Abstracts tagged "autoantibodies and rheumatoid arthritis (RA)"

Abstract Number: 3103 • 2015 ACR/ARHP Annual Meeting
Carbamylated Human Albumin Is One of the Target Antigens of Anti-Carbamylated Protein Antibodies
Shuichiro Nakabo¹, Koichiro Ohmura¹, Kosaku Murakami¹, Ran Nakashima¹, Moritoshi Furu², Masahiro Ishikawa², Motomu Hashimoto², Yoshitaka Imura¹, Naoichiro Yukawa¹, Hajime Yoshifuji¹, Hiromu Ito², Takao Fujii² and Tsuneyo Mimori^1,2, ¹Department of Rheumatology and Clinical Immunology, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Department of the Control for Rheumatic Diseases, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: Anti-carbamylated protein antibody (anti-CarP) is seen in 45% of rheumatoid arthritis (RA) patients [1]. The precise target antigen (Ag) of anti-CarP had not been…
Abstract Number: 3154 • 2015 ACR/ARHP Annual Meeting
The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies
Elisa Corsiero¹, Emanuela Carlotti², Costantino Pitzalis³ and Michele Bombardieri⁴, ¹WHRI - EMR, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ³Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, ⁴Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom
Background/Purpose: We previously showed that anti-citrullinated peptide/protein antibodies (ACPA) targeting citrullinated antigens contained in neutrophils extracellular traps (NETs) can be manufactured within ectopic germinal center-like…
Abstract Number: 446 • 2014 ACR/ARHP Annual Meeting
Immunoglobulin a Antibodies to Cyclic Citrullinated Protein Predominate in Individuals at-Risk for Future Rheumatoid Arthritis
Gregory M. Ingolia¹, M. Kristen Demoruelle², Mark C. Parish², Ryan W. Gan³, Jason R. Kolfenbach², Michael H. Weisman⁴, Jane H. Buckner⁵, Peter K. Gregersen⁶, Ted R. Mikuls⁷, James R. O'Dell⁸, Richard M. Keating⁹, Alvin Yee¹⁰, Michael Mahler¹⁰, Jill M. Norris³, Kevin D. Deane² and V. Michael Holers¹¹, ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Epidemiology, Colorado School of Public Health, Aurora, CO, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, ⁷University of Nebraska Medical Center, Omaha, NE, ⁸Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁹Division of Rheumatology, Scripps Clinic, La Jolla, CA, ¹⁰Research, INOVA Diagnostics, San Diego, CA, ¹¹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose Immunoglobulin A (IgA) autoantibodies (Abs) to citrullinated proteins (ACPAs) are present in the preclinical period of RA development, a finding that suggests a mucosal…
Abstract Number: 357 • 2014 ACR/ARHP Annual Meeting
Development and Validation of a Diagnostic Bead-Based Multiplex Autoantibody Assay:Screening for Autoantibodies to Detect “Seronegative” Rheumatoid Arthritis
Stefan Vordenbäumen¹, Angelika Lueking², Carmen Theek², Ralph Brinks¹, Rebecca Fischer-Betz¹, Jutta Richter¹, Ellen Bleck¹, Jacqueline Detert³, Gerd Burmester⁴, Peter Schulz-Knappe² and Matthias Schneider¹, ¹Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, ²Protagen AG, Dortmund, Germany, ³Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, ⁴Departement of Rhe, University Medicine, Berlin, Germany
Background/Purpose: Autoantibodies (auto-Ab) against citrullinated peptides (ACPA) and rheumatoid factor (RF) are important biomarkers in the diagnostic process of rheumatoid arthritis (RA). However, RF or…
Abstract Number: 912 • 2013 ACR/ARHP Annual Meeting
B-Cell Responses To De Novo Identified Citrullinated Fibrinogen Peptides Are Associated With PTPN22 Risk Allele
Vijay Joshua¹, Loes Schobers², Lena Israelsson³, Johan Rönnelid⁴, Monika Hansson⁵, Anca I Catrina⁶, Ger JM Pruijn² and Vivianne Malmström⁷, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Department of Biomolecular Chemistry, Radboud University, Nijmegen, Netherlands, ³Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ⁴Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ⁵Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ⁶Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁷Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Antibodies against citrullinated proteins are common in patients with rheumatoid arthritis (RA) and appear prior to the onset of the disease [1]. Many of…
Abstract Number: 869 • 2013 ACR/ARHP Annual Meeting
Anti-Carbamylated Protein Antibodies Are Present Prior To The Diagnosis Of Rheumatoid Arthritis and Predict Future Disease Onset
Ryan W. Gan¹, Leendert A. Trouw², Jing Shi², René E.M. Toes², Tom W. J. Huizinga², Gary O. Zerbe³, Kevin D. Deane⁴, Jess Edison⁵, William R. Gilliland⁶, Jill M. Norris¹ and V. Michael Holers⁷, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁴Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁵Department of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, ⁶Walter Reed National Military Medical Center, Bethesda, MD, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Anti-cyclic citrullinated peptide-2 (CCP2) can be present in serum years before a diagnosis of rheumatoid arthritis (RA), and is highly specific (>95%) for the…
Abstract Number: 2302 • 2013 ACR/ARHP Annual Meeting
Anti-Carbamylated Protein Antibody In Japanese Patients With Rheumatoid Arthritis
Shunichi Shiozawa¹, Leendert A. Trouw² and Kazuko Shiozawa³, ¹Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³The Rheumatic Diseases Center, Konan Kakogawa Hospital, Kakogawa, Japan
Background/Purpose: Serology represents a powerful tool for the identification and sub-classification of patients with rheumatoid arthritis (RA). IgM-rheumatoid factor and anti-cyclic citrullinated peptide (CCP) antibodies…
Abstract Number: 909 • 2013 ACR/ARHP Annual Meeting
Diagnostic Autoantibody Signatures Of Rheumatoid Arthritis Patients Identified With a Bead-Based Assay Approach
Angelika Lueking¹, Petra Budde¹, Stefan Vordenbäumen², Carmen Theek¹, Heike Goehler¹, Martin Gamer¹, Peter Schulz-Knappe¹ and Matthias Schneider³, ¹Protagen AG, Dortmund, Germany, ²Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, ³Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease typically characterized by chronic inflammation, accumulation of self-reactive B-cells and production of autoantibodies of which anti–cyclic citrullinated…
Abstract Number: 1771 • 2012 ACR/ARHP Annual Meeting
Anti Carbamylated Protein Antibodies (Anti-CarP) Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis
Jing Shi¹, Lotte van de Stadt², Nivine Levarht³, T.W.J. Huizinga⁴, R. E. M. Toes⁴, Leendert A. Trouw⁵ and Dirkjan van Schaardenburg², ¹Rheumatology, LUMC, Leiden, Netherlands, ²Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Recently, we discovered a new autoantibody system in rheumatoid arthritis (RA): anti carbamylated protein antibodies (anti-CarP). These antibodies have additional prognostic value in predicting…
Abstract Number: 1194 • 2012 ACR/ARHP Annual Meeting
Prevalence of Anti-Peptidylarginine Deiminase Type 4 Antibodies in Rheumatoid Arthritis and Unaffected First-Degree Relatives in Indigenous North American Populations
Elizabeth D. Ferucci¹, Irene Smolik², Tammy L. Choromanski³, David B. Robinson⁴, Marianna M. Newkirk⁵, Marvin J. Fritzler⁶, Antony Rosen⁷, Erika Darrah⁸ and Hani S. El-Gabalawy⁴, ¹Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, ²Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, ³Alaska Native Tribal Health Consortium, Anchorage, AK, ⁴Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, ⁵Medicine, McGill University Health Centr, Montreal, QC, Canada, ⁶Medicine, University of Calgary, Calgary, AB, Canada, ⁷Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁸Division of Rheumatology, The Johns Hopkins University, Baltimore, MD
Background/Purpose: Antibodies directed against peptidylarginine deiminase type 4 (PAD-4) are present in a subset of patients with rheumatoid arthritis (RA) and are associated with more…

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