Abstracts tagged "autophagy and spondylarthritis"

Abstract Number: 653 • 2017 ACR/ARHP Annual Meeting
Reduced Ubiquitination of Misfolded HLA-B27 Is Associated with Inefficient Degradation By ERAD and Autophagy
Fatemeh Navid¹, Gerlinde Layh-Schmitt¹, Keith A. Sikora² and Robert Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Pediatric Translational Research Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: The HLA class I allele, HLA-B27, is associated with spondyloarthritis (SpA), an immune-mediated inflammatory disease affecting the axial skeletal, skin, gut and eyes. HLA-B27…
Abstract Number: 2826 • 2015 ACR/ARHP Annual Meeting
Stimulation of Autophagy Reduces Misfolded HLA-B27 in a Rat Model of Spondyloarthritis
Fatemeh Navid¹, Gerlinde Layh-Schmitt¹ and Robert A. Colbert², ¹NIAMS/NIH, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: HLA-B27/human β2microglobulin transgenic rats develop spondyloarthritis (SpA) characterized by inflammation in the gut and peripheral joints by mechanisms that remain poorly defined, but do…

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