Abstracts tagged "autoimmunity and rheumatoid arthritis"

Abstract Number: 1825 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Associated Haploinsufficiency in PTPN2 Enhances Severity of IL-17 Mediated Autoimmune Arthritis
Mattias N. D. Svensson¹, Karen M. Doody², Shen Yang³, Dennis J. Wu⁴, Cristiano Sacchetti⁵, Isabelle Aubry⁶, Piotr Mydel⁷, Mitchell Kronenberg⁸, Michel L. Tremblay⁹ and Nunzio Bottini², ¹Department of Medicine, University of California San Diego, La Jolla, CA, ²Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Medicine, University of California San Diego, La Jolla, CA, ⁴University of California San Diego, San Diego, CA, ⁵Rheumatology, University of California San Diego, La Jolla, CA, ⁶Biochemistry, McGill University, Montreal, QC, Canada, ⁷University of Bergen, Bergen, Norway, ⁸Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ⁹Biochemistry, McGill University, Montréal, QC, Canada
Background/Purpose: Genetic polymorphisms at the PTPN2 locus, which encodes the tyrosine phosphatase TC-PTP, cause reduced gene expression and are linked to rheumatoid arthritis (RA). PTPN2…

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