Abstracts tagged "autoimmunity and genetics"

Abstract Number: 1870 • 2015 ACR/ARHP Annual Meeting
A Lupus-Associated Variant in Purine Nucleoside Phosphorylase (PNP) Causes Cell Cycle Abnormalities
Yogita Ghodke-Puranik¹, Jessica M. Dorschner¹, Danielle Vsetecka¹, Shreyasee Amin², Ashima Makol³, Floranne C. Ernste², Thomas Osborn², Kevin Moder², Vaidehi Chowdhary⁴, Mark A. Jensen⁵ and Timothy B. Niewold¹, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic, Rochester, MN, ⁵Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system, autoimmune disease characterized by autoantibodies to nucleic acids and nucleosomal proteins. The type I interferon pathway is…

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Abstracts tagged "autoimmunity and genetics"

A Lupus-Associated Variant in Purine Nucleoside Phosphorylase (PNP) Causes Cell Cycle Abnormalities