Abstract Number: 3 • 2018 ACR/ARHP Annual Meeting
Interferon-Alpha Disrupts DNA-Specific B Cell Tolerance in 3H9 Mice
Background/Purpose: A central mediator of Systemic Lupus Erythematosus (SLE) pathogenesis is interferon-alpha (IFNα), which is elevated in the serum of SLE patients. IFNα has been…Abstract Number: 2655 • 2018 ACR/ARHP Annual Meeting
SLE-Key® Ruleout Testing in Support of Patient Triage in the Clinical Rheumatology Setting
Background/Purpose: SLE diagnosis and classification can be challenging. The low incidence of SLE limits primary care physician experience with the disease, but the impact of…Abstract Number: 1833 • 2016 ACR/ARHP Annual Meeting
Autoantibody Response to TROVE2 in Systemic LUPUS Erythematosus Patients
Background/Purpose: Ro60/TROVE2 is a clinically important member of the nuclear antigen family. It binds synergistically YRNAs, allowing the formation of a stable complex with exoribonuclease…Abstract Number: 1953 • 2014 ACR/ARHP Annual Meeting
Circulating Plasmablasts from Patients with Systemic Lupus Erythematosus Produce Autoantibodies Reactive to Epstein-Barr Virus
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by the over-production of high affinity autoantibodies. It is not clear how such autoantibodies are generated during the…Abstract Number: 622 • 2013 ACR/ARHP Annual Meeting
Serum Anti-Apolipoprotein 1 Antibodies Are Present In a Quarter Of Patients With Systemic Lupus Erythematosus At The Time Of Diagnosis and Are Associated With Earlier Mortality
Background/Purpose: A large number of different autoantibodies have been reported in patients with systemic lupus erythematosus but not all have been related to clinical outcomes.…Abstract Number: 632 • 2013 ACR/ARHP Annual Meeting
Anti-Ribosomal-Phosphoprotein Autoantibodies Penetrate Into Neuronal Cells Via Neuron Growth Associated Protein (GAP43)
Background/Purpose: Autoantibodies targeting ribosomal phosphoproteins (anti-Ribos.P) are detected in the sera of 10-45% patients with neuropsychiatric-systemice-lupus-erythemathosus-(NPSLE) and correlate with disease-activity. Intracerebroventricular administration of anti-Ribos.P induce…Abstract Number: 547 • 2013 ACR/ARHP Annual Meeting
Anti Ribosomal P Antibodies Accelerate Lupus Glomerulonephritis and Induce Lupus Nephritis In Naive Mice
Background/Purpose: Circulating anti-phosphoribosomal protein antibodies (anti-Ribos.P) were found to be associated with lupus nephritis. We have assessed the direct role of anti-Ribos.P in the development…Abstract Number: 2535 • 2013 ACR/ARHP Annual Meeting
Rare Autoantibodies To Cellular Antigens In Systemic Lupus Erythematosous
Background/Purpose: a high number of antinuclear antibody specificities can be detected in Systemic Lupus Erythematosous (SLE). Some of them are related to a distinct clinical…Abstract Number: 1648 • 2013 ACR/ARHP Annual Meeting
PD-1+CD45RBlo122lo Autoantibody-Inducing CD4 T Cells (aiCD4 T cells) As a Key In The Pathogenesis Of Systemic Lupus Erythematosus (SLE)
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…Abstract Number: 1638 • 2013 ACR/ARHP Annual Meeting
Concurrent Autoimmune Disease and Autoantibodies In a Large, Multi-Racial Cohort Of First Degree Blood Relatives Of SLE Patients
Background/Purpose: First degree relatives (FDRs) of SLE patients have an increased risk of developing autoantibodies and/or autoimmune disorders. Between 20% and 40% of FDRs develop…Abstract Number: 2313 • 2012 ACR/ARHP Annual Meeting
The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Belongs to CCR4+CD45RBlo122lo CD4 Subpopulation: A Novel ‘Self-Organized Criticality Theory’ Explains the Cause of Systemic Lupus Erythematosus (SLE)
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…Abstract Number: 1725 • 2012 ACR/ARHP Annual Meeting
ANTI-Factor Xa Antibodies ARE Significantly Increased in Patients with Systemic LUPUS Erythematosus and Antiphospholipid Syndrome
Background/Purpose: Increased levels of antibodies against different serine proteases (SP) have been identified in patients with the Antiphospholipid Syndrome (APS) compared with healthy controls. These…Abstract Number: 1450 • 2012 ACR/ARHP Annual Meeting
MEDI-551 Depletes a Majority of Murine B Cells and Reduces Serum Titers of Autoantibodies in the SLE1-huCD19 TG Mice
Background/Purpose: Systemic Lupus Erythematosus (SLE) is characterized by chronic inflammation that can affect various organs. Hyperactive B cells appear to be key drivers in SLE…Abstract Number: 1422 • 2012 ACR/ARHP Annual Meeting
Clinical Associations of Anti-Smith Antibodies in Profile: A Multiethnic Lupus Cohort
Background/Purpose: Anti-Smith (anti-Sm) antibodies are highly specific for systemic lupus erythematosus (SLE) and have an important value in the diagnosis of this disease. However, whether…Abstract Number: 1402 • 2012 ACR/ARHP Annual Meeting
Anti-ApoA1 Antibodies Associate with Disease Activity in Lupus and Are Lower in Patients Taking Hydroxychloroquine: A Longitudinal Analysis of 398 Samples
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of developing cardiovascular disease. The presence of chronic inflammation which characterizes SLE…
ACR Meeting Abstracts