Abstracts tagged "autoantibodies and systemic lupus erythematosus (SLE)"

Abstract Number: 2313 • 2012 ACR/ARHP Annual Meeting
The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Belongs to CCR4⁺CD45RB^lo122^lo CD4 Subpopulation: A Novel ‘Self-Organized Criticality Theory’ Explains the Cause of Systemic Lupus Erythematosus (SLE)
Yumi Miyazaki¹, Ken Tsumiyama² and Shunichi Shiozawa², ¹Kyushu University Beppu Hospital/ Kobe University Graduate School of Health Sciences, Beppu/ Kobe, Japan, ²Kyushu University Beppu Hospital, Beppu, Japan
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…
Abstract Number: 1725 • 2012 ACR/ARHP Annual Meeting
ANTI-Factor Xa Antibodies ARE Significantly Increased in Patients with Systemic LUPUS Erythematosus and Antiphospholipid Syndrome
Bahar Artim-Esen¹, Charis Pericleous², Ian Mackie³, Yiannis Ioannou⁴, Anisur Rahman⁵, David A. Isenberg⁶ and Ian Giles⁵, ¹Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ³Haemostasis Research Unit, 1st Floor, 51 Chenies Mews, Haemostasis Research Unit, University College London, London, United Kingdom, ⁴Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁵Centre for Rheumatology Research,Rayne Institute, 4th Floor, University College London, London, United Kingdom, ⁶Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom
Background/Purpose: Increased levels of antibodies against different serine proteases (SP) have been identified in patients with the Antiphospholipid Syndrome (APS) compared with healthy controls. These…
Abstract Number: 1450 • 2012 ACR/ARHP Annual Meeting
MEDI-551 Depletes a Majority of Murine B Cells and Reduces Serum Titers of Autoantibodies in the SLE1-huCD19 TG Mice
Sandra Gallagher¹, Yue Wang¹, Isharat Yusuf¹, Thomas McCaughtry¹, Ronald Herbst² and Laura Carter¹, ¹Respiratory, Inflammation and Autoimmune, MedImmune, Gaithersburg, MD, ²Respiration, Inflammation and Autoimmunity, MedImmune, Gaithersburg, MD
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation that can affect various organs. Hyperactive B cells appear to be key drivers in SLE…
Abstract Number: 1422 • 2012 ACR/ARHP Annual Meeting
Clinical Associations of Anti-Smith Antibodies in Profile: A Multiethnic Lupus Cohort
Yesenia C. Santiago-Casas¹, Luis M. Vila¹, Gerald McGwin Jr.², Ryan S. Cantor², Michelle Petri³, Rosalind Ramsey-Goldman⁴, John D. Reveille⁵, Robert P. Kimberly⁶, Graciela S. Alarcon⁷ and Elizabeth E. Brown⁸, ¹Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ²Epidemiology, University of Alabama at Birmingham, Birmingham, AL, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁶Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁸University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Anti-Smith (anti-Sm) antibodies are highly specific for systemic lupus erythematosus (SLE) and have an important value in the diagnosis of this disease. However, whether…

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