ACR Meeting Abstracts

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Abstracts tagged "autoimmune diseases and cytokines"

  • Abstract Number: 86 • 2019 ACR/ARP Annual Meeting

    THOR-809: An IL-2 Engineered from an Expanded Genetic Alphabet for the Potential Treatment of Autoimmune Disorders

    Jerod Ptacin1, Carolina Caffaro 1, Lina Ma 1, Ingrid Joseph 1, David Chen 1, Taylor Ismaili 1, Kristine San Jose 1, Yelena Pavlova 1, Namit Singh 1, Lilia Koriazova 1, Hans Aerni 1, Michael Pena 1, Jill Mooney 1 and Marcos Milla 1, 1Synthorx, La Jolla, CA

    Background/Purpose: CD4+ regulatory T cells (Tregs) play a crucial role in maintaining immune homeostasis. Treg dysfunction is associated with multi-organ autoimmune (AI) and inflammatory-related diseases.…
  • Abstract Number: 20 • 2017 ACR/ARHP Annual Meeting

    Low Molecular Weight BAFF Receptor Antagonists Restrain Infiltration of B Cells into Organs of Autoimmune Model Mice By Suppressing B Cell Activation

    Keiko Yoshimoto1, Noriyasu Seki2, Katsuya Suzuki3, Kunio Sugahara4 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 23) Research Unit/Immunology & Inflammation, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 3Division of Rheumatology, Department of Internal Medicine, Keio University School of Medcine, Tokyo, Japan, 4Research Unit/Immunology & Inflammation, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan

    Background/Purpose: We have reported that soluble BAFF (sBAFF) robustly increased IL-6 production by peripheral monocytes of patients with primary Sjögren’s syndrome (pSS) and that the…
  • Abstract Number: 2147 • 2016 ACR/ARHP Annual Meeting

    Lack of Pro-Inflammatory Cyto/Chemokines in ANA+ Individuals with Insufficient Criteria for a Diagnosis of Systemic Autoimmune Rheumatic Disease

    Waleed Hafiz1, Nan-Hua Chang2, Babak Noamani3, Dennisse Bonilla3, Larissa Lisnevskaia4, Earl Silverman5, Arthur Bookman6, Sindhu R. Johnson7, Carolina Landolt-Marticorena3 and Joan Wither3, 1Rheumatology, University of Toronto, Toronto, ON, Canada, 2Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4Lakeridge Health Services, Oshawa, ON, Canada, 5Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 6Rheumatology, University Health Network, Toronto, ON, Canada, 7Rheumatology, Mount Sinai Hospital and University Health Network, Toronto, ON, Canada

    Background/Purpose: Patients with Systemic Autoimmune Rheumatic Disease (SARD) often have a prolonged pre-clinical phase during which they are anti-nuclear antibody (ANA) positive but lack clinical…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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