Abstracts tagged "autoantigens and scleroderma"

Abstract Number: 661 • 2013 ACR/ARHP Annual Meeting
Topoisomerase-1 Specific T Cells Exhibit a Proinflammatory Th17 Phenotype and Are Associated With Interstitial Lung Disease In Scleroderma
Andrea Fava¹, Raffaello Cimbro¹, Antony Rosen², Qing-Rong Liu³, Fredrick M. Wigley² and Francesco Boin², ¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³NIH/NIDA, Baltimore, MD
Background/Purpose: Anti-topoisomerase-1 (Topo-1 or Scl70) autoantibodies are present in 30-45% of scleroderma (SSc) patients and identify a more aggressive disease phenotype with worse clinical outcome…

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Abstracts tagged "autoantigens and scleroderma"

Topoisomerase-1 Specific T Cells Exhibit a Proinflammatory Th17 Phenotype and Are Associated With Interstitial Lung Disease In Scleroderma