Abstracts tagged "autoantigens and vasculitis"

Abstract Number: 295 • 2017 ACR/ARHP Annual Meeting
Ex Vivo Induced Neutrophil Extracellular Traps Are Intrinsically Different in Anca-Associated Vasculitis and Systemic Lupus Erythematosus
Laura van Dam¹, Tineke Kraaij¹, Sylvia Kamerling¹, Hans U. Scherer², Charles Pusey³, Ton Rabelink¹, Cees van Kooten¹ and Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Imperial College, London, United Kingdom
- Background/Purpose: Neutrophil extracellular traps (NETs) are immunogenic, extracellular DNA structures that harness important autoantigens to be recognized by the adaptive immune system. NETs are…
Abstract Number: 1774 • 2012 ACR/ARHP Annual Meeting
Identification of Target Antigens of Anti-Endothelial Cell Antibodies in Patients with ANCA-Associated Systemic Vasculitis: A Proteomic Approach
Alexis Régent¹, Hanadi Dib², Guillaume Bussone¹, Mathieu C. Tamby¹, Nicolas Tamas², Christian Federici³, Cédric Broussard³, Loic Guillevin⁴ and Luc Mouthon¹, ¹Internal Medicine, Hopital Cochin, Paris, France, ²Université Paris Descartes, Paris, France, ³Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁴Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Anti-endothelial cell antibodies (AECA) are frequently detected in anti-neutrophil cytoplasm antibodies (ANCA)-associated systemic vasculitis (AAV) and are considered to play pathological roles but their…

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