ACR Meeting Abstracts

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Abstracts tagged "autoantibodies and rheumatoid arthritis (RA)"

  • Abstract Number: 3103 • 2015 ACR/ARHP Annual Meeting

    Carbamylated Human Albumin Is One of the Target Antigens of Anti-Carbamylated Protein Antibodies

    Shuichiro Nakabo1, Koichiro Ohmura1, Kosaku Murakami1, Ran Nakashima1, Moritoshi Furu2, Masahiro Ishikawa2, Motomu Hashimoto2, Yoshitaka Imura1, Naoichiro Yukawa1, Hajime Yoshifuji1, Hiromu Ito2, Takao Fujii2 and Tsuneyo Mimori1,2, 1Department of Rheumatology and Clinical Immunology, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Department of the Control for Rheumatic Diseases, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Background/Purpose: Anti-carbamylated protein antibody (anti-CarP) is seen in 45% of rheumatoid arthritis (RA) patients [1]. The precise target antigen (Ag) of anti-CarP had not been…
  • Abstract Number: 3154 • 2015 ACR/ARHP Annual Meeting

    The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies

    Elisa Corsiero1, Emanuela Carlotti2, Costantino Pitzalis3 and Michele Bombardieri4, 1WHRI - EMR, London, United Kingdom, 2Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, 3Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, 4Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom

    Background/Purpose: We previously showed that anti-citrullinated peptide/protein antibodies (ACPA) targeting citrullinated antigens contained in neutrophils extracellular traps (NETs) can be manufactured within ectopic germinal center-like…
  • Abstract Number: 446 • 2014 ACR/ARHP Annual Meeting

    Immunoglobulin a Antibodies to Cyclic Citrullinated Protein Predominate in Individuals at-Risk for Future Rheumatoid Arthritis

    Gregory M. Ingolia1, M. Kristen Demoruelle2, Mark C. Parish2, Ryan W. Gan3, Jason R. Kolfenbach2, Michael H. Weisman4, Jane H. Buckner5, Peter K. Gregersen6, Ted R. Mikuls7, James R. O'Dell8, Richard M. Keating9, Alvin Yee10, Michael Mahler10, Jill M. Norris3, Kevin D. Deane2 and V. Michael Holers11, 1University of Colorado School of Medicine, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Epidemiology, Colorado School of Public Health, Aurora, CO, 4Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 5Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, 7University of Nebraska Medical Center, Omaha, NE, 8Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 9Division of Rheumatology, Scripps Clinic, La Jolla, CA, 10Research, INOVA Diagnostics, San Diego, CA, 11Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose Immunoglobulin A (IgA) autoantibodies (Abs) to citrullinated proteins (ACPAs) are present in the preclinical period of RA development, a finding that suggests a mucosal…
  • Abstract Number: 357 • 2014 ACR/ARHP Annual Meeting

    Development and Validation of a Diagnostic Bead-Based Multiplex Autoantibody Assay:Screening for Autoantibodies to Detect “Seronegative” Rheumatoid Arthritis

    Stefan Vordenbäumen1, Angelika Lueking2, Carmen Theek2, Ralph Brinks1, Rebecca Fischer-Betz1, Jutta Richter1, Ellen Bleck1, Jacqueline Detert3, Gerd Burmester4, Peter Schulz-Knappe2 and Matthias Schneider1, 1Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, 2Protagen AG, Dortmund, Germany, 3Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 4Departement of Rhe, University Medicine, Berlin, Germany

    Background/Purpose: Autoantibodies (auto-Ab) against citrullinated peptides (ACPA) and rheumatoid factor (RF) are important biomarkers in the diagnostic process of rheumatoid arthritis (RA). However, RF or…
  • Abstract Number: 2302 • 2013 ACR/ARHP Annual Meeting

    Anti-Carbamylated Protein Antibody In Japanese Patients With Rheumatoid Arthritis

    Shunichi Shiozawa1, Leendert A. Trouw2 and Kazuko Shiozawa3, 1Department of Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3The Rheumatic Diseases Center, Konan Kakogawa Hospital, Kakogawa, Japan

    Background/Purpose: Serology represents a powerful tool for the identification and sub-classification of patients with rheumatoid arthritis (RA). IgM-rheumatoid factor and anti-cyclic citrullinated peptide (CCP) antibodies…
  • Abstract Number: 909 • 2013 ACR/ARHP Annual Meeting

    Diagnostic Autoantibody Signatures Of Rheumatoid Arthritis Patients Identified With a Bead-Based Assay Approach

    Angelika Lueking1, Petra Budde1, Stefan Vordenbäumen2, Carmen Theek1, Heike Goehler1, Martin Gamer1, Peter Schulz-Knappe1 and Matthias Schneider3, 1Protagen AG, Dortmund, Germany, 2Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, 3Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease typically characterized by chronic inflammation, accumulation of self-reactive B-cells and production of autoantibodies of which anti–cyclic citrullinated…
  • Abstract Number: 912 • 2013 ACR/ARHP Annual Meeting

    B-Cell Responses To De Novo Identified Citrullinated Fibrinogen Peptides Are Associated With PTPN22 Risk Allele

    Vijay Joshua1, Loes Schobers2, Lena Israelsson3, Johan Rönnelid4, Monika Hansson5, Anca I Catrina6, Ger JM Pruijn2 and Vivianne Malmström7, 1Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 2Department of Biomolecular Chemistry, Radboud University, Nijmegen, Netherlands, 3Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, 4Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, 5Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6Rheumatology Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden, 7Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Antibodies against citrullinated proteins are common in patients with rheumatoid arthritis (RA) and appear prior to the onset of the disease [1]. Many of…
  • Abstract Number: 869 • 2013 ACR/ARHP Annual Meeting

    Anti-Carbamylated Protein Antibodies Are Present Prior To The Diagnosis Of Rheumatoid Arthritis and Predict Future Disease Onset

    Ryan W. Gan1, Leendert A. Trouw2, Jing Shi2, René E.M. Toes2, Tom W. J. Huizinga2, Gary O. Zerbe3, Kevin D. Deane4, Jess Edison5, William R. Gilliland6, Jill M. Norris1 and V. Michael Holers7, 1Epidemiology, Colorado School of Public Health, Aurora, CO, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, 4Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 5Department of Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, 6Walter Reed National Military Medical Center, Bethesda, MD, 7Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Anti-cyclic citrullinated peptide-2 (CCP2) can be present in serum years before a diagnosis of rheumatoid arthritis (RA), and is highly specific (>95%) for the…
  • Abstract Number: 1771 • 2012 ACR/ARHP Annual Meeting

    Anti Carbamylated Protein Antibodies (Anti-CarP) Are Present in Arthralgia Patients and Predict the Development of Rheumatoid Arthritis

    Jing Shi1, Lotte van de Stadt2, Nivine Levarht3, T.W.J. Huizinga4, R. E. M. Toes4, Leendert A. Trouw5 and Dirkjan van Schaardenburg2, 1Rheumatology, LUMC, Leiden, Netherlands, 2Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 3Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Rheumatology, Leiden University Medical Centre, Leiden, Netherlands

    Background/Purpose: Recently, we discovered a new autoantibody system in rheumatoid arthritis (RA): anti carbamylated protein antibodies (anti-CarP).  These antibodies have additional prognostic value in predicting…
  • Abstract Number: 1194 • 2012 ACR/ARHP Annual Meeting

    Prevalence of Anti-Peptidylarginine Deiminase Type 4 Antibodies in Rheumatoid Arthritis and Unaffected First-Degree Relatives in Indigenous North American Populations

    Elizabeth D. Ferucci1, Irene Smolik2, Tammy L. Choromanski3, David B. Robinson4, Marianna M. Newkirk5, Marvin J. Fritzler6, Antony Rosen7, Erika Darrah8 and Hani S. El-Gabalawy4, 1Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, 2Arthritis Center, University of Manitoba, Winnipeg, MB, Canada, 3Alaska Native Tribal Health Consortium, Anchorage, AK, 4Arthritis Centre, University of Manitoba, Winnipeg, MB, Canada, 5Medicine, McGill University Health Centr, Montreal, QC, Canada, 6Medicine, University of Calgary, Calgary, AB, Canada, 7Division of Rheumatology, Johns Hopkins University, Baltimore, MD, 8Division of Rheumatology, The Johns Hopkins University, Baltimore, MD

    Background/Purpose: Antibodies directed against peptidylarginine deiminase type 4 (PAD-4) are present in a subset of patients with rheumatoid arthritis (RA) and are associated with more…
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