Abstracts tagged "autoimmune diseases and systemic lupus erythematosus (SLE)"

Abstract Number: 1015 • 2019 ACR/ARP Annual Meeting
Evidence for Substantial Immune Activation in Asymptomatic ANA Positive Individuals
Emma Van Lieshout¹, Dennisse Bonilla ², Zahi Touma ³, Arthur Bookman ⁴, Linda Hiraki ⁵, Zareen Ahmad ⁶, Sindhu Johnson ⁷, Earl D. Silverman ⁸ and Joan Wither ⁹, ¹University of Toronto, Toronto, ON, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, Canada, ⁴University Health Network - Toronto Western Hospital, Toronto, Canada, ⁵The Hospital for Sick Children, Toronto, Canada, ⁶Mount Sinai Hospital, Toronto, Canada, ⁷Toronto Scleroderma Program, Department of Medicine, Toronto Western and Mount Sinai Hospitals, University of Toronto, Toronto, Canada, Toronto, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁹University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Systemic autoimmune rheumatic diseases (SARD) including Sjogren’s Disease (SjD), Systemic Sclerosis (SSc) and Systemic Lupus Erythematosus (SLE) are characterized by the production of anti-nuclear…
Abstract Number: 2658 • 2017 ACR/ARHP Annual Meeting
4-Hydroxy-2-Nonenal Serum Protein-Adducts and Anti-4-Hydroxy-2-Nonenal-Protein Adduct Antibodies in SLE
Biji T Kurien^1,2,3 and R. Hal Scofield⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ³College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, complex disease and autoantibodies to self-antigens are a characteristic feature of the disorder. Our group and others…
Abstract Number: 883 • 2013 ACR/ARHP Annual Meeting
Sex Bias In Autoimmune Diseases: Increased Risk Of 47,XXX In Systemic Lupus Erythematosus (SLE) and Sjögren’s Syndrome (SS) Supports The Gene Dose Hypothesis
Ke Liu¹, Kenneth M. Kaufman^2,3, Judith A. James^4,5, Roland Jonsson^6,7, Biji T. Kurien^4,5,8, Xavier Mariette⁹, Joan T. Merrill¹⁰, Roald Omdal¹¹, Maureen Rischmueller^12,13, Timothy J. Vyse¹⁴, Marie Wahren-Herlenius¹⁵, Torsten Witte¹⁶, Christopher J. Lessard^4,5, Sarah L. Zimmerman¹⁷, Susan D. Thompson¹⁸, Gideon Hirschfield¹⁹, Gang Xie^20,21, Courtney G. Montgomery^8,22, Wan-Fai Ng²³, Gunnel Nordmark²⁴, Patrick M. Gaffney^4,8, Katherine A. Siminovitch^20,25, Kathy L. Sivils^4,26, Slegen (International Consortium For The Genetics Of SLE)²⁷ and R. Hal Scofield^4,5,28, ¹Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ²U.S. Department of Veterans Affairs Medical Center, Cincinnati, OH, ³1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁷Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ⁸U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Paris-Sud University, Paris, France, ¹⁰Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹²Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ¹³Discipline of Medicine, University of Adelaide, Adelaide, Australia, ¹⁴Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ¹⁵Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁶Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹⁷Divison of human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹⁸Division and Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁹Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²⁰Mount Sinai Hospital, Toronto, ON, Canada, ²¹University Of Toronto, Toronto, ON, Canada, ²²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²³Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ²⁴Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²⁵University of Toronto, Toronto, ON, Canada, ²⁶University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁷Center for Autoimmune Genomics and Etiology and Rheumatology Division, International Consortium For The Genetics Of Systemic Lupus Erythematosus, Cincinnati, OH, ²⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Female preponderance is a hallmark of most autoimmune diseases, the mechanism for which is unknown. We hypothesize that this is a consequence of a…