Abstracts tagged "Autoimmunity"

Abstract Number: 760 • 2016 ACR/ARHP Annual Meeting
Effects of Type I Interferon Inhibition on Blood Leukocyte Subsets in Patients Treated in a Phase IIb Clinical Study of Anifrolumab in SLE
Geoffrey Stephens¹, Rong Zeng², Xiang Guo², Steve Eck³, Yuling Wu³, Liangwei Wang³, Gabor Illei³ and Wendy White², ¹Cellcion, Clarksburg, MD, ²Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ³MedImmune, LLC, Gaithersburg, MD
Background/Purpose: A Phase IIb randomized controlled study (NCT01753193) was conducted with anifrolumab, a fully human, anti-interferon (IFN)–α receptor (IFNAR1) specific antibody in adults with moderate…
Abstract Number: 2712 • 2016 ACR/ARHP Annual Meeting
Inverse Correlation Between IL-10-Producing Bregs and IFN-Gamma-Producing NK Cells in Psoriatic Arthritis and Psoriasis
Athanasios Mavropoulos¹, Areti Varna¹, Christos Liaskos¹, Efterpi Zafiriou², Marianna Vlychou³, Christina Katsiari⁴, Dimitrios Bogdanos⁵ and Lazaros I. Sakkas⁶, ¹Department of Rheumatology, School of Health Sciences, University of Thessaly, Larissa, Greece, ²Dermatology, University of Thessaly, Larissa, Greece, ³Radiology, University of Thessaly, Larissa, Greece, ⁴Department of Rheumatology, University of Thessaly, Larrisa, Thessaly, Greece, ⁵Department of Rheumatology, University of Thessaly, Larissa, Greece, ⁶University, Athens, Greece
Background/Purpose: A recent study from our group has shown functional impairment and numerical decrease of transitional and memory IL-10-producing regulatory B cells (Bregs) in patients…
Abstract Number: 2835 • 2016 ACR/ARHP Annual Meeting
Longitudinal Analysis of Th1 and Th2 Cytokines in Systemic Lupus Erythematosus
Mariana Postal¹, Karina O. Peliçari¹, Nailu A. Sinicato², Aline Tamires Lapa¹, Fernando A. Peres¹, André Moreno Morcillo³, Lilian TL Costallat³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Pediatrics, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Division of Rheumatology, Faculty of Medical Science, State University of Campinas, São Paulo, Brazil
Background/Purpose: While autoantibodies production and immune complex deposition are cornered as hallmark features of systemic lupus erythematosus (SLE), there is growing evidence to propose the…
Abstract Number: 2885 • 2016 ACR/ARHP Annual Meeting
Expression Levels and Function of the Inhibitory Molecule, Immunoglobulin like Transcript 7 (ILT7), Are Decreased on Circulating Plasmacytoid Dendritic Cells in SLE Patients with High ANA Titers
Mark A. Jensen¹, Jessica M. Dorschner², Danielle Vsetecka², Shreyasee Amin³, Ashima Makol³, Floranne C. Ernste⁴, Thomas Osborn³, Kevin Moder³, Vaidehi Chowdhary³ and Timothy B. Niewold⁵, ¹Department of Immunology and Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁵Rheumatology and Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: Systemic lupus erythematous (SLE) is a complex autoimmune disease often involving multiple organs. In SLE, immune complexes containing autoreactive antibody and nuclear material activate…
Abstract Number: 806 • 2015 ACR/ARHP Annual Meeting
STAT1 Activation Promotes TLR8 Overexpression and Facilitates Mirokine Signaling Via Exosomes Containing a Mir-21 Endogenous Ligand: A Novel Innate Inflammatory Pathway in Systemic Lupus Erythematosus
Giancarlo R. Valiente^1,2, Nicholas A. Young², Lai-Chu Wu^3,4, Jeffrey Hampton⁵, Mary Severin⁶, Amy Lovett-Racke⁶ and Wael N. Jarjour⁷, ¹Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, ⁵Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH, ⁷Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The adaptive arm of the immune system plays a significant role in the pathophysiology of Systemic Lupus Erythematosus (SLE). However, recent studies suggest that…
Abstract Number: 1101 • 2015 ACR/ARHP Annual Meeting
Matrix Metalloproteinase-10 (Stromelysin 2) Is a Target of Robust Autoimmune T and B Cell Responses in Antibiotic-Refractory Lyme Arthritis, but Not in Rheumatoid Arthritis
Jameson T. Crowley¹, Elise E. Drouin², Annalisa Pianta¹, Klemen Strle¹, Qi Wang³, Catherine E. Costello³ and Allen C. Steere⁴, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁴Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Infection-induced autoimmunity has been hypothesized to have a pathogenic role in antibiotic-refractory Lyme arthritis (LA). We previously identified 3 autoantigens, endothelial cell growth factor,…
Abstract Number: 1950 • 2015 ACR/ARHP Annual Meeting
Methylation-Dependent Interference of Two Promoters for the Treg-Specific Protein, Garp, Contributes to Altered Treg Function in Rheumatoid Arthritis
Viktoria Soentgerath¹, Sonja Haupt², Jan Leipe³, Hendrik Schulze-Koops¹ and Alla Skapenko¹, ¹Division of Rheumatology and Clinical Immunology, University of Munich, Munich, Germany, ²Division of Rheumatology and Clinical Immunology, Med.Klinik und Poliklinik IV, University of Munich, Munich, Germany, ³Division of Rheumatology, University of Munich, Munich, Germany
Background/Purpose: Recently, genome-wide studies identified several Treg-specific genes containing hypomethylated regions that are critical for their expression, so called Treg-specific demethylated regions (TSDR). For example,…
Abstract Number: 1952 • 2015 ACR/ARHP Annual Meeting
Lack of Association of a 6.7 Kbp Deletion of LILRA3 with Giant Cell Arteritis
Ana Márquez¹, Tamara Fernández-Aranguren², Maria C. Cid³, José Hernández-Rodríguez³, Roser Solans⁴, Marc Ramentol⁴, Santos Castañeda⁵, Jose A. Miranda-Filloy⁶, Inmaculada C. Morado⁷, Javier Narváez⁸, Eugenio De Miguel⁹, Bernardo Sopeña¹⁰, Jordi Monfort¹¹, Maria Jesus Garcia-Villanueva¹², Norberto Ortego-Centeno¹³, Torsten Witte¹⁴, Miguel Angel Gonzalez-Gay¹⁵, Javier Martín² and Spanish GCA Group, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada and Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ²Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ³Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁴Autoimmune Systemic Diseases Unit, Department of Internal Medicine, Hospital Vall d’Hebron, Autonomous University of Barcelona, Barcelona, Spain, ⁵Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ⁶Department of Rheumatology, Hospital Xeral-Calde, Lugo, Spain, ⁷Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁸Rheumatology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, ⁹Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ¹⁰Department of Internal Medicine, Complejo Hospitalario Universitario de Vigo, Vigo, Spain, ¹¹Department of Rheumatology, Grup de recerca cel•lular en inflamació i cartílag. IMIM (Institut de Recerca Hospital del Mar), Barcelona, Spain, ¹²Department of Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ¹³Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ¹⁴Hannover Medical School, Hanover, Germany, ¹⁵Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain
Background/Purpose: Leukocyte immunoglobulin-like receptor A3 (LILRA3A) encodes a member of a family of immunoreceptors which is predominantly expressed on antigen presenting cells, acting as a…
Abstract Number: 2072 • 2015 ACR/ARHP Annual Meeting
Mitochondrial Reactive Oxygen Species Modulate Autoimmunity in Systemic Lupus Erythematosus
Luz P. Blanco¹, Christian Lood², Monica Purmalek³, Suk See DeRavin⁴, Carolyne K. Smith³, Carmelo Carmona-Rivera³, Harry Malech⁴, Jeffrey Ledbetter⁵, Keith B. Elkon⁶ and Mariana J. Kaplan¹, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Internal Medicine, University of Washington, Seattle, WA, ³Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴NIAID/NIH, Bethesda, MD, ⁵University of Washington, Seattle, WA, ⁶Department of Medicine & Immunology, University of Washington, Seattle, WA
Background/Purpose: Dysregulation in the formation of neutrophil extracellular traps (NETs) may contribute to modification and externalization of autoantigens and to organ damage in diverse autoimmune…
Abstract Number: 272 • 2015 ACR/ARHP Annual Meeting
Are the Autoimmune/Inflammatory Syndrome Induced By Adjuvants (ASIA) and the Undifferentiated Connective Tissue Disease (UCTD) Related to Each Other? a Case-Control Study of Environmental Exposures
Francesco Scanzi¹, Laura Andreoli¹, Maria Martinelli¹, Mara Taraborelli², Ilaria Cavazzana¹, Roberta Ottaviani¹, Nice Carabellese¹, Flavio Allegri¹, Franco Franceschini¹, Nancy Agmon-Levin³, Yehuda Shoenfeld⁴ and Angela Tincani¹, ¹Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ³Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv, Israel, ⁴Zabludowicz Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, Israel Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel
Background/Purpose: The Autoimmune/Inflammatory Syndrome induced by adjuvants (ASIA) [1] is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with…
Abstract Number: 632 • 2015 ACR/ARHP Annual Meeting
Isolated Atrioventricular Block of Unknown Origin in the Adult and Autoimmunity: Diagnostic and Therapeutic Considerations Exemplified By Three Anti-Ro/SSA-Associated Cases
Antonio Brucato¹, Pietro Enea Lazzerini², Pier Leopoldo Capecchi³, Anna Valenti⁴, Lucia Baldi⁵, Maria Romana Bacarelli³, Claudia Nucci⁵, Valentina Moscadelli³, Gabriella Morozzi³, Mohamed Butjdir^6,7,8 and Franco Laghi Pasini³, ¹Internal Medicine, Ospedale Papa Giovanni XXIII Bergamo, Bergamo, Italy, ²Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, ³Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy, ⁴Internal Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy, ⁵Cardiology, University of Siena, Siena, Italy, ⁶Medicine, Cell Biology and Pharmacology, State University of New York at Downstate Medical Center, New York, NY, ⁷NYU School of Medicine, New York, NY, ⁸Research Department, VA New York Harbor Healthcare System, New York, NY
Background/Purpose: Circulating anti-Ro/SSA antibodies may rarely affect the adult conduction-system. A direct autoantibody-mediated electrophysiological inhibition of cardiomyocyte calcium-channels (acquired form) or an ante-natal subclinical injury…
Abstract Number: 2726 • 2014 ACR/ARHP Annual Meeting
CD28null T Cells from Polymyositis Patients Are Cytotoxic to Autologous Muscle Cells in Vitro Via Perforin-Dependent Mechanisms
Jayesh Pandya¹, Paulius Venalis¹, Lubna Al-Khalili², Mohammad Shahadat Hossain¹, Ingrid E. Lundberg¹, Vivianne Malmström¹ and Andreas E. R. Fasth¹, ¹Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ²Division of Industrial Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden
Background/Purpose: Inflammatory infiltrates of muscles in polymyositis are dominated by CD4+CD28null and CD8+CD28null T cells. In contrast to conventional CD28+ T cells, these cells…
Abstract Number: 2252 • 2014 ACR/ARHP Annual Meeting
Autoimmune Thyroid Disease Is Associated with a Higher Frequency of Spinal Degenerative Disc Disease
Asha Shrestha¹, Hillel Cohen² and Clement Tagoe¹, ¹Rheumatology, Albert Einstein College of Medicine, Bronx, NY, Bronx, NY, ²Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, Bronx, NY
Background/Purpose: Autoimmune thyroid disease (AITD) has been linked to a number of rheumatic syndromes including arthritis and generalized pain. Although AITD has been associated with…
Abstract Number: 2182 • 2014 ACR/ARHP Annual Meeting
Investigating the Roles of Factor H-Related Proteins in Systemic Lupus Erythematosus (SLE) and Other Autoimmune Diseases
Alexandra Antonioli¹, Brandon Renner², Joshua Thurman³, V. Michael Holers⁴ and Jonathan Hannan⁴, ¹Department of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Renal Division, University of Colorado School of Medicine, Aurora, CO, ⁴Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose Complement plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) wherein inappropriate activation of complement leads to substantial tissue damage, especially…
Abstract Number: 1733 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Effects of Dietary Non-Digestible Oligosaccharides in T Cell-Mediated Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen², Anita Hartog³, Birgitte Walgreen⁴, Liduine van den Bersselaar¹, Monique M. Helsen¹, Paul Vos³, Johan Garssen^3,5, Linette Willemsen⁵, Wim B. van den Berg¹, Marije I. Koenders¹ and Shahla Abdollahi-Roodsaz⁶, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Nutricia Research, Utrecht, Netherlands, ⁴Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht, Netherlands, ⁶Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Accumulating evidence indicates the relevance of intestinal microbiota in shaping the immune response and supports its contribution to the development of autoimmune diseases. Prebiotic…

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