Abstracts tagged "autophagy proteins"

Abstract Number: 52 • 2019 ACR/ARP Annual Meeting
Autophagy Protein Microtubule-associated Protein 1 Light chain-3B (LC3B) Regulates Joint Inflammation and Destruction in Rheumatoid Arthritis
sangyoun jung¹, sookon lee ¹ and jinjung choi ¹, ¹CHA Bundang Medical Center, Seongnam-si, Kyonggi-do, Republic of Korea
Background/Purpose: Here, we assumed that intracellular autophagy mechanism and its protein microtubule-associated protein 1 light chain-3B (LC3B) play an important role in the synovial fibroblasts…
Abstract Number: 1949 • 2019 ACR/ARP Annual Meeting
The p.R321C Mutation in P62 Associated with Paget’s Disease of Bone Leads to a Change of Localization of the Protein in Human Osteoclasts
Nerea Gestoso-Uzal ¹, Ricardo Usategui-Martín ¹, Rogelio González-Sarmiento ¹ and Javier Del Pino-Montes¹, ¹Salamanca Institute of Biomedical Research (IBSAL), University Hospital of Salamanca- University of Salamanca, Salamanca-CSIC, Spain, Salamanca, Castilla y Leon, Spain
Background/Purpose: Paget´s disease of bone (PDB) is a chronic bone metabolic disorder. Currently, PDB is a focal disorder characterized by an increase in bone turnover…
Abstract Number: 8 • 2015 ACR/ARHP Annual Meeting
Bay 11-7085 Induces Glucocorticoid Receptor Activation and Autophagy to Initiate Human Synovial Fibroblast Cell Death
Biserka Relic¹, Edith Charlier², Céline Deroyer¹, Olivier Malaise¹, Sophie Neuville¹, Aline Desoroux¹, Philippe Gillet³, Michel G. Malaise¹ and Dominique de Seny¹, ¹Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, ²Department of Rheumatology, Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, ³Orthopaedic Surgery Department-University of Liège-CHU de Liège, Liège, Belgium
Background/Purpose: BAY 11-7085 is an inhibitor of IκBα phosphorylation that leads to NF-κB inactivation and downregulation of inflammation in mouse model of asthma, in articular…

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