Abstracts tagged "Autoimmunity"

Abstract Number: 634 • 2013 ACR/ARHP Annual Meeting
IL-21/IL-21R Interaction On Lymphocyte Subsets From Lupus Patients
Vinh Nguyen¹, Horea Rus², Cosmin Tegla² and Violeta Rus³, ¹Medicine, University of Maryland School of Medicine, Baltimore, MD, ²Neurology, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD, ³Medicine, University of Maryland School of Medicine and Veteran Affairs Medical Center, Baltimore, MD
Background/Purpose: We have previously shown that IL-21 promotes autoimmunity in a mouse model of lupus through both CD4 and B cell intrinsic mechanisms. Recent studies…
Abstract Number: 565 • 2013 ACR/ARHP Annual Meeting
Differential Efficacy Of Human Mesenchymal Stem Cells On Disease In Murine Lupus Based On Source Of Origin
Erin Collins¹, Fei Gu², Osama S. Naga¹, Phil Ruiz³ and Gary S. Gilkeson⁴, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology,Medical University of South Carolina, Charleston, SC, ³Pathology, University of Miami, Miami, FL, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that targets multiple organ systems. Current treatment options for SLE often cause non-specific immune suppression,…
Abstract Number: 116 • 2013 ACR/ARHP Annual Meeting
Lack Of Association Between Preclinical Markers For Cardiovascular Disease and Rheumatoid Arthritis-Related Autoimmunity In First-Degree Relatives Without Rheumatoid Arthritis
Jill M. Norris¹, Ryan W. Gan¹, Jan M. Hughes-Austin², Kevin D. Deane³, M. Kristen Demoruelle³, Elaine M. Urbina⁴, Kerrie Moreau⁵, Peter K. Gregersen⁶, Michael H. Weisman⁷ and V. Michael Holers⁸, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Preventive Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Medicine, University of Colorado School of Medicine, Aurora, CO, ⁶Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁷Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Rheumatoid arthritis (RA) is characterized by systemic inflammation and immune dysregulation, including the presence of autoantibodies and elevated inflammatory biomarkers in subjects with classifiable…

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