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Abstracts tagged "autoimmunity and fibroblasts"

  • Abstract Number: 10 • ACR/ARHP Annual Meeting 2018

    Fibroblast like Synoviocytes (FLS) Are Capable of Inducing Phenotypical Changes Including Class Switch Recombination (CSR) in Naive B Cells, but Additional Factors Are Required to Trigger Immunoglobulin Secretion

    Dennis Bleck1, Torsten Lowin2, Matthias Schneider3 and Georg Pongratz4, 1Rheumatology Policlinic & Hiller Research Unit, Medical Faculty, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany, 2Department and Hiller Research Center for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany, 3Department and Hiller Research Center for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, 4Dpt. of Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a disease characterized by chronic inflammation of the synovial tissue in joints. It is driven by highly activated B cells.…

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