Abstract Number: 3 • 2018 ACR/ARHP Annual Meeting
Interferon-Alpha Disrupts DNA-Specific B Cell Tolerance in 3H9 Mice
Background/Purpose: A central mediator of Systemic Lupus Erythematosus (SLE) pathogenesis is interferon-alpha (IFNα), which is elevated in the serum of SLE patients. IFNα has been…Abstract Number: 2655 • 2018 ACR/ARHP Annual Meeting
SLE-Key® Ruleout Testing in Support of Patient Triage in the Clinical Rheumatology Setting
Background/Purpose: SLE diagnosis and classification can be challenging. The low incidence of SLE limits primary care physician experience with the disease, but the impact of…Abstract Number: 1833 • 2016 ACR/ARHP Annual Meeting
Autoantibody Response to TROVE2 in Systemic LUPUS Erythematosus Patients
Background/Purpose: Ro60/TROVE2 is a clinically important member of the nuclear antigen family. It binds synergistically YRNAs, allowing the formation of a stable complex with exoribonuclease…Abstract Number: 1953 • 2014 ACR/ARHP Annual Meeting
Circulating Plasmablasts from Patients with Systemic Lupus Erythematosus Produce Autoantibodies Reactive to Epstein-Barr Virus
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by the over-production of high affinity autoantibodies. It is not clear how such autoantibodies are generated during the…Abstract Number: 2535 • 2013 ACR/ARHP Annual Meeting
Rare Autoantibodies To Cellular Antigens In Systemic Lupus Erythematosous
Background/Purpose: a high number of antinuclear antibody specificities can be detected in Systemic Lupus Erythematosous (SLE). Some of them are related to a distinct clinical…Abstract Number: 1648 • 2013 ACR/ARHP Annual Meeting
PD-1+CD45RBlo122lo Autoantibody-Inducing CD4 T Cells (aiCD4 T cells) As a Key In The Pathogenesis Of Systemic Lupus Erythematosus (SLE)
Background/Purpose: We found that systemic lupus erythematosus (SLE) was induced experimentally by repeatedly immunizing the mice normally not prone to autoimmune diseases by any exogenous…Abstract Number: 1638 • 2013 ACR/ARHP Annual Meeting
Concurrent Autoimmune Disease and Autoantibodies In a Large, Multi-Racial Cohort Of First Degree Blood Relatives Of SLE Patients
Background/Purpose: First degree relatives (FDRs) of SLE patients have an increased risk of developing autoantibodies and/or autoimmune disorders. Between 20% and 40% of FDRs develop…Abstract Number: 622 • 2013 ACR/ARHP Annual Meeting
Serum Anti-Apolipoprotein 1 Antibodies Are Present In a Quarter Of Patients With Systemic Lupus Erythematosus At The Time Of Diagnosis and Are Associated With Earlier Mortality
Background/Purpose: A large number of different autoantibodies have been reported in patients with systemic lupus erythematosus but not all have been related to clinical outcomes.…Abstract Number: 632 • 2013 ACR/ARHP Annual Meeting
Anti-Ribosomal-Phosphoprotein Autoantibodies Penetrate Into Neuronal Cells Via Neuron Growth Associated Protein (GAP43)
Background/Purpose: Autoantibodies targeting ribosomal phosphoproteins (anti-Ribos.P) are detected in the sera of 10-45% patients with neuropsychiatric-systemice-lupus-erythemathosus-(NPSLE) and correlate with disease-activity. Intracerebroventricular administration of anti-Ribos.P induce…Abstract Number: 547 • 2013 ACR/ARHP Annual Meeting
Anti Ribosomal P Antibodies Accelerate Lupus Glomerulonephritis and Induce Lupus Nephritis In Naive Mice
Background/Purpose: Circulating anti-phosphoribosomal protein antibodies (anti-Ribos.P) were found to be associated with lupus nephritis. We have assessed the direct role of anti-Ribos.P in the development…Abstract Number: 1402 • 2012 ACR/ARHP Annual Meeting
Anti-ApoA1 Antibodies Associate with Disease Activity in Lupus and Are Lower in Patients Taking Hydroxychloroquine: A Longitudinal Analysis of 398 Samples
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of developing cardiovascular disease. The presence of chronic inflammation which characterizes SLE…Abstract Number: 672 • 2012 ACR/ARHP Annual Meeting
Immune Complexes and Autoantibodies to Oxidized Lipids in Systemic Lupus Erythematosus
Background/Purpose: SLE is a chronic autoimmune inflammatory disease. Increasing evidence suggest that excess production of reactive oxygen species (ROS) may cause oxidative stress and favor…Abstract Number: 677 • 2012 ACR/ARHP Annual Meeting
Antibodies to Oxidized Low Density Lipoprotein or Anti-Lipoprotein Lipase May Lead to More Atherosclerotic Plaque in a Sub-Set of SLE Patients
Background/Purpose: Premature atherosclerosis is associated with systemic lupus erythematosus (SLE). Oxidized low density lipoproteins (oxLDL) are important in atherosclerosis and have been reported in SLE…Abstract Number: 659 • 2012 ACR/ARHP Annual Meeting
The Small Molecule Activator to ACE2 Prevents the Inhibition of ACE2 Activity by Autoantibodies
Background/Purpose: Angiotensin-converting enzyme 2 (ACE2) is a member of renin-angiotensin system that plays a critical role in regulating blood pressure and cardiovascular function. It is…Abstract Number: 670 • 2012 ACR/ARHP Annual Meeting
Prolidase Deficiency Induces Antibodies to Sm, Ro60 and Double Stranded DNA
Background/Purpose: Prolidase is a ubiquitous enzyme found in the cytoplasm. The enzyme specifically cleaves dipeptides containing C-terminal proline or hydroxyproline, in one of the last…
ACR Meeting Abstracts