Abstracts tagged "Autoinflammatory Disease and Interferonopathies"

Abstract Number: 814 • 2019 ACR/ARP Annual Meeting
Interferon Signature and Cytokine Patterns Define Novel Autoinflammatory Diseases
Adriana de Jesus¹, Yangfeng Hou ², Stephen Brooks ³, Louise Malle ⁴, Angelique Biancotto ⁵, Yan Huang ⁶, Katherine Calvo ⁷, Bernadette Marrero ⁸, Susan Moir ⁹, Andrew Oler ¹⁰, Zuoming Deng ³, Gina Montealegre Sanchez ¹, Scott Canna ¹¹ and Raphaela Goldbach-Mansky ¹², ¹Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, ²Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China (People's Republic), ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, ⁵NIH/CHI, Bethesda, ⁶Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, MD, ⁷Hematology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ⁸Computational Systems Biology Section/NIAID/NIH, Bethesda, ⁹Immunopathogenesis Section/NIAID/NIH, Bethesda, MD, ¹⁰NIH/NIAID, Bethesda, ¹¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, ¹²Translational Autoinflammatory Diseases Section/NIAID/NIH, Bethesda, MD
Background/Purpose: Undifferentiated systemic autoinflammatory diseases (USAID) present diagnostic and therapeutic challenges. Cytokine dysregulation may identify disease groups that respond to targeted treatments. IFN-signaling blocking treatments…

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