Data
Mikhail Protopopov¹, Fabian Proft¹, Alexandre Sepriano^2,3, Robert B.M. Landewé^4,5, Désirée van der Heijde², Joachim Sieper¹, Martin Rudwaleit^6,7 and Denis Poddubnyy^1,8, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal, ⁴Zuyderland Medical Center, Heerlen, Netherlands, ⁵Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam, Netherlands, ⁶Charité Universitätsmeidzin Berlin, Berlin, Germany, ⁷Rheumatology, Klinikum Bielefeld Rosenhöhe, Berlin, Germany, ⁸German Rheumatism Research Centre, Berlin, Germany
Background/Purpose: It is known that radiographic progression of sacroiliitis in axial spondyloarthritis (axSpA) is quite slow, with only few predictors of such progression identified. An…
Abstract Number: 1658 • 2018 ACR/ARHP Annual Meeting
Which Factors Influence the Diagnostic Delay in Patients with Axial Spondyloarthritis?
Imke Redeker¹, Johanna Callhoff¹, Falk Hoffmann², Hildrun Haibel³, Joachim Sieper⁴, Angela Zink⁵ and Denis Poddubnyy⁴, ¹Epidemiology Unit, German Rheumatism Research Centre, Berlin, Germany, ²Department of Health Services Research, Carl von Ossietzky University, Oldenburg, Germany, ³Charité Universitätmedizin Berlin, Berlin, Germany, ⁴Rheumatology, Charité Universitätsmeidzin Berlin, Berlin, Germany, ⁵Epidemiology Unit / Rheumatology and Clinical Immunology, German Rheumatism Research Centre (DRFZ) / Charité University Hospital, Berlin, Germany
Background/Purpose: The interval from symptom onset till diagnosis in axial spondyloarthritis (axSpA) was reported a decade ago to be between five and ten years. The…
Abstract Number: 661 • 2018 ACR/ARHP Annual Meeting
Bridging the Gap between Symptom Onset and Diagnosis in Axial Spondyloarthritis
Laura Passalent^1,2,3, Kala Sundararajan⁴, Anthony V. Perruccio⁵, Christopher Hawke^6,7, Nigil Haroon^8,9,10, Robert D Inman^3,11,12 and Y. Raja Rampersaud^5,6,13, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, Toronto, ON, Canada, ²Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, Toronto, ON, Canada, ³Arthritis Program, Krembil Research Institute, Toronto, ON, Canada, ⁴Orthopaedic Research Department, Toronto Western Hospital, Toronto, ON, Canada, ⁵Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁶Orthopaedics, Toronto Western Hospital, Toronto, ON, Canada, ⁷Department of Physical Therapy, University of Toronto, Toronto, ON, Canada, ⁸Arthrits Program, Krembil Research Institute, Toronto, ON, Canada, ⁹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ¹⁰Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, ¹¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ¹²Toronto Western Hospital, Toronto, ON, Canada, ¹³University of Toronto, Toronto, ON, Canada
Background/Purpose: Axial spondyloarthritis (axSpA) is diagnosed an average of 9 years after symptom onset (1), partly because inflammatory back pain (IBP) can be difficult…

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