Abstracts tagged "autoimmunity and immunoglobulin (IG)"

Abstract Number: 22 • 2018 ACR/ARHP Annual Meeting
Monoclonal Anti-Citrullinated Protein Antibodies Generated from RA-Derived B Cells Recognize Amino Acid Motifs Rather Than Specific Proteins
Johanna Steen¹, Philip J. Titcombe², Bjorn Forsström³, Caroline Grönwall⁴, Anca I. Catrina⁵, Daniel Lightwood⁶, Peter Nilsson⁷, Lars Klareskog¹ and Vivianne Malmström¹, ¹Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden, ²The Center for Immunology, Dept. of Medicine, University of Minnesota Medical School, Minneapolis, MN, ³SciLifeLab, Royal Technology Highschool,, Stockholm, Sweden, ⁴Dep. of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁵Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Antibody-discovery, UCB-Celltech, Slough, United Kingdom, ⁷Affinity Proteomics, SciLifeLab, School of Biotechnology, KTH - Royal Institute of Technology, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) develop before RA diagnosis, at which point a wide range of citrullinated proteins have been shown…

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