Abstracts tagged "axial spondyloarthritis"

Abstract Number: 1581 • 2014 ACR/ARHP Annual Meeting
Inflammatory Back Pain in Psoriasis and Psoriatic Arthritis Is Suggestive of Undiagnosed Spondyloarthropathies
Majed Khraishi¹, Heather Jones^2,3 and Annette Szumski⁴, ¹Clinical Professor of Medicine (Rheumatology), Memorial University of Newfoundland, St. John's, NF, Canada, ²Inflammation & Immunology, Pfizer Inc., Collegeville, PA, ³Pfizer Inc., Collegeville, PA, ⁴Specialty Care, Pfizer Inc., Collegeville, PA
Background/Purpose: Patients with psoriasis (Ps) and/or psoriatic arthritis (PsA) may have clinical features suggestive of axial skeletal abnormalities and should be assessed for the presence…
Abstract Number: 855 • 2014 ACR/ARHP Annual Meeting
Active and Structural Lesions on MRI of the Sacroiliac Joints Predict Major Clinical Responses in Patients with Non-Radiographic Axial Spondyloarthritis Treated with Etanercept
Walter P. Maksymowych¹, S Wichuk¹, H Jones², A Szumski³, L Marshall⁴, J Bukowski⁵ and RG Lambert⁶, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Inflammation & Immunology, Pfizer Inc., Collegeville, PA, ³Specialty Care, Pfizer Inc., Collegeville, PA, ⁴Inflammation Immunology Disease Group, Pfizer Inc., Collegeville, PA, ⁵Pfizer Inc., Collegeville, PA, ⁶Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Previous studies evaluating predictors of major clinical response in patients with non-radiographic axial SpA (nr-axSpA) receiving treatment with anti-TNF agents have been limited by…
Abstract Number: 852 • 2014 ACR/ARHP Annual Meeting
Safety and Efficacy of Certolizumab Pegol over 96 Weeks in Patients with Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis
Joachim Sieper¹, Martin Rudwaleit², Désirée M. van der Heijde³, Walter P. Maksymowych⁴, Maxime Dougados⁵, Philip J. Mease⁶, Jürgen Braun⁷, Atul A. Deodhar⁸, Bengt Hoepken⁹, Tommi Nurminen⁹ and Robert B. M. Landewé¹⁰, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Endokrinologikum, Berlin, Germany, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Université Paris René Descartes and Hôpital Cochin, Paris, France, ⁶Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, ⁷Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany, ⁸Oregon Health and Sciences University, Portland, OR, ⁹UCB Pharma, Monheim, Germany, ¹⁰Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands
Background/Purpose: Previous reports of RAPID-axSpA (NCT01087762) demonstrated efficacy and safety of certolizumab pegol (CZP) in patients (pts) with axial spondyloarthritis (axSpA) including pts with ankylosing…
Abstract Number: 2938 • 2014 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of Subcutaneous Golimumab in Patients with Active Nonradiographic Axial Spondyloarthritis
J Sieper¹, D van der Heijde², M Dougados³, Walter P. Maksymowych⁴, J Boice⁵, G Bergman⁵, S Curtis⁵, A Tzontcheva⁵, S Huyck⁵ and HH Weng⁵, ¹University Clinic Benjamin Franklin, Berlin, Germany, ²Leiden University Medical Center, Leiden, Netherlands, ³Paris-Descartes University, Paris, France, ⁴Department of Medicine, University of Alberta, Alberta, AK, ⁵Merck & Co., Inc., Whitehouse Station, NJ
Background/Purpose Axial spondyloarthritis (axSpA), including ankylosing spondylitis and nonradiographic axial SpA (nr-axSpA), is a chronic inflammatory disease marked by back pain and progressive spinal stiffness.…
Abstract Number: 589 • 2014 ACR/ARHP Annual Meeting
Patients with Nr-Axspa Show a Statistically Higher Disease Burden in Clinical Practice Compared with Patients with Radiographic Axial Spa
Lennart TH Jacobsson¹, Tomas Husmark², Elke Theander³, Kenneth Henriksson⁴, Katharina Büsch⁵ and Martin Johansson⁵, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Rheumatology, Falu Hospital, Falun, Sweden, ³Skane University Hospital Malmö, Lund University, Malmö, Sweden, ⁴Rheumatology city clinic, Stockholm, Sweden, Stockholm, Sweden, ⁵AbbVie AB, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose The ASAS axial SpA classification criteria was published in 2009 but so far there has been limited research on axial SpA patients in clinical…
Abstract Number: 2604 • 2014 ACR/ARHP Annual Meeting
Ankylosing Spondylitis and Non- Radiographic Axial Spondyloarthritis : the Same Syndrome or Different Diseases? Analysis from Esperanza Cohort
Azucena Hernández-Sanz¹, Victoria Navarro-Compán², Cristina Fernández-Carballido³, Carlos Montilla-Morales⁴, Juan Mulero⁵ and Eugenio De Miguel⁶, ¹H. Virgen de la Salud, Toledo, Spain, ²Rheumatology, University Hospital La Paz, Madrid, Spain, ³Rheumatology, University General Hospital Elda, Elda (Alicante), Spain, ⁴H. de Salamanca, Salamanca, Spain, ⁵Rheumatology, University Hospital Puerta de Hierro, Majadahonda (Madrid), Spain, ⁶Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain
Background/Purpose New ASAS criteria for axial spondyloarthritis (axSpA) have two entrances: the imaging and clinical arm (presence of HLA B27). The imaging arm allows classifying patients…
Abstract Number: 585 • 2014 ACR/ARHP Annual Meeting
Optimism Levels Are Moderate and Similar in Patients with Axial Spondyloarthritis and Chronic Low Back Pain, and Are Related to Mental Quality of Life but Not Physical Quality of Life. a Cross Sectional Study of 277 Patients
Sarah Kreis^1,2,3, Anna Molto^2,3, Florian Bailly^2,3, Sabrina Dadoun^2,3, Stephanie Fabre^2,3,4, Christophe Hudry², Franck Zenasni⁵, Sylvie Rozenberg^2,3, Edouard Perthuiset⁴, Bruno Fautrel^2,6 and Laure Gossec^2,7, ¹Institut de Psychologie, Laboratoire de Psychopathologie et Processus de Santé EA4057, Université Paris Descartes, Boulogne-Billancourt, France, ²Sorbonne Universités, UPMC Univ Paris 06, GRC-08, Institut Pierre Louis d’Epidémiologie et de Santé Publique, paris, France, ³Pitié-Salpêtrière Hospital, AP-HP, Rheumatology department, paris, France, ⁴Pontoise University Hospital, pontoise, France, ⁵Institut de Psychologie, Laboratoire de Psychopathologie et Processus de Santé EA4057, Université Paris Descartes, Paris, France, Boulogne-Billancourt, France, ⁶Rheumatology, Pitie Salpetriere Hospital, Paris, France, ⁷Rheumatology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France
Background/Purpose Axial Spondyloarthritis (AxSpA) and chronic low back pain (LBP) are very different chronic rheumatic diseases in terms of physiopathology and prognosis but both have…
Abstract Number: 2584 • 2014 ACR/ARHP Annual Meeting
Smoking Is Not Associated with Response to TNF Blockers in Patients with Axial Spondyloarthritis
Anna Dellyes¹, Pierre Lafforgue¹, Vincent Pradel² and Thao Pham¹, ¹Rheumatology, APHM, Aix Marseille University, Marseille, France, ²Epidemiology, APHM, Aix Marseille University, Marseille, France
Background/Purpose Smoking has been reported as associated with increase disease activity, more functional impairment, poorer quality of life and more radiographic damages in patients (pts)…
Abstract Number: 581 • 2014 ACR/ARHP Annual Meeting
Evaluation of the Nonsteroidal Anti-Inflammatory Drug-Sparing Effect of Etanercept in Axial Spondyloarthritis: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Maxime Dougados¹, Emily Wood², Bernard Combe³, Corinne Miceli-Richard⁴, Francis Berenbaum⁵, Nandan Koppiker⁶, Arnaud Dubanchet⁷ and Isabelle Logeart⁷, ¹Université Paris René Descartes and Hôpital Cochin, Paris, France, ²Biostatistics, Quanticate, Hitchin, England, ³Immuno-Rhumatologie, Hôpital Lapeyronie, Montpellier, France, ⁴Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France, ⁵Service de Rhumatologie, Saint-Antoine Hospital, Paris, France, ⁶Pfizer PGRD, Sandwich, United Kingdom, ⁷Pfizer, Paris, France
Background/Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) are first-line pharmacotherapy in axial spondyloarthritis (axSpA) but are recommended for use at the lowest effective dose for the shortest…
Abstract Number: 2581 • 2014 ACR/ARHP Annual Meeting
Clinically Active Non-Radiographic Axial Spondyloarthritis Patients Who Initially Have a Negative MRI and Normal CRP May Develop a Positive MRI or Elevated CRP at a Later Timepoint
Xenofon Baraliakos¹, Joachim Sieper², Su Chen³, Aileen L. Pangan³ and Jaclyn K. Anderson³, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³AbbVie Inc., North Chicago, IL
Background/Purpose: Patients (pts) with non-radiographic axial spondyloarthritis (nr-axSpA) and active disease may have objective evidence of inflammation, either as bone marrow edema (BME) on magnetic…
Abstract Number: 580 • 2014 ACR/ARHP Annual Meeting
MRI Is Often Negative in Clinically Suspected Non-Radiographic Axial Spondyloarthritis
M.L. John¹, M.a.C. van der Weijden^1,2, C.M.a. van der Bijl¹, S.T.G. Bruijnen¹, C.J. van der Laken¹, M.T. Nurmohamed^1,2 and I.E. van der Horst-Bruinsma¹, ¹Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands
Background/Purpose The diagnosis of ankylosing spondylitis (AS) is based on disease specific bone damage seen on plain radiography of the pelvis. Recent developments in magnetic…
Abstract Number: 2578 • 2014 ACR/ARHP Annual Meeting
Disease Activity Is the Major Determinant of Quality of Life and Physical Function in Patients with Early Axial Spondyloarthritis. Results from the Esperanza Cohort.
Cristina Fernández-Carballido¹, Victoria Navarro-Compán², Mireia Moreno³, Xavier Juanola⁴, Juan Mulero⁵ and Eugenio De Miguel⁶, ¹Rheumatology, University General Hospital Elda, Elda (Alicante), Spain, ²Rheumatology, University Hospital La Paz and Leiden University Medical Center, Madrid, Spain, ³Rheumatology, University Hospital Parc Taulí, Sabadell, Spain, ⁴Rheumatology, University Hospital Bellvitge, Barcelona, Spain, ⁵Rheumatology, University Hospital Puerta de Hierro, Majadahonda (Madrid), Spain, ⁶Rheumatology, University Hospital La Paz - IdiPaz, Madrid, Spain
Background/Purpose : Main objective: to describe health related quality of life (HRQoL), physical function (PF) and spinal mobility (SM) in patients with early axial Spondyloarthritis…
Abstract Number: 562 • 2014 ACR/ARHP Annual Meeting
Clinical Response and Remission in Patients with Non-Radiographic Axial Spondyloarthritis after Three Years of Adalimumab Therapy
Désirée M. van der Heijde¹, Joachim Sieper², Walter P. Maksymowych³, Dominique L. Baeten⁴, Yinglin Xia⁵, Jaclyn K. Anderson⁵ and Aileen L. Pangan⁵, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁵AbbVie Inc., North Chicago, IL
Background/Purpose: Adalimumab (ADA) has been previously shown to be effective for the treatment of non-radiographic axial spondyloarthritis (nr-axSpA) patients (pts) in the ABILITY-1 trial.1 Week…
Abstract Number: 2577 • 2014 ACR/ARHP Annual Meeting
The Ankylosing Spondylitis Disease Activity Score More Closely Reflects MRI Parameters of Sacroiliitis Than the Bath Ankylosing Spondylitis Disease Activity Index in Patients with Non-Radiographic Axial Spondyloarthritis
Walter P. Maksymowych¹, S Wichuk¹, H Jones², A Szumski³, L Marshall², J Bukowski² and RG Lambert⁴, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Pfizer Inc., Collegeville, PA, ³Specialty Care, Pfizer Inc., Collegeville, PA, ⁴Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Validation of clinical measures of disease in non-radiographic axial SpA (nr-axSpA) has been limited, especially using inflammatory and structural lesions on MRI as gold…
Abstract Number: 577 • 2014 ACR/ARHP Annual Meeting
A Substantial Decrease in Work Productivity and Physical Health-Related Quality of Life in Chronic Back Pain of Recent Onset: Data from the SPACE-Cohort
A Roeterink¹, M de Hooge², R. van den Berg², H Dagfinrud³, M Turina⁴, M. van Oosterhout⁵, D. van der Heijde¹ and F van Gaalen², ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Oslo City Dept of Rheumat, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Groene Hartziekenhuis, Gouda, Netherlands
Background/Purpose: Ankylosing spondylitis is associated with work productivity (WP) loss and a decreased health-related quality of life (HRQoL). Little is known about WP loss and…

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