ACR Meeting Abstracts
Abstract Number: 1794 • ACR/ARHP Annual Meeting 2014
Rebecca Baum1, Jason M. Organ2, David B. Burr3, Ann Marshak-Rothstein4, Katherine A. Fitzgerald5 and Ellen M. Gravallese6, 1Cell Biology, University of Massachusetts Medical School, Worcester, MA, 2Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, 3Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, 4Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, 5Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, 6Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Cytosolic DNA sensors detect viral and bacterial DNA, inducing inflammatory cytokines and type I IFNs via the adaptor stimulator of interferon genes (STING) to…