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Abstracts tagged "autoimmune diseases and inflammation"

  • Abstract Number: 133 • 2018 ACR/ARHP Annual Meeting

    GBR830, a True OX40 Antagonist Antibody with Potent Suppressive Effects on T Cell-Mediated Pathological Responses

    Julie Macoin1, Stanislas Blein1, Thierry Monney1, Pavankumar Sancheti2, Venkateshwar Reddy3 and Jonathan Back1, 1Glenmark Pharmaceuticals SA, La Chaux-de-Fonds, Switzerland, 2Glenmark Pharmaceuticals Ltd, Mumbai, India, 3Glenmark Pharmaceuticals SA, Paramus, NJ

    Background/Purpose: OX40 (TNFRSF4, CD134) is a costimulatory receptor member of the NGFR/TNFR superfamily expressed predominantly on activated T lymphocytes. Ligation of OX40 by its ligand…
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