Abstracts tagged "Autoantibodies and systemic sclerosis"

Abstract Number: 802 • 2018 ACR/ARHP Annual Meeting
Prognostic Significance of Bicaudal D2 Antibodies in Sistemic Sclerosis (SSc) Patients
Giulia Segatto¹, Chiara Bellocchi², Gaia Montanelli¹, Silvia Casas³, Karl Norvell⁴, Michelle Amino³, Fabrece Roup⁴, Michael Mahler⁴ and Lorenzo Beretta², ¹Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milano, Italy, ²Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ³Inova Diagnostics, San Diego, CA, ⁴Research and Development, Inova Diagnostics, San Diego, CA
Background/Purpose: Antibodies (Ab) toward Bicaudal D homolog 2 (BlCD2) can be found in 25% of Systemic Sclerosis (SSc) sera, mostly in association with anti-centromere (ACA)…
Abstract Number: 747 • 2017 ACR/ARHP Annual Meeting
Autoantibodies to Rpp25 (Th/To) Are Specific Markers for Systemic Sclerosis and Are Associated with Limited Cutaneous Disease and Young Age at Disease Onset
Boyang Zheng¹, Martial Koenig², Marychel Tiongson³, Andrea Seaman³, Danilo Villalta⁴, Gabriella Morozzi⁵, Nicola Bizzaro⁶, Gabriella Pucci⁷, Michaelin Richards³ and Michael Mahler³, ¹Division of Internal Medicine, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada, ²Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ³Research and Development, Inova Diagnostics, San Diego, CA, ⁴Allergologia e Immunologia Clinica, AO S. Maria degli Angeli, Pordenone, Pordenone, Italy, ⁵Chirurgiche e Neuroscienze, Sezione di Reumatologia, Università di Siena, Dipartimento Scienze Mediche, Siena, Italy, ⁶Ospedale San Antonio, Tolmezzo, Italy, ⁷Chirurgiche e Neuroscienze, Sezione di Reumatologia, Università di Siena, Siena, Italy
Autoantibodies to Rpp25 (Th/To) are specific markers for systemic sclerosis and are associated with limited cutaneous disease and young age at disease onset[MM1] Boyang Zheng4, Martial…
Abstract Number: 1712 • 2014 ACR/ARHP Annual Meeting
Monocytic Angiotensin and Endothelin Receptor Imbalance Determines Secretion of the Profibrotic Chemokine Ligand CCL18
Judith Rademacher¹, Jeannine Guenther², Angela Kill³, Elise Siegert⁴ and Gabriela Riemekasten⁵, ¹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, 10117 Berlin, Germany, ²Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, ³Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ⁵Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose Circulating monocytes are progrenitor of extra-cellular matrix producing cells involved in fibrosis and show highest expression of angiotensin II (ATR) and endothelin receptors (ETR)…
Abstract Number: 1748 • 2013 ACR/ARHP Annual Meeting
Autoantibodies To RuvBL1 and RuvBL2: A Novel Systemic Sclerosis-Related Antibody Associated With Diffuse Cutaneous and Skeletal Muscle Involvement
Kenzo Kaji¹, Noreen Fertig², Thomas A. Medsger Jr.³, Takashi Sathoh⁴, Kana Hoshino⁴, Yasuhito Hamaguchi¹, Minoru Hasegawa⁵, Mary Lucas⁶, Andrew Schnure⁶, Fumihide Ogawa⁷, Shinichi Sato⁸, Kazuhiko Takehara⁹, Manabu Fujimoto⁵ and Masataka Kuwana⁴, ¹Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ²University of Pittsburgh, Pittsburgh, PA, ³Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁵Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan, ⁶Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁷Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁸Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan, ⁹Dermatology, Kanazawa University, Kanazawa, Japan
Background/Purpose: Detection of serum autoantibodies is useful in diagnosis, disease subgrouping, and prediction of subsequent organ involvement and prognosis in patients with systemic sclerosis (SSc).…
Abstract Number: 705 • 2013 ACR/ARHP Annual Meeting
Treatment With Rituximab Reduces Activation Of Scleroderma Dermal Fibroblasts
Paolo Fraticelli¹, Salvatore De Vita², Nicoletta Franzolini³, Silvia Svegliati⁴, Cecilia Tonnini⁴, Barbara Gabrielli⁵, Cathryn Anne Scott⁶, Giovanni Pomponio⁷, Gianluca Moroncini⁴ and Armando Gabrielli⁴, ¹Istituto di Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ²Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, ³Presidio Ospedaliero di San Daniele del Friuli, ASS 4 “Medio Friuli, Udine, Italy, ⁴Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy, ⁵Università Politecnica delle Marche, Ancona, Italy, ⁶Department of Medical and Biological Sciences, Università degli studi di Udine ·, Udine, Italy, ⁷Medicina Interna, Ospedali Riuniti, Ancona, Italy
Background/Purpose: There is evidence that B lymphocytes play a role in the pathogenesis of systemic sclerosis (scleroderma). Stimulatory autoantibodies targeting PDGF receptor and activating normal…
Abstract Number: 714 • 2012 ACR/ARHP Annual Meeting
Line Blot Assay, a Screening Test for Autoantibodies in Systemic Sclerosis (SSc)
Kae Takagi¹, Yasushi Kawaguchi¹, Sayuri Kataoka¹, Yuko Ota², Yuko Okamoto¹, Masanori Hanaoka¹, Hisae Ichida¹, Takahisa Gono¹, Yasuhiro Katsumata¹ and Hisashi Yamanaka¹, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology,Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Detection of auto-antibody is informative for diagnosis of SSc. Line blot assay (LBA) provides a quantitative in vitro assay for detecting human IgG class…