Abstracts tagged "autoantigens and autoimmunity"

Abstract Number: 984 • 2014 ACR/ARHP Annual Meeting
Apolipoprotein B Is a Target of T and B Cell Responses in a Subgroup of Patients with Lyme Disease
Jameson T. Crowley¹, Elise E. Drouin², Qi Wang³, Gail McHugh⁴, Catherine E. Costello³ and Allen C. Steere⁵, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁴Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose Borrelia burgdorferi-induced autoimmunity in affected joints has been hypothesized to be a contributing factor to antibiotic-refractory Lyme arthritis (ARLA). Our prior study, which combined…
Abstract Number: 923 • 2013 ACR/ARHP Annual Meeting
Redox Dependent Conformational Changes Of The Autoantigen La Are Responsible For Its Shuttling, Translocation and a Pathophysiological Role Of Anti-La Autoantibodies
Irene Michalk¹, Nicole Berndt¹, Claudia C. Bippes¹, Holger Bartsch², Stefanie Koristka³, Claudia Arndt¹, Anja Feldmann¹, Biji T. Kurien⁴, Robert Hal Scofield⁵, A. Darise Farris⁶, Judith A. James⁷, Marc Cartellieri¹ and Michael Bachmann¹, ¹Inst. Immunology, Carl Gustav Carus TU-Dresden, Dresden, Germany, ²Inst. Immunol., Carl Gustav Carus TU-Dresden, Dresden, Germany, ³Carl Gustav Carus TU-Dresden, Dresden, Germany, ⁴College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁶Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁷Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Since their detection a pathophysiological role of antibodies (abs) to extractable nuclear autoantigens including anti-La abs has been controversially discussed. Stainings of anti-La abs…