ACR Meeting Abstracts

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Abstracts tagged "Autoinflammatory diseases"

  • Abstract Number: 0400 • ACR Convergence 2024

    Osteoclastogenesis from Peripheral Blood Mononuclear Cells in Children with Chronic Nonbacterial Osteomyelitis Are Similar to Those from Healthy Children

    Jacqueline Bui1, Jacob Curry2, Jessica Kent3, Payton Danosky4, Kellen Sanders4, Sriya Paluvayi4, Wendy Garcia4, Alejandra Ruppe4, Megan Cheung4, Anna Saack4, Xinrui Bao4, Audrey Luey4, Michelle Kim4, Emily McDaniel4, Amanda Chiu4, Sophia Ahn5, Ji-Won Park4, Sudheshna Thirunahari4, Cammie Wei4, Liau Adriel5, Sophia Pham4, Sadie Van Den Bogaerde4, Joshua Scheck4, Ian Muse6, Ava Klein5, Xing Wang7, James Cassat8 and Yongdong Zhao6, 1Seattle Children’s Research Institute, University of Washington, Bellevue, WA, 2Seattle Children’s Research Institute, Vanderbilt University Medical Center, Seattle, WA, 3Seattle Children’s Research Institute, Medical College of Wisconsin, Seattle, WA, 4Seattle Children’s Research Institute, University of Washington, Seattle, WA, 5Seattle Children’s Research Institute, University of Washington, Seattle, 6Seattle Children's Research institute, Seattle, WA, 7Biostatistics Epidemiology and Analytics in Research, Seattle Children’s Research Institute, Seattle, WA, 8Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disease in which osteoclastogenesis may play a critical role. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) was shown…
  • Abstract Number: 0999 • ACR Convergence 2024

    Clinical and Biological Features of VEXAS Syndrome in Women: Study of 9 French Cases Compared with 263 Men

    Rim Bourguiba1, Valentin Lacombe2, Vincent Jachiet3, Thibault Comont4, Joris Galland5, Mael Heiblig6, Alexandre Nguyen7, Achille Aouba8, Xavier Boulu9, Alexandre Curie10, Pierre Sujobert11, Pierre Hirsch12, Olivier Kosmider13, Arsene Mekinian14 and Sophie Georgin-lavialle15, and French VEXAS study group, 1Hopital des Forces de sécurité de l'interieur, La Marsa, Tunisia, 2Angers University Hospital, Angers, France, 3Service de Médecine intene, Hopital Saint-Antoine, Paris France, Paris, France, 44 Service de médecine interne, Hopital Toulouse, France, Toulouse, France, 5Service de médecine interne, Centre hospitalier de Bourg- En-Bresse, France, Bourg en Bresse, France, 6Service de médecine interne, Centre Hospitalier Lyon Sud, Lyon, France, 7Service de médecine interne, CHU Cean, France, Cean, France, 8Service d'immunologie clinique-médecine interne, CHU de Caen Normandie, Caen, France, 98 Service de médecine interne, CHU Amiens Picardie, France, Amiens, France, 10Service de médecine interne, CH Eure Seine, France, Eure seine, France, 11Service d'hématologie, Centre Hospitalier Lyon Sud, France, Lyon, Tunisia, 12Hopital Saint-Antoine, Paris, France, Paris, France, 13Hematology Laboratory, Assistance Publique-Hôpitaux de Paris, Centre-Université de Paris Cité, Cochin Hospital, Paris, France, Paris, France, 14Saint Antoine University Hospital, Paris, France, 15Sorbonne Université, Department of internal medicine, Tenon Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

    Background/Purpose: VEXAS syndrome is an autoinflammatory disease associated with somatic mutations in the UBA1 gene, which is located on the X chromosome, which explains the…
  • Abstract Number: 1773 • ACR Convergence 2024

    Divergent Genetic Architecture in Boys and Girls with NEMO-deleted Exon 5 Autoinflammatory Syndrome (NEMO-NDAS) Implies Role for Wildtype Effector Cells

    Adriana Almeida de Jesus1, Kip Friend2, Bin Lin3, Eric Karlins4, Colton McNinch4, Sara Alehashemi5, Keith Kauffman6, FARZANA BHUYAN3, Taylor Newbolt6, Andrea Bohrer7, Andre Rastegar3, Sophia Park3, Dana Kahle3, Jacob Mitchell3, Amanda Chen3, Sofia Torreggiani8, Kader Cetin Gedik9, Katsiaryna Uss2, Amer Khojah10, Eveline Wu11, Christiaan Scott12, Timothy Ronan Leahy13, Emma MacDermott14, Orla Killeen15, Thaschawee Arkachaisri16, Brian Nolan17, Zoran Gucev18, Kathryn Cook19, Vafa Mammadova20, Gulnara Nasrullayeva20, Mariana Correia Marques21, Abigail Bosk22, Seza Ozen23, Scott Canna24, Maude Tusseau25, Emilie Chopin26, Guilaine Boursier27, Veronique Hentgen28, Ines Elhani29, Mario Sestan30, Marija Jelusic31, Danielle Fink32, Douglas Kuhns32, Clifton Dalgard33, Alexandre Belot34, Timothy Moran11, Katherine Meyer-Barber7, Andrew Oler4, Daniel Barber6 and Raphaela Goldbach-Mansky35, 1NIAID, NIH, Silver Spring, MD, 2Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Bethesda, MD, 3TADS, NIAID, NIH, Bethesda, MD, 4BCBB, NIAID, NIH, Bethesda, MD, 5NIH/NIAID/TADS, Potomac, MD, 6T Lymphocyte Biology Section, LPD, NIAID, NIH, Bethesda, MD, 7Inflammation and Innate Immunity Unit, LCIM, NIAID, NIH, Bethesda, MD, 8University Of Maryland Baltimore, Baltimore, MD, 9Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Pittsburgh, PA, 10Umm Al-Qura University, Makkah, Saudi Arabia, 11University of North Carolina School of Medicine, Chapel Hill, NC, 12University of Cape Town, Cape Town, South Africa, 13Children’s Health Ireland (CHI) at Crumlin, Dublin, Ireland, 14CHI Crumlin, Dublin, Dublin, Ireland, 15Children's Health Ireland, Dublin, Ireland, 16KK Women's and Children's Hospital, SingHealth, Singapore, Singapore, 17Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, IL, 18University Children's Hospital, Skopje, Macedonia, 19Akron Children's Hospital, Akron, OH, 20Azerbaijan Medical University, Baku, Azerbaijan, 21National Institutes of Health, Bethesda, MD, 22Children's National Hospital, Bethesda, DC, 23Department of Pediatrics, Hacettepe University, Ankara, Turkey, 24Children's Hospital of Philadelphia, Philadelphia, PA, 25RAISE, Hospices Civils de Lyon, Lyon, France, 26Hospices Civils de Lyon, Lyon, France, 27University of Montpellier, Montpellier, 28Laboratoire de Génétique des Maladies Rares et Autoinflammatoires, Département de Génétique Médicale, Maladies Rares et Médecine Personnalisée, CEREMAIA, CHU de Montpellier, Univ Montpellier, Montpellier, France, Le Chesnay, France, 29Department of Internal Medicine, Caen University Hospital, Caen, France, Caen, France, 30University of Zagreb School of Medicine University Hospital Centre Zagreb, Zagreb, Croatia, 31University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Zagreb, Croatia, 32Collaborative Clinical Research Branch, NIAID, NIH, Bethesda, MD, Bethesda, MD, 33The American Genome Center, Department of Anatomy, Physiology & Genetics, Uniformed Services University, Bethesda, MD, 34Hospices Civils de Lyon, Collonges au mont d'or, France, 35Translational Autoinflammatory Diseases section (TADS), LCIM, NIAID, NIH, Potomac, MD

    Background/Purpose: Splice-site variants in X-linked IKBKG cause NEMO-deleted exon5 autoinflammatory syndrome (NEMO-NDAS); a pseudogene (IKBKGP1) complicates genetic diagnosis. NEMO-NDAS is four times more common in…
  • Abstract Number: 2044 • ACR Convergence 2024

    Clinical Practice Patterns, Rilonacept Appropriate Use for Recurrent Pericarditis

    Jessica Farrell1, Michael Allen2, Lee Shapiro3, Victoria Michaels4, Arifa Javed5, Nabiha Qureshi6, Summia Matin Afridi7, Shahad Almahmoud8, Getzabeth Bosques Gomez9 and Khoa Richard Ngo10, 1Albany College of Pharmacy & Health Sciences/Albany Medical Center, Delmar, NY, 2Albany Medical Center, Delmar, NY, 3Albany Medical College, Stillwater, NY, 4Albany Medical Center, Wynantskill, NY, 5Albany Medical Center, Rensselaer, NY, 6Albany Medical Center, Menands, NY, 7Albany Medical Center, Albany, NY, 8Albany College of Pharmacy & Health Sciences/Albany Medical Center, Albany, NY, 9Albany College of Pharmacy and Health Sciences/Albany Medical Center, Albany, NY, 10Albany Medical Center, Voorheesville, NY

    Background/Purpose: Pericarditis is inflammation of the pericardial sac which can be of infectious or non-infectious etiology, commonly associated with rheumatic diseases. Pericarditis is defined as…
  • Abstract Number: 2659 • ACR Convergence 2024

    A Comprehensive Approach Utilizing a Combination of Genetics, Cytological Analysis, and Imaging Techniques to Speed up the Diagnostic Process in VEXAS Patients

    Sara Bindoli1, Chiara Baggio2, Roberto Padoan3, Riccardo Bixio4, doria Andrea5, Roberta Ramonda2 and Paolo Sfriso1, 1Rheumatology Unit, University of Padova, Italy, Padova, Veneto, Italy, 2Rheumatology Unit, University of Padova, Italy, Padova, Italy, 3Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padua, Italy, 4University of Verona, Verona, Verona, Italy, 5University of Padova, Padova, Italy

    Background/Purpose: VEXAS is a newly described “haemato-autoinflammatory” condition resulting from somatic mutations in the UBA-1 gene. By integrating genetics, cytology and imaging, this work seeks…
  • Abstract Number: 0006 • ACR Convergence 2024

    NX-5948, a Clinical-Stage BTK Degrader, Achieves Deep Suppression of BCR, TLR, and FcR Signaling in Immune Cells and Demonstrates Efficacy in Preclinical Models of Arthritis and Other Inflammatory Diseases

    Mark Noviski1, Jun Ma1, Nivetha Brathaban1, Aishwarya Kumar1, Dhwani Haria1, Jenny McKinnell1, Robert Cass1, Frederick Cohen1, Davorka Messmer2, Gwenn Hansen1 and Ryan Rountree1, 1Nurix Therapeutics, San Francisco, CA, 2Nurix Therapeutics, San Diego, CA

    Background/Purpose: Bruton’s tyrosine kinase (BTK) mediates signaling downstream of the B cell receptor (BCR), toll-like receptors (TLRs), and Fc receptors (FcRs). This makes BTK an…
  • Abstract Number: 0408 • ACR Convergence 2024

    Analysis of Protein Biomarkers for the Prediction of IL-1 Inhibitor Treatment Response in the CARRA First-line Options for Systemic Juvenile Idiopathic Arthritis Treatment (FROST) Study

    Michael Matt1, Mariana Correia Marques2, Sabrina Fuehner3, Lexi Auld1, George Tomlinson4, Michael Ombrello5, Yukiko Kimura6, Christoph Kessel7 and grant schulert1, and the CARRA FROST Investigators, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2National Institutes of Health, Bethesda, MD, 3Universitaetsklinikum Muenster, Muenster, Germany, 4University of Toronto, Toronto, ON, Canada, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 6Hackensack Meridian School of Medicine, New York, NY, 7University Hospital Muenster, Muenster, Germany

    Background/Purpose: IL-1 inhibitors are both widely used and highly effective as first-line therapy for children with systemic juvenile idiopathic arthritis (sJIA); however, the mechanisms underlying…
  • Abstract Number: 1062 • ACR Convergence 2024

    Assessing Musculoskeletal Symptom Burden in a Cohort of Patients with Hidradenitis Suppurativa Using the IDEOM MSK-Q

    Gretchen Ball1, Hassan Hamade2, Sarah Romanelli2, Zachary Levy2, Lourdes Perez Chada3, Joseph Merola4 and Alice Gottlieb5, 1Albert Einstein College of Medicine, Ridgefield, CT, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 4UT Southwestern Medical Center, Newton, MA, 5Icahn School of Medicine at Mount Sinai, Department of Dermatology, Seattle, WA

    Background/Purpose: Hidradenitis suppurativa (HS) has been associated with inflammatory joint diseases such as psoriatic arthritis and ankylosing spondylitis.  Despite this correlation, dermatologists do not routinely…
  • Abstract Number: 1778 • ACR Convergence 2024

    A Novel Variant in IRAK2 Results in Immune Dysregulation in Systemic Juvenile Idiopathic Arthritis (sJIA)

    Mariana Correia Marques1, Brooke Boyd2, Alana Platukus3, Elizabeth Schmitz2, Hiroto Nakano2, Faiza Naz4, Anthony Cruz1, Stefania Dell'Orso4, Zuoming deng4 and Michael Ombrello5, 1National Institutes of Health, Bethesda, MD, 2Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, Bethesda, MD, 31Translational Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, Bethesda, MD, 4National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD

    Background/Purpose: Lung disease (LD) is poorly understood complication of Still’s disease with high fatality. HLA-DRB1*15 is a strong risk factor for the development of this…
  • Abstract Number: 2046 • ACR Convergence 2024

    Duration of Disease and Long-term Outcomes in Patients with Difficult-to-treat Recurrent Pericarditis: A Chronic Condition Treated with NSAIDs, Colchicine, Corticosteroids, and Anti-IL-1 Agents

    Antonio Brucato1, Elisa Ceriani2, Francesco Agozzino3, Silvia Berra4, Antonio Gidaro2, Silvia Macchi5, Letizia Vena5, Paolo Bindi5, Alberto Pavarani6, Francesco Moda7, Ludovico Luca Sicignano8, Celeste Murace8, Elena Verrecchia8, Caterina Chiara Decarlini9, Silvia Maestroni10, Gabriella Marinaro4, Lucia Trotta3, Massimo Pancrazi3, Lisa Serati3, Enrica Negro3, Claudia Gabiati3, Elisa Calabrò3, Angela Mauro11, Luisa Carrozzo3, Emanuele Bizzi3 and Massimo Imazio12, 1Department of Biomedical and Clinical Sciences, University of Milano, Department of Internal Medicine, Ospedale Fatebeneratelli, Milano, Milano, Lombardia, Italy, 2Department of Internal Medicine, Ospedale Luigi Sacco, Milano, Milan, Italy, 3Department of Internal Medicine, Ospedale Fatebeneratelli, Milano, Milan, Italy, 4Department of Internal Medicine, Ospedale Fatebeneratelli, Milano, Milano, Italy, 5University of Milano, Milan, Italy, 6University of Milano, Milan, 7Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 8Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Rome, Italy, 9Cardiology Division, Cardiovascular Department, San L. Mandic Hospital, Merate, Lecco, Italy, 10Internal Medicine Department, Papa Giovanni XXIII Hospital, Bergamo, Bergamo, Italy, 11Pediatric Rheumatology Unit, Department of Childhood and Developmental Medicine, Fatebenefratelli-Sacco Hospital, Milan, Italy, 12University of Udine, and Cardiothoracic Department, University Hospital Santa Maria della Misericordia, Udine, Milan, Italy

    Background/Purpose: Recurrent pericarditis (RP) challenges pts and clinicians in terms of long-term management. Objective of this study was to evaluate the remission rate (drug-free for…
  • Abstract Number: 2660 • ACR Convergence 2024

    Developing Predictive Models for the Diagnosis of VEXAS Syndrome

    Daniel Montes1, Andrew C. Hanson2, Hannah Langenfeld1, Cynthia Crowson1, Mrinal Patnaik1, Ronald Go1, Alexander Hines1, Kambiz Kalantari1, Yael Kusne3, Terra Lasho2, Abhishek Mangaonkar1, Horatiu Olteanu1, Kaaren Reichard1, Megan Sullivan4, David Viswanatha1, Kenneth Warrington1 and Matthew Koster1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, 3Mayo Clinic, Phoenix, AZ, 4Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a recently identified autoinflammatory disorder with a heterogenous presentation. Patients may experience delays in diagnosis…
  • Abstract Number: 0072 • ACR Convergence 2024

    The Association Between Activation of Inflammasome and HLA-B27 in Dendritic Cells of Patients with Axial Spondyloarthritis

    Jina Yeo1, Min-Gang Kim2, Hye Eun Lee3, Yeonsoo Yang2, Mi Ryoung Seo1, Hyo-Jin Choi1, Eun Young Lee4, Dae Ho Lee3 and Han Joo Baek5, 1Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, 2Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea, 3Division of Endocrinology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea, 43Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea, 5Division of Rheumatology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Inchon, South Africa

    Background/Purpose: Axial spondyloarthritis (axSpA) exhibits a predominant involvement of the innate immune system, marked by abnormal functions of innate immune cell such as dendritic cells…
  • Abstract Number: 0414 • ACR Convergence 2024

    Relationship Between Culture Negative Infectious Osteomyelitis and Chronic Nonbacterial Osteomyelitis

    Andrew Grim1, Yongdong (Dan) Zhao2, Christine Wang1, Erin Janssen3, Jessica Turnier4, Anastasia Hyrhorczuk1 and Nadine Saad1, 1University of Michigan, Ann Arbor, MI, 2University of Washington, Redmond, WA, 3CS Mott Children's Hospital, Ann Arbor, MI, 4University of Michigan, Saline, MI

    Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder. Some patients with CNO may present acutely and be misdiagnosed as infectious osteomyelitis (IO).…
  • Abstract Number: 1112 • ACR Convergence 2024

    Pleuroparenchymal Fibroelastosis Associated with Connective Tissue Diseases (PPFE-CTD)

    Maximiliano Diaz Menindez1, Alejandro Diaz Arumir Vergara2, Vivian Shing2, carolyn mead harvey3, Ana Zamora Martinez2 and Vivek Nagaraja4, 1Mayo Clinic School of Graduate Medical Education, Phoenix, AZ, 2Mayo Clinic, Phoenix, 3Mayo Clinic Florida, Jacksonville, FL, 4Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: Pleuroparenchymal Fibroelastosis (PPFE) is a rare idiopathic interstitial pneumonia characterized by fibrosis of the visceral pleura and subpleural parenchyma, predominantly affecting the upper lobes.…
  • Abstract Number: 1788 • ACR Convergence 2024

    Memory B Cell Activation and Dysregulation in Systemic Lupus Erythematosus

    Shady Younis1, Salvinaz Moutusy2, Shaghayegh Jahanbani2, Xiaohao Wu2, Marlayna Harris2, Mahesh Pandit3, Laura van Dam4, orr Sharpe5, Paul Utz1 and William Robinson6, 1Stanford University, Stanford, CA, 2Stanford University School of Medicine, Stanford, 3Stanford University School of Medicine, Stanofrd, 4Stanford, Palo Alto, CA, 5Department of Immunology and Rheumatology, Stanford University, Stanford, CA, 6Division of Immunology and Rheumatology, Stanford University, and VA Palo Alto Health Care System, Stanford, CA

    Background/Purpose: B cell dysregulation and production of autoantibodies against autoantigens are hallmarks of Systemic lupus erythematosus (SLE). In healthy adults (HC), B cells with autoreactive…
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