Abstracts tagged "autoantibodies and systemic lupus erythematosus (SLE)"

Abstract Number: 1402 • 2012 ACR/ARHP Annual Meeting
Anti-ApoA1 Antibodies Associate with Disease Activity in Lupus and Are Lower in Patients Taking Hydroxychloroquine: A Longitudinal Analysis of 398 Samples
Sara Croca¹, Ian Giles², David A. Isenberg³, Yiannis Ioannou⁴ and Anisur Rahman², ¹Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ²Centre for Rheumatology Research,Rayne Institute, 4th Floor, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of developing cardiovascular disease. The presence of chronic inflammation which characterizes SLE…
Abstract Number: 672 • 2012 ACR/ARHP Annual Meeting
Immune Complexes and Autoantibodies to Oxidized Lipids in Systemic Lupus Erythematosus
Yujin Ye¹, Tianfu Wu¹ and Chandra Mohan², ¹Division of Rheumatology/Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, Dallas, TX, ²University of Houston, Houston, TX
Background/Purpose: SLE is a chronic autoimmune inflammatory disease. Increasing evidence suggest that excess production of reactive oxygen species (ROS) may cause oxidative stress and favor…
Abstract Number: 677 • 2012 ACR/ARHP Annual Meeting
Antibodies to Oxidized Low Density Lipoprotein or Anti-Lipoprotein Lipase May Lead to More Atherosclerotic Plaque in a Sub-Set of SLE Patients
Biji T. Kurien¹, James Fesmire², Skyler P. Dillon³, Marianne Reichlin⁴, Morris Reichlin⁵ and Robert H. Scofield⁶, ¹College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, ³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Oklahoma Medical Res Fndn, Oklahoma City, OK, ⁵Arthritis & Imm Laboratory, Oklahoma Medical Research Foun, Oklahoma City, OK, ⁶Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). Oxidized low density lipoproteins (oxLDL) are important in atherosclerosis and have been reported in SLE…
Abstract Number: 659 • 2012 ACR/ARHP Annual Meeting
The Small Molecule Activator to ACE2 Prevents the Inhibition of ACE2 Activity by Autoantibodies
Shiori Haga¹, Yuko Takahashi², Yukihito Ishizaka¹ and Akio Mimori², ¹Department of Intractable Diseases, National Center for Global Health and Medicine, Research Institute, Tokyo, Japan, ²Division of Rheumatic Diseases, National Center for Global Health and Medicine, Tokyo, Japan
Background/Purpose: Angiotensin-converting enzyme 2 (ACE2) is a member of renin-angiotensin system that plays a critical role in regulating blood pressure and cardiovascular function. It is…

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