Abstracts tagged "autoimmune diseases and genomics"

Abstract Number: 669 • 2016 ACR/ARHP Annual Meeting
RNA-Sequencing Reveals Sjogren’s Syndrome Anti-Ro Negative Patients Share Similar Pathways to Multiple Sclerosis Patients
Indra Adrianto¹, John Ice¹, Astrid Rasmussen², Courtney Montgomery¹, R. Hal Scofield¹, Gabriel Pardo¹, Kathy Sivils¹, Robert Axtell¹ and Christopher Lessard¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease characterized by autoantibodies to Ro and/or La proteins and lymphocytic infiltration into exocrine glands. Multiple sclerosis (MS)…
Abstract Number: 987 • 2012 ACR/ARHP Annual Meeting
Autoimmune Susceptibility Genes Are Regulators of Gene Expression Response to ER Stress
William E. Bernal¹, Michael P. Morley² and Vivian G. Cheung³, ¹Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pediatrics & Genetics, Howard Hughes Medical Institute, Chevy Chase, MD; University of Pennsylvania, Philadelphia, PA
Background/Purpose: Endoplasmic recticulum (ER) stress is caused by excessive demands on the protein-processing capacity of the ER; inefficiencies in response to ER stress lead to…

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